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Review of current epidemiological risks of introducing infectious diseases into the Russian Federation from the African continent 审查目前将传染病从非洲大陆引入俄罗斯联邦的流行病学风险
Pub Date : 2023-12-01 DOI: 10.35411/2076-457x-2023-4-33-45
Aleksandra V. Ivanova, A. A. Zubova, Zhanetta A. Kas’jan, L. N. Dmitrieva, E. A. Chumachkova, A. A. Zimirova, Svetlana A. Shcherbakova, Vladimir V. Kutyrev
The paper presents generalized epidemiological data and analyzes the situation in the countries of the African region on infectious diseases requiring measures for sanitary protection of the territory of the Russian Federation. The epidemiological analysis was carried out on the basis of data from the official website of the African Bureau of the World Health Organization (WHO), the African Center for Disease Prevention and Control (CDC), Ministries of Health of the relevant countries, other international organizations, as well as materials of publications in the public domain. The paper summarizes and systematizes data on the incidence and territorial spread of diseases in the region from the perspective of possible risks for those visiting it. The presented data on infectious diseases make it possible to navigate issues related to the risk of infection with infectious diseases, to determine the factors and seasonality of the increased risk of infection, to predict the possibility of importing diseases to the Russian Federation. Keywords: infectious diseases, WHO African region, ensuring sanitary and epidemiological well-being, risk of drift, sanitary protection of the territory, plague, cholera, malaria, EVD, MVD.
本文介绍了流行病学的一般数据,并分析了非洲地区国家需要采取措施保护俄罗斯联邦领土卫生的传染病情况。流行病学分析是在世界卫生组织(WHO)非洲局官方网站、非洲疾病预防与控制中心(CDC)、相关国家卫生部、其他国际组织的数据以及公共领域出版物资料的基础上进行的。本文件从到访者可能面临的风险角度出发,对该地区疾病的发病率和地域传播数据进行了总结和系统化。通过所提供的传染病数据,可以了解与传染病感染风险有关的问题,确定感染风险增加的因素和季节性,预测向俄罗斯联邦输入疾病的可能性。关键词:传染病、世界卫生组织非洲地区、确保卫生和流行病健康、漂移风险、领土卫生保护、鼠疫、霍乱、疟疾、EVD、MVD。
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引用次数: 0
Effect of rheological properties on the antimicrobial activity of isopropyl alcohol 流变特性对异丙醇抗菌活性的影响
Pub Date : 2023-12-01 DOI: 10.35411/2076-457x-2023-4-5-9
Vyacheslav A. Novikov, F. A. Mukabenov, Liudmila G. Panteleeva, Natalia I. Eremeeva, Liudmila I. Istomina, Sergey V. Andreev
Gels are one of the most comprehensive forms of hand hygiene antiseptics. Alcohol-based gels are used in many hospitals around the world for hand antisepsis. The main reason for using antiseptics in gel form is the reduction of skin irritation and dryness and the ease of use (no spillage as quickly as liquid antiseptics when tilting or tipping the bottle). However, gels take longer to dry than other forms, depending on the consistency of the gel. The change in consistency (rheology) has a significant effect on the rate of alcohol evaporation and therefore determines the contact time of the active ingredient with the skin. Since it is believed that the main contribution to antimicrobial activity is made by the active ingredient, and the other components are considered inert, in this work we tested model skin antiseptics based on isopropyl alcohol with different viscosity to evaluate the effectiveness of antiseptics in hand hygiene treatment was carried out in vivo on volunteers. The results obtained do not allow us to unambiguously interpret the effect of viscosity on antimicrobial activity, since up to a gel-former concentration of 1.5?% we observed a decrease in efficacy, and at a concentration of 2?% we observed a concentration higher than that for the aqueous solution of isopropyl alcohol. It follows from our findings that the issue of the influence of viscosity on the antimicrobial activity of skin antiseptics should be studied during disinfectological examination. Keywords: skin antiseptics, gels, rheological properties, hospital-acquired infection.
凝胶是最全面的手部卫生消毒剂之一。世界各地的许多医院都使用酒精凝胶进行手部消毒。使用凝胶状消毒剂的主要原因是可以减少对皮肤的刺激和干燥,而且使用方便(倾斜或倾倒瓶子时不会像液体消毒剂那样很快溢出)。不过,凝胶的干燥时间要比其他形式的凝胶长,这取决于凝胶的稠度。稠度(流变性)的变化对酒精的蒸发速度有很大影响,因此决定了活性成分与皮肤的接触时间。在这项工作中,我们测试了基于不同粘度异丙醇的皮肤抗菌剂模型,以评估抗菌剂在志愿者手部卫生治疗中的有效性。所得结果无法让我们明确解释粘度对抗菌活性的影响,因为在凝胶形成剂浓度为 1.5 % 时,我们观察到药效有所下降,而在浓度为 2 % 时,我们观察到药效高于异丙醇水溶液的浓度。根据我们的研究结果,在消毒检查过程中应研究粘度对皮肤消毒剂抗菌活性的影响问题。关键词:皮肤消毒剂、凝胶、流变特性、医院感染。
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引用次数: 0
The comparative studying food bait for multi-resistant german cockroaches 多抗德国小蠊食物诱饵的比较研究
Pub Date : 2023-12-01 DOI: 10.35411/2076-457x-2023-4-20-26
O. Eremina, V. V. Olifer
The effectiveness of six food baits containing hydramethylnon, imidacloprid, dinotefuran, acetamiprid against the German cockroach of four laboratory cultures – insecticide-susceptible S-NIID and multi-resistant MAG, CR and DM, was evaluated. A slowdown in the manifestation of symptoms of poisoning in cockroaches of resistant cultures was revealed in comparison with susceptible ones. LT95 resistance indices for bait based on hydramethylnon were 0.7–1.1?, dinotefuran – 10-?>?21?, imidacloprid – 1.2–1.6?, acetamiprid – 1.5–2.4?. By day 21, in some variants of experiments, 5?% of males of resistant cultures and 5–45?% of females survived. Keywords: German cockroach, resistance, food baits, resistance index.
评估了六种含有水胺酮、吡虫啉、乐果、啶虫脒的食物毒饵对四种实验室培养的德国小蠊--对杀虫剂敏感的 S-NIID 和多重抗药性的 MAG、CR 和 DM--的效果。结果表明,与易感蟑螂相比,抗药性蟑螂的中毒症状有所减缓。基于水胺硫磷的诱饵的 LT95 抗性指数为 0.7-1.1?,二硝基呋喃 - 10->?21?,吡虫啉 - 1.2-1.6?,啶虫脒 - 1.5-2.4?。到第21天时,在某些实验变体中,抗性培养物中有5%的雄虫和5-45%的雌虫存活。关键词:德国小蠊德国小蠊 抗性 食物毒饵 抗性指数
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引用次数: 0
Comparative assessment of the toxicity and virucidal properties of disinfectants used when working with the SARS-CoV-2 virus in isolated virology laboratories 对隔离病毒学实验室处理 SARS-CoV-2 病毒时所用消毒剂的毒性和杀毒性能进行比较评估
Pub Date : 2023-12-01 DOI: 10.35411/2076-457x-2023-4-10-20
V. V. Zolin, Oksana P. Os’kina, Vladislav V. Solodky, T. Gosteva, M. N. Eremina
The choice of disinfectants and their combinations for the final disinfection of the premises of «infectious» areas of laboratories of biosafety level 3–4, in which work is carried out with viruses with epidemic potential, is important for reducing the toxic effect of these disinfectants on personnel while maintaining 100?% disinfection efficiency. Purpose of the study: to study the toxicity of disinfectants of different groups for cell culture, to select a toxicity neutralizer, to study the virucidal activity of these disinfectants and their combinations against the SARS-CoV-2 virus. Materials and methods: experimental studies were carried out using the reference strain of coronavirus SARS-CoV-2, namely the hCoV-19/Australia/VIC01/2020 (AUS) strain (Wuhan variant), obtained from the State Collection of Causative Agents of Viral Infectious Diseases and Rickettsial Diseases, functioning on the basis of the Federal Budgetary Institution State Scientific Center for Virology and Biotechnology «Vector» of Rospotrebnadzor. The residual infectious activity of the virus was determined by titrating samples in cell culture. To conduct the research, we used a Vero E6 cell culture obtained from the Collection of Cell Cultures of the Federal Budgetary Institution of Scientific Research Center for Virology and Biochemistry «Vector» of Rospotrebnadzor in the form of a 2-day monolayer with a confluency of 95–100?%. Results. As a result of the studies, experimental data were obtained on the dynamics of the virucidal activity of different groups of disinfectants and their combinations against the SARS-CoV-2 virus. The degree of toxicity of disinfectants for Vero E6 cell culture is shown. Optimal combinations of disinfectants and a 40?% aqueous solution of formaldehyde (hereinafter referred to as formalin) have been selected, increasing its disinfection efficiency at an initial concentration halved, which can be used for final disinfection treatment of the premises of isolated virology laboratories conducting work with the SARS-CoV- coronavirus. Conclusion. The results obtained indicate that when using selected combinations of disinfectants to carry out final disinfection with formaldehyde vapors formed during the evaporation of formaldehyde as a result of its heating, a twofold decrease in the initial concentration of formalin is possible, leading to a decrease in its toxic effect on personnel, while maintaining 100?% efficiency disinfection. Keywords: disinfection, disinfectants, formaldehyde, SARS-CoV-2 coronavirus, disinfection efficiency, cytotoxicity.
生物安全等级 3-4 级实验室的 "传染 "区内有可能感染流行性病毒,选择何种消毒剂及 其组合物对这些实验室进行最终消毒,对于减少这些消毒剂对人员的毒性影响,同时保 持 100%的消毒效率非常重要。研究目的:研究不同组别的消毒剂对细胞培养的毒性,选择一种毒性中和剂,研究这些消毒剂及其组合对 SARS-CoV-2 病毒的杀毒活性。材料和方法:实验研究使用了冠状病毒 SARS-CoV-2 的参考毒株,即 hCoV-19/Australia/VIC01/2020 (AUS) 株(武汉变种),该毒株来自病毒性传染病和立克次体病病原体国家保藏中心,该中心是在 Rospotrebnadzor 的联邦预算机构国家病毒学和生物技术科学中心 "向量 "的基础上运作的。通过在细胞培养中滴定样本,确定了病毒的剩余感染活性。为了进行研究,我们使用了从罗斯波特列布纳佐尔病毒学和生物化学 "矢量 "科学研究中心联邦预算机构细胞培养物收集处获得的 Vero E6 细胞培养物,该培养物为 2 天单层,汇合度为 95-100%。结果。通过研究,获得了不同类别消毒剂及其组合对 SARS-CoV-2 病毒杀毒活性动态的实验数据。显示了消毒剂对 Vero E6 细胞培养的毒性程度。筛选出了消毒剂和 40%甲醛水溶液(以下简称福尔马林)的最佳组合,在初始浓度减半的情况下提高了消毒效率,可用于进行 SARS-CoV- 冠状病毒工作的隔离病毒学实验室场所的最终消毒处理。结论研究结果表明,使用选定的消毒剂组合对甲醛加热蒸发过程中形成的甲醛蒸汽进行最终消毒时,可将福尔马林的初始浓度降低两倍,从而降低其对人员的毒性影响,同时保持 100%的消毒效率。关键词:消毒、消毒剂、甲醛、SARS-CoV-2 冠状病毒、消毒效率、细胞毒性。
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引用次数: 0
Strategy for the development of training in the field of medical and preventive affairs in St. Petersburg at the current stage 圣彼得堡现阶段医疗和预防领域培训发展战略
Pub Date : 2023-12-01 DOI: 10.35411/2076-457x-2023-4-56-59
Natalya Anatolyevna Vatolina, Natalia Vitalievna Fedotova, Yuriy Mikhaylovich Shishkin, L. V. Lyalina, T. V. Osmirko
The development of the training system in the field of medical and preventive affairs in St. Petersburg was analyzed. The main tasks of staffing organizations and health care institutions, including the disinfection profile, are noted, which require immediate solution Keywords: licensing of disinfection activities, sanitary and epidemiological service, organizations and institutions of disinfection profile, medical organizations, secondary vocational education in the specialty «medical and preventive business».
分析了圣彼得堡医疗和预防事务领域培训体系的发展情况。关键词:消毒活动许可、卫生和流行病学服务、消毒组织和机构、医疗组织、"医疗和预防事务 "专业的中等职业教育。
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引用次数: 0
Use of entomopathogenic fungi against bed bugs 利用昆虫病原真菌防治臭虫
Pub Date : 2023-12-01 DOI: 10.35411/2076-457x-2023-4-27-33
K. Krivonos, O. Eremina, V. V. Olifer
A literature review on the effectiveness of the use of entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana for the destruction of bed bugs is given. Bed bug resistance to pyrethroids does not result in cross-resistance to infection with B. bassiana spores. Insect mortality is highly dependent on the concentration of fungal conidia, which is critical to induce horizontal transfer capable of increasing insect population mortality without the need for direct contact between bed bugs and the inoculated substrate. Pyrethroid residues on treated surfaces significantly reduce the germination of B. bassiana spores. At present, resistance of insects to mycoinsecticides in the field has not been revealed, however, it has been shown that in laboratory conditions its occurrence is possible. Keywords: entomopathogenic fungi, Metarhizium, Beauveria, biopesticides, bed bug, resistance.
文献综述了使用昆虫病原真菌 Metarhizium anisopliae 和 Beauveria bassiana 消灭臭虫的效果。臭虫对拟除虫菊酯的抗药性不会导致对 B. bassiana 孢子感染的交叉抗药性。昆虫死亡率在很大程度上取决于真菌分生孢子的浓度,这是诱导水平转移的关键,能够增加昆虫种群死亡率,而无需臭虫与接种基质直接接触。处理过的表面上的除虫菊酯残留物会大大降低 B. bassiana 孢子的发芽率。目前,还没有发现昆虫在田间对杀螨剂产生抗药性的情况,但已经证明在实验室条件下可能会出现这种情况。关键词:昆虫病原真菌、Metarhizium、Beauveria、生物杀虫剂、臭虫、抗药性。
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引用次数: 0
On the possibility of using cationic surfactants to impart antimicrobial properties to textile materials 利用阳离子表面活性剂赋予纺织材料抗菌性能的可能性
Pub Date : 2023-06-01 DOI: 10.35411/2076-457x-2023-2-22-29
Anastasia S. Zvereva, Sergey V. Andreev, A. Serov, S. Zverev, Vyacheslav A. Novikov, Alexandra D. Kritskaya, V. Vinokurov, K. A. Sakharov
The COVID-19 pandemic has demonstrated the need for improved measures to prevent infectious diseases. Combating pathogens once they have been released into the environment is complicated by their widespread distribution. It is necessary to prevent the contamination of environmental objects. One possible way to do this is to create materials that have antimicrobial action without exposure to disinfectants and thus begin to have an antimicrobial effect on microorganisms immediately upon contact. Textile materials are widely used in medical organizations and are one of the factors of pathogenic microflora spreading. In this work, the possibility of using substances from the group of cationic surfactants to impart antimicrobial properties to textile materials was considered. Substances from different classes were used – tertiary amines, quaternary ammonium compounds, polymeric guanidine derivatives. The substances were applied from aqueous solutions using a laboratory analogue of a drying and a shirring machine. An acrylate binder with thermal initiation of polymerization was used to fix the active substances to the tissues. The content of the active substances in the tissues after application was determined by high-performance liquid chromatography. Antimicrobial activity of the obtained materials was checked by the agar plate method and the area of the growth retardation zone was estimated. Tissues containing N,N-bis(3-aminopropyl)dodecylamine showed the highest activity, tissues with poly (2-hydroxypropyl dimethylammonium) chloride the lowest. Keywords: antimicrobial materials, antimicrobial textile, HAI, cationic surfactants.
COVID-19大流行表明,有必要改进预防传染病的措施。一旦病原体被释放到环境中,由于它们的广泛分布,与它们作斗争变得复杂。要防止对环境物体的污染。一种可能的方法是制造出无需接触消毒剂就具有抗菌作用的材料,从而在接触微生物后立即开始对微生物产生抗菌作用。纺织材料广泛应用于医疗机构,是病原菌群传播的因素之一。在这项工作中,考虑了使用阳离子表面活性剂基团中的物质赋予纺织材料抗菌性能的可能性。使用了不同类别的物质-叔胺,季铵化合物,聚合胍衍生物。这些物质是用实验室模拟的干燥和起皱机从水溶液中施用的。采用热引发聚合的丙烯酸酯粘合剂将活性物质固定在组织上。采用高效液相色谱法测定涂敷后组织中活性物质的含量。用琼脂平板法测定所得材料的抑菌活性,并估计生长迟缓区面积。含N,N-二(3-氨基丙基)十二烷基胺的组织活性最高,含聚(2-羟丙基二甲基氯化铵)的组织活性最低。关键词:抗菌材料,抗菌纺织品,HAI,阳离子表面活性剂
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引用次数: 0
What remains behind the scenes when choosing a skin antiseptic 在选择皮肤杀菌剂时,幕后还有什么
Pub Date : 2023-06-01 DOI: 10.35411/2076-457x-2023-2-30-36
A. Lokotkova, El’dar Khamzyaevich Mamkeev, O. A. Nazarova, Naziko Elgudzhaevna Koguashvili
Disinfection of the hands of medical personnel at the present stage is one of the leading measures in the prevention of infections associated with the provision of medical care (HCAI). Regulatory documents regulate the use of alcohol antiseptics. When choosing skin antiseptics, it is necessary to arm yourself with a number of criteria to minimize the risk of transmission of HCAI by contact and household contact, as well as to avoid negative effects on the skin of the hands of medical personnel. The paper presents an analysis and selection of criteria when choosing a skin antiseptic for hygienic hand treatment, based on regulatory documents and the results of randomized trials. The main selection criteria are identified: the type of alcohol and its concentration (by weight) depending on the type of pathogen, the amount of antiseptic for one treatment, the duration of exposure and the presence of additional components and substances. Keywords: hand hygiene, alcohol-based handrubs (ABHR), persistent activity, Ethanol, 1-propanol and 2-propanol, non-enveloped viruses.
在目前阶段,对医务人员的手进行消毒是预防与提供医疗服务有关的感染的主要措施之一。规范性文件规定了酒精防腐剂的使用。在选择皮肤防腐剂时,有必要掌握一些标准,以尽量减少通过接触和家庭接触传播HCAI的风险,并避免对医务人员的手部皮肤产生负面影响。本文根据监管文件和随机试验的结果,分析和选择用于手部卫生治疗的皮肤杀菌剂的标准。确定了主要的选择标准:酒精的类型及其浓度(按重量计算)取决于病原体的类型、一次处理的防腐剂用量、接触的持续时间以及是否存在额外的成分和物质。关键词:手卫生,醇基洗手液,持续活性,乙醇,1-丙醇和2-丙醇,非包膜病毒。
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引用次数: 0
On the cyclical manifestations of the dynamics of the incidence of hemorrhagic fever with renal syndrome in the Russian Federation 关于俄罗斯联邦肾综合征出血热发病率动态的周期性表现
Pub Date : 2023-06-01 DOI: 10.35411/2076-457x-2023-2-57-66
P. Mochalkin, Mochalkin, L. A. Farvazova, N. V. Popov, Mikhail Yurevich Devyatkov
The hypothesis about a 49-year cycle in the incidence of HFRS in the Russian Federation in the period of 1957–2021 is substantiated. It has been established that the identified 49-year HFRS incidence cycle consists of 2 phases: a low incidence phase lasting 20 years (1967–1986) and a high incidence phase lasting approximately 29 years (1987–2016). It is of note that since 2017, there has been another phase of low incidence of HFRS in the Russian Federation, which, presumably, will continue until 2036. The prognostic indicator of the HFRS incidence for 2022 in the Russian Federation, obtained taking into account the current phase of low incidence, was 5.35?±?1.34 per 100 thousand population, with an actual level of 4.73 per 100 thousand population. A high degree of similarity in the dynamics of the HFRS incidence has been identified for the territory of the Republic of Bashkortostan (r = 0.87), the Republic of Tatarstan (r = 0.88) and the Russian Federation. It is outlined that the identified 20- and 29-year phases of the 49-year HFRS incidence cycle in the Russian Federation are generally determined by the epidemic activity of natural foci of the Puumala virus and coincide in duration with climate change waves in the European part of the Russian Federation. Keywords: сyclical nature of HFRS incidence, enzootic as regards HFRS territory, the Republic of Bashkortostan, epidemiological forecast, climate change.
关于1957-2021年期间俄罗斯联邦HFRS发病周期为49年的假设得到证实。已确定的49年HFRS发病周期包括2个阶段:持续20年(1967-1986)的低发病阶段和持续约29年(1987-2016)的高发病阶段。值得注意的是,自2017年以来,俄罗斯联邦出现了另一个HFRS低发病率阶段,这一阶段可能会持续到2036年。考虑到当前低发病率阶段,俄罗斯联邦2022年HFRS发病率预测指标为5.35±1.34 / 10万人口,实际水平为4.73 / 10万人口。已查明巴什科尔托斯坦共和国(r = 0.87)、鞑靼斯坦共和国(r = 0.88)和俄罗斯联邦境内的HFRS发病动态高度相似。报告概述说,在俄罗斯联邦49年的HFRS发病周期中,确定的20年和29年阶段通常由普马拉病毒自然疫源地的流行活动决定,并且在持续时间上与俄罗斯联邦欧洲部分的气候变化波相吻合。关键词:HFRS发病的周期性;HFRS发病地区地方性流行病学;巴什科尔托斯坦共和国;
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引用次数: 0
Characteristics of endemicity by tick-borne infections (tick-borne encephalitis, ixodic tick-borne borrelioses) in the Ulyanovsk region 乌里扬诺夫斯克地区蜱传感染(蜱传脑炎、蜱传疏螺旋体)的地方性特征
Pub Date : 2023-06-01 DOI: 10.35411/2076-457x-2023-2-54-57
A. A. Nafeev, P. G. Vovkotech
The work presents the results of monitoring the incidence of the population and the lesion of ticks with the tick-borne encephalitis virus, borrelias of ixodic tick-borne borrelioses for 2002–2021. in the administrative territories of the Ulyanovsk region endemic to tick-borne encephalitis. The results of monitoring the number of Ixodes and Dermacentor mites, their species composition and their changes are presented. Keywords: monitoring, ticks, tick-borne encephalitis, ixodic tick-borne borreliosis, endemicity, Ulyanovsk region.
这项工作介绍了2002-2021年监测蜱传脑炎病毒、蜱传疏螺旋体的种群发病率和蜱病损害的结果。在乌里扬诺夫斯克州的行政区域内流行蜱传脑炎。介绍了本地区蜱螨和革螨的数量、种类组成及变化情况。关键词:监测,蜱,蜱传脑炎,蜱传疏螺旋体病,地方性,乌里扬诺夫斯克地区
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引用次数: 0
期刊
Disinfection affairs
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