Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study -

International Journal of Medical Science and Public Health Pub Date : 2017-01-01 DOI:10.5455/IJMSPH.2016.07062016541

K. Datkhile, M. Patil, Tejasvi S. Khamkar, Rohit D. Vhaval, P. Durgawale, P. G. Chougule, Anand K. Gudur, S. Kakade

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引用次数: 3

Abstract

Background: Smoking and alcohol related head and neck cancer is a major concern of health risk in urban and rural areas of India. Objective: This study was aimed to determine the frequency of polymorphisms in DNA repair genes, hOGG1 at codon (cd) 326 and APE1 at cd 148 in patients of oral cancer from Maharashtra and to evaluate their association with oral cancer development. Materials and Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze gene polymorphisms in 200 patients with oral cancer and 200 age and sex matched disease-free controls were used. Result: The results obtained from the present study indicated that there was no significant difference in the genotype distribution between oral cancer patients and controls for APE1 (p>0.05). The result showed that allele frequencies of hOGG1Cys326 (OR= 8.73; 95% CI= (2.51-30.39); p=

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印度农村人口中DNA修复基因(hOGG1和APE1)的遗传多态性及其与口腔癌易感性的关系:一项基于医院的病例对照研究

背景:吸烟和酒精相关的头颈癌是印度城市和农村地区健康风险的一个主要问题。目的:本研究旨在测定马哈拉施特拉邦口腔癌患者DNA修复基因hOGG1密码子(cd) 326位点和APE1密码子(cd) 148位点多态性的频率，并评估其与口腔癌发展的关系。材料与方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对200例口腔癌患者和200例年龄、性别匹配的无病对照进行基因多态性分析。结果:本研究结果显示，口腔癌患者与对照组APE1基因型分布无显著差异(p>0.05)。结果表明，hOGG1Cys326的等位基因频率(OR= 8.73;95% ci = (2.51-30.39);p =

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International Journal of Medical Science and Public Health

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