Safety assessment of residual amounts of disinfectants based on quaternary ammonium compounds on medical devices

A. L. Karaev, M. V. Bidevkina, M. V. Matrosenko
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Abstract

Has been made an assessment of the toxicity of residual amounts of disinfectants after using them on products, made from various materials, with DS solutions based on QAC. The working solutions were used in concentrations from 0.3 to 7 % (by DV). The safety of the studied samples was assessed by the toxicity index "It" (in%) on an AT-05 Image Analyzer. Washing out of the residual amounts of DS in concentrations of 0.3–0.7 % (by DW) did not significantly affect the total time of disinfection treatment or pre-sterilization cleaning. At higher concentrations of solutions, there were differences in the time of washing test items and dishes for receiving safe amounts of DS. It is concluded that it is inexpedient to use solutions based on QAC in a concentration of more than 4.5 % (in terms of DV) for disinfection treatment and pre-sterilization cleaning of products made of natural and silicone rubber. Keywords: disinfectants, quaternary ammonium compounds, product washing, AT-05 image analyzer, to­xicity index.
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基于季铵化合物的医疗器械消毒剂残留量的安全性评价
采用基于质量质量体系的DS溶液,对不同材质产品使用后消毒剂残留量的毒性进行了评估。工作液的浓度为0.3 ~ 7%(以DV计)。在AT-05图像分析仪上用毒性指数“It”(%)评价所研究样品的安全性。洗涤出浓度为0.3 - 0.7%(以DW计)的DS残留量对消毒处理或灭菌前清洗的总时间没有显著影响。在较高浓度的溶液中,洗涤测试项目和盘子的时间存在差异,以获得安全量的DS。结论:对于天然橡胶和硅橡胶制品,不宜采用浓度大于4.5% (DV)的QAC溶液进行消毒处理和灭菌前清洗。关键词:消毒剂,季铵类化合物,产品洗涤,AT-05图像分析仪,毒性指数
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