The effect of adding an organic solvent to povidone aqueous solution on the size of MCC granules obtained by wet granulation

V. Markeev, S. Tishkov, E. V. Blynskaya, K. S. Kochetov, M. S. Vykhristyuk, А. Maksat
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Abstract

Most of the developed new pharmaceutical substances are insoluble in water, which makes it difficult to create solid dosage forms. This makes researchers use solubilization approaches for poorly soluble molecules. In our study, the applicability of ethyl alcohol as a cosolvent in the technology of wet granulation of tablets was analyzed.
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在聚维酮水溶液中加入有机溶剂对湿法造粒制备的MCC颗粒粒径的影响
大多数已开发的新药不溶于水,这使得难以制造固体剂型。这使得研究人员对难溶分子使用增溶方法。本研究分析了乙醇作为助溶剂在片剂湿制粒工艺中的适用性。
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