Pub Date : 2021-01-01DOI: 10.5455/IJMSPH.2020.08228202018012021
Shweta Gupta, S. Tiwari, V. Verma, W. Ali, Shraddha Singh
Background: Hearing impairment is the frequent sensory deficit which affects newborns, children, adults, and the elderly. Objective: This study was conducted to find out the correlation of homocysteine (Hcy) and Vitamin B12 level in children aged 212 years having sensorineural hearing loss (SNHL). Materials and Methods: Seventy subjects were taken in this cross-sectional study after taking approval from the Institutional Ethics Committee of KGMU, UP. (No.2096/ Ethics/R. Cell-17Dated-20/11/2017). Half (n = 35) had moderate-to-severe hearing loss, while remaining 35 had severe to profound hearing loss. The biochemical assessment of serum Hcy and Vitamin B12 level was done by chemiluminescent microparticle immunoassay method. The statistical analysis was done using Statistical Package for the Social Sciences (SPSS) Version 21.0 statistical Analysis Software. The values were represented in Number(%) and Mean±SD. Results: The mean Vitamin B12 level was significantly higher in children with moderate-to-severe hearing loss (241.06±75.25 pg/ml) as compared to those having severe to profound hearing loss (203.03±80.53 pg/ml) (P = 0.045). However, mean Hcy level was significantly higher in severe to profound hearing loss group (13.49±4.60 μmol/ml) in comparison to moderate-to-severe hearing loss group (11.14±4.57 μmol/ml) (P = 0.035). On evaluating the correlation between Vitamin B12 level and Hcy level, a strong inverse significant correlation was observed for overall cases (r=−0.691; P < 0.001) and strongly significant for moderate-to-severe hearing loss group (r=−0.779; P < 0.001). The correlation was moderate significant for severe to profound hearing loss group (r=−0.572; P < 0.001). Conclusion: This study concluded that increase Hcy level is inversely associated with decrease Vitamin B12 level in SNHL. This increase Hcy level may be used as a predictor for early detection of SNHL in children so that early therapeutic interventions can be started to improve the hearing in children.
{"title":"Correlation of homocysteine and Vitamin B12 level as a surrogative marker for early detection of sensorineural hearing loss in children","authors":"Shweta Gupta, S. Tiwari, V. Verma, W. Ali, Shraddha Singh","doi":"10.5455/IJMSPH.2020.08228202018012021","DOIUrl":"https://doi.org/10.5455/IJMSPH.2020.08228202018012021","url":null,"abstract":"Background: Hearing impairment is the frequent sensory deficit which affects newborns, children, adults, and the elderly. Objective: This study was conducted to find out the correlation of homocysteine (Hcy) and Vitamin B12 level in children aged 212 years having sensorineural hearing loss (SNHL). Materials and Methods: Seventy subjects were taken in this cross-sectional study after taking approval from the Institutional Ethics Committee of KGMU, UP. (No.2096/ Ethics/R. Cell-17Dated-20/11/2017). Half (n = 35) had moderate-to-severe hearing loss, while remaining 35 had severe to profound hearing loss. The biochemical assessment of serum Hcy and Vitamin B12 level was done by chemiluminescent microparticle immunoassay method. The statistical analysis was done using Statistical Package for the Social Sciences (SPSS) Version 21.0 statistical Analysis Software. The values were represented in Number(%) and Mean±SD. Results: The mean Vitamin B12 level was significantly higher in children with moderate-to-severe hearing loss (241.06±75.25 pg/ml) as compared to those having severe to profound hearing loss (203.03±80.53 pg/ml) (P = 0.045). However, mean Hcy level was significantly higher in severe to profound hearing loss group (13.49±4.60 μmol/ml) in comparison to moderate-to-severe hearing loss group (11.14±4.57 μmol/ml) (P = 0.035). On evaluating the correlation between Vitamin B12 level and Hcy level, a strong inverse significant correlation was observed for overall cases (r=−0.691; P < 0.001) and strongly significant for moderate-to-severe hearing loss group (r=−0.779; P < 0.001). The correlation was moderate significant for severe to profound hearing loss group (r=−0.572; P < 0.001). Conclusion: This study concluded that increase Hcy level is inversely associated with decrease Vitamin B12 level in SNHL. This increase Hcy level may be used as a predictor for early detection of SNHL in children so that early therapeutic interventions can be started to improve the hearing in children.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"54 1","pages":"612-615"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74876315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/ijmsph.2021.08095202109122021
