HV-CMOS single-chip electronics platform for lab-on-chip DNA analysis

David L. Sloan, Benjamin Martin, Gordon Hall, Andrew Hakman, P. Marshall, S. Martel, C. Backhouse, V. Gaudet, D. Elliott
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引用次数: 1

Abstract

We present a custom integrated circuit (IC) for use in miniaturized genetic test devices with optical coupling with either an optical relay lens or direct surface contact micro-fluidic channels. This IC is capable of high-voltage generation in the 70-300 V range at 10 μA. High-voltage switching circuits for mm-scale capillaries channels with up to 4 electrodes are present. Optical detection with an optical power resolution of 0.46 pW across the diode surface is available for sample detection through a 13-bit analog-to-digital converter. All systems and supporting devices communicate and are powered by a USB connection and fall within the USB 2.0 power budget of 2.5 W.
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用于芯片上DNA分析的HV-CMOS单芯片电子平台
我们提出了一种定制集成电路(IC),用于带有光学继电器透镜或直接表面接触微流体通道的光学耦合的小型化基因测试设备。该IC能够在10 μA电压下产生70-300 V的高压。毫米级毛细管通道的高压开关电路最多可达4个电极。通过13位模数转换器,二极管表面的光功率分辨率为0.46 pW,可用于样品检测。所有系统和支持设备都通过USB连接进行通信和供电,并且在USB 2.0功率预算2.5 W内。
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