Furkan Gökçe, Paolo S. Ravaynia, A. Kaestli, M. Modena, A. Hierlemann, K. Renggli
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引用次数: 0
Abstract
Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) unit that enables to monitor the flowing cancer cells in real-time. The electric parameters, such as membrane conductivity and dielectric properties, alter upon the death of leukemia cells. Thus, drug-cancer interactions can be studied online and label-free by means of EIS. In this study, we present proof-of-concept experimental results that show the potential of EIS for real-time drug efficacy research.
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