S. Tengrang
Background: Coronavirus disease 2019 (COVID-19) is an epidemic that has greatly affected the daily life of people around the world. This epidemic, in addition to affecting lives, also affects other matters such as the economy or government administration that need to find ways to reduce the epidemic rate. That is to provide adequate quality vaccines for the people of the country. Finally, the government finds measures to stop the spread of COVID-19. Objectives: This study aimed to assess an acceptance to be vaccinated against COVID-19. Materials and Methods: Intention to be vaccinated against COVID-19 was measured with a question A"When a vaccine for COVID-19 is ready for you, will you get vaccinated?A" Response options were A"yes, A" A"not sureA" and A"no.A" Participants who responded A"not sureA" or A"noA" were asked to provide a reason. Results: A total of 400 responses were received. Overall, 38.5% (n = 154) of participants intended to get vaccinated, 29.5% (n = 117) were unsure, and 32.25% (n = 129) were not planning to get vaccinated. Factors that are independently related to vaccine hesitancy (A"not sureA" or A"yesA" response) include being male, risk perception of getting COVID-19, confidence in the government in handling the pandemic. Conclusion: A total of 400 participants, in the study, 38.5% (n = 154) of participants intended to get vaccinated, 29.5% (n = 117) were unsure, and 32.25% (n = 129) were not planning to get vaccinated. Male participants had a higher chance to refuse to vaccinate more than female 2.69 times. Predictive factors for COVID-19 vaccination were risk perception of contracting COVID-19 and lack of confidence in the government handling the pandemic of COVID-19.
{"title":"Intention to vaccinate against COVID-19 of Thai people in Trang Province, Thailand: A cross-sectional study","authors":"S. Tengrang","doi":"10.5455/ijmsph.2021.08095202109122021","DOIUrl":"https://doi.org/10.5455/ijmsph.2021.08095202109122021","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) is an epidemic that has greatly affected the daily life of people around the world. This epidemic, in addition to affecting lives, also affects other matters such as the economy or government administration that need to find ways to reduce the epidemic rate. That is to provide adequate quality vaccines for the people of the country. Finally, the government finds measures to stop the spread of COVID-19. Objectives: This study aimed to assess an acceptance to be vaccinated against COVID-19. Materials and Methods: Intention to be vaccinated against COVID-19 was measured with a question A\"When a vaccine for COVID-19 is ready for you, will you get vaccinated?A\" Response options were A\"yes, A\" A\"not sureA\" and A\"no.A\" Participants who responded A\"not sureA\" or A\"noA\" were asked to provide a reason. Results: A total of 400 responses were received. Overall, 38.5% (n = 154) of participants intended to get vaccinated, 29.5% (n = 117) were unsure, and 32.25% (n = 129) were not planning to get vaccinated. Factors that are independently related to vaccine hesitancy (A\"not sureA\" or A\"yesA\" response) include being male, risk perception of getting COVID-19, confidence in the government in handling the pandemic. Conclusion: A total of 400 participants, in the study, 38.5% (n = 154) of participants intended to get vaccinated, 29.5% (n = 117) were unsure, and 32.25% (n = 129) were not planning to get vaccinated. Male participants had a higher chance to refuse to vaccinate more than female 2.69 times. Predictive factors for COVID-19 vaccination were risk perception of contracting COVID-19 and lack of confidence in the government handling the pandemic of COVID-19.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78578944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/jmsph.2021.08083202109092021
Pornlaphat Sumkaeo, Kanphitcha Opas
{"title":"Effect of multitasking skills on stress levels in high school students during the outbreak of a coronavirus disease 2019 pandemic","authors":"Pornlaphat Sumkaeo, Kanphitcha Opas","doi":"10.5455/jmsph.2021.08083202109092021","DOIUrl":"https://doi.org/10.5455/jmsph.2021.08083202109092021","url":null,"abstract":"","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85398183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/ijmsph.2021.05037202115072021
N. Khan, Deepti Saini, A. Kochar
Background: Penetrating keratoplasty (PK) is a surgical procedure where a diseased cornea is replaced by donated corneal tissue which has been removed from a recently deceased individual having no known diseases. Objectives: The objectives of the study were to assess the indications and demographic profile of patients undergoing PK. Materials and Methods: In this retrospective cross-sectional non-interventional hospital-based clinical analysis study, hospital records of patients who had undergone for PK surgery at PBM Eye Hospital, S.P. Medical College, Bikaner, Rajasthan, from 1991 to 2020 were reviewed for demographic data (age, sex, age at presentation, etc.), indications for PK, treatment history and comorbid conditions. A total of 387 patients were included in this study. Results: The most common age group for PK was 6170 years (22.23%) followed by 5160 years (21.05%) and 4150 years (15.48%). About 65.96% patients were male, 30.87% patients were female, and 3.17% patients were children (
{"title":"A clinical study on indications and demography for penetrating keratoplasty in northwest Rajasthan","authors":"N. Khan, Deepti Saini, A. Kochar","doi":"10.5455/ijmsph.2021.05037202115072021","DOIUrl":"https://doi.org/10.5455/ijmsph.2021.05037202115072021","url":null,"abstract":"Background: Penetrating keratoplasty (PK) is a surgical procedure where a diseased cornea is replaced by donated corneal tissue which has been removed from a recently deceased individual having no known diseases. Objectives: The objectives of the study were to assess the indications and demographic profile of patients undergoing PK. Materials and Methods: In this retrospective cross-sectional non-interventional hospital-based clinical analysis study, hospital records of patients who had undergone for PK surgery at PBM Eye Hospital, S.P. Medical College, Bikaner, Rajasthan, from 1991 to 2020 were reviewed for demographic data (age, sex, age at presentation, etc.), indications for PK, treatment history and comorbid conditions. A total of 387 patients were included in this study. Results: The most common age group for PK was 6170 years (22.23%) followed by 5160 years (21.05%) and 4150 years (15.48%). About 65.96% patients were male, 30.87% patients were female, and 3.17% patients were children (","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76242706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/ijmsph.2021.08089202105092021
Thitalee Bunchuay
Background: Coronavirus disease 2019 (COVID-19) or Coronavirus disease 2019 has rapidly affected all aspects of life around and become a major threat to public health around the world. One of the most important actions that need to be taken to stop the pandemic is vaccinations. Managing the COVID-19 pandemic in the long term, unwillingness to receive vaccinations, and negative attitudes toward vaccines are major barriers. Objectives: The objective of the study is to assess willing of Thai adolescents to get vaccinated against COVID-19 among high school students in Sacred Heart Convent School of Bangkok. Materials and Methods: The study was conducted using a questionnaire. A total of 80 students participated. Knowledge about COVID-19 and COVID-19 vaccine, Risk Perception of COVID-19 infection, and Confidence in the government in handling the pandemic. Independent t-test and ANOVA were used to analyze differences between outcomes and sociodemographic. Attitudes toward vaccination were analyzed by a generalized linear model. Results: This study showed that the vaccine acceptance rate was 15% and vaccine refusal was 85%. 15% of female participants accepted to be vaccinated against COVID-19 while all-male participants refused to be vaccinated against COVID-19. In the age of 17 participants, 6.25% showed the highest willingness to be vaccinated. Of the students who did not vaccinate Influenza 13.75% accepted to be vaccinated against COVID-19. Of the students who live in urban areas, 51.25% and single house 66.25% refuse to be vaccinated against COVID-19 respectively. Conclusion: This study indicates confidence in the government in handling the pandemic influenced the willingness to vaccinate against COVID-19.
{"title":"Willingness of Thai adolescent to get vaccinated against coronavirus disease 2019: A cross-sectional study in Bangkok, Thailand","authors":"Thitalee Bunchuay","doi":"10.5455/ijmsph.2021.08089202105092021","DOIUrl":"https://doi.org/10.5455/ijmsph.2021.08089202105092021","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) or Coronavirus disease 2019 has rapidly affected all aspects of life around and become a major threat to public health around the world. One of the most important actions that need to be taken to stop the pandemic is vaccinations. Managing the COVID-19 pandemic in the long term, unwillingness to receive vaccinations, and negative attitudes toward vaccines are major barriers. Objectives: The objective of the study is to assess willing of Thai adolescents to get vaccinated against COVID-19 among high school students in Sacred Heart Convent School of Bangkok. Materials and Methods: The study was conducted using a questionnaire. A total of 80 students participated. Knowledge about COVID-19 and COVID-19 vaccine, Risk Perception of COVID-19 infection, and Confidence in the government in handling the pandemic. Independent t-test and ANOVA were used to analyze differences between outcomes and sociodemographic. Attitudes toward vaccination were analyzed by a generalized linear model. Results: This study showed that the vaccine acceptance rate was 15% and vaccine refusal was 85%. 15% of female participants accepted to be vaccinated against COVID-19 while all-male participants refused to be vaccinated against COVID-19. In the age of 17 participants, 6.25% showed the highest willingness to be vaccinated. Of the students who did not vaccinate Influenza 13.75% accepted to be vaccinated against COVID-19. Of the students who live in urban areas, 51.25% and single house 66.25% refuse to be vaccinated against COVID-19 respectively. Conclusion: This study indicates confidence in the government in handling the pandemic influenced the willingness to vaccinate against COVID-19.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88084815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Fathima, Joseph Thomas, A. Johnson, S. Mathew, C. Tomy
{"title":"Knowledge about cardio-vascular disease and its risk factors among college-going students in peri-urban Bengaluru, South India","authors":"F. Fathima, Joseph Thomas, A. Johnson, S. Mathew, C. Tomy","doi":"10.4103/JNCD.JNCD_47_20","DOIUrl":"https://doi.org/10.4103/JNCD.JNCD_47_20","url":null,"abstract":"","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"15 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87377689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/ijmsph.2021.06053202111082021
Arpapatravee Luenarm
Background: Over a year of the spreading of coronavirus disease (COVID-19), there is now the development of COVID- 19 vaccines with various developers. In Thailand, there are two developers;Sinovac and AstraZeneca. Due to the limited supply, the government of Thailand announced the first very first group to be vaccinated is health workers and persons younger than 18 were not recommended to take the vaccine. According to the Thailand situation, knowing the willingness of Grade 12 students is important because they are the next group of people to take the vaccine. The government should consider the factors that make them or make them not take the vaccine for the country to pass through the COVID-19. Objectives: The purpose of this study was to assess knowledge and understanding regarding COVID19, risk perception of getting COVID-19, level of news perception about COVID-19, and the concern with the willingness to vaccinate against COVID-19 among grade 12 students of Chonkanyanukoon school. Materials and Methods: The study was conducted using a questionnaire in April 2021. A total of 246 students participated. Questions related to knowledge and understanding regarding COVID19, risk perception of getting COVID-19, level of news perception about COVID-19, and the concern with a willingness to vaccinate against COVID-19 were assessed. Differences between outcomes and socio-demographics were analyzed through independent t-test and the ANOVA. For the willingness to vaccinate was analyzed by a generalized linear model. This study is quantitative research, which involves developing a survey. The survey is in the format of Google Forms which was developed from March 01 to April 27, 2021, and was sent out to Grade 12 students of Chonkanyanukoon school, Chonburi, Thailand students on April 08. The survey was voluntary and 246 responses were received. Results: Students revealed good knowledge and understanding regarding COVID-19, correctly answering 8.5 scores (standard deviation [S.D.] = 1.64) from 10 questions, moderate level of risk perception at an average score of 17.17 (S.D. = 5.99) out of 25 questions, and a high Level of COVID-19 news perception which the average score of 7.97 (S.D. = 1.48) from ten questions and willingness to vaccinate against COVID-19 with the average score of 3.10 (S.D. = 1.73) out of five questions. The news perceptions of COVID-19 (Beta = 0.314, P = 0.01) and the chance of contracting COVID-19 (Beta= 0.130, P = 0.01). Conclusion: This study provides useful data to identify the probability of the students taking the COVID- 19 vaccine. Consistency is essential to promote good knowledge and attitude in taking the COVID19 vaccine.
{"title":"Willingness to vaccinate against coronavirus disease-19 of high school students","authors":"Arpapatravee Luenarm","doi":"10.5455/ijmsph.2021.06053202111082021","DOIUrl":"https://doi.org/10.5455/ijmsph.2021.06053202111082021","url":null,"abstract":"Background: Over a year of the spreading of coronavirus disease (COVID-19), there is now the development of COVID- 19 vaccines with various developers. In Thailand, there are two developers;Sinovac and AstraZeneca. Due to the limited supply, the government of Thailand announced the first very first group to be vaccinated is health workers and persons younger than 18 were not recommended to take the vaccine. According to the Thailand situation, knowing the willingness of Grade 12 students is important because they are the next group of people to take the vaccine. The government should consider the factors that make them or make them not take the vaccine for the country to pass through the COVID-19. Objectives: The purpose of this study was to assess knowledge and understanding regarding COVID19, risk perception of getting COVID-19, level of news perception about COVID-19, and the concern with the willingness to vaccinate against COVID-19 among grade 12 students of Chonkanyanukoon school. Materials and Methods: The study was conducted using a questionnaire in April 2021. A total of 246 students participated. Questions related to knowledge and understanding regarding COVID19, risk perception of getting COVID-19, level of news perception about COVID-19, and the concern with a willingness to vaccinate against COVID-19 were assessed. Differences between outcomes and socio-demographics were analyzed through independent t-test and the ANOVA. For the willingness to vaccinate was analyzed by a generalized linear model. This study is quantitative research, which involves developing a survey. The survey is in the format of Google Forms which was developed from March 01 to April 27, 2021, and was sent out to Grade 12 students of Chonkanyanukoon school, Chonburi, Thailand students on April 08. The survey was voluntary and 246 responses were received. Results: Students revealed good knowledge and understanding regarding COVID-19, correctly answering 8.5 scores (standard deviation [S.D.] = 1.64) from 10 questions, moderate level of risk perception at an average score of 17.17 (S.D. = 5.99) out of 25 questions, and a high Level of COVID-19 news perception which the average score of 7.97 (S.D. = 1.48) from ten questions and willingness to vaccinate against COVID-19 with the average score of 3.10 (S.D. = 1.73) out of five questions. The news perceptions of COVID-19 (Beta = 0.314, P = 0.01) and the chance of contracting COVID-19 (Beta= 0.130, P = 0.01). Conclusion: This study provides useful data to identify the probability of the students taking the COVID- 19 vaccine. Consistency is essential to promote good knowledge and attitude in taking the COVID19 vaccine.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91175158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/ijmsph.2021.07073202121072021
Worraprat Wuttisan
{"title":"Knowledge, attitude, and drug-resistant preventive behavior of university students: A study among university students in Chonburi, Thailand","authors":"Worraprat Wuttisan","doi":"10.5455/ijmsph.2021.07073202121072021","DOIUrl":"https://doi.org/10.5455/ijmsph.2021.07073202121072021","url":null,"abstract":"","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89416761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/ijmsph.2021.07071202111082021
Lipda Chantayasakorn
{"title":"Mutations in genes onset the disease of cancer","authors":"Lipda Chantayasakorn","doi":"10.5455/ijmsph.2021.07071202111082021","DOIUrl":"https://doi.org/10.5455/ijmsph.2021.07071202111082021","url":null,"abstract":"","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75019967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5455/IJMSPH.2020.12180202008012021
Sowmya Bh, U. D.
Background: Diabetes mellitus (DM) is a chronic metabolic disease which leads to dysfunction in the insulin production/insulin action or both. Hyperglycemia condition in DM results in oxidative stress with decreased antioxidants which leads to various diabetes-related complications. Natural antioxidants are considered to be very effective in preventing hyperglycemia due to the presence of chemical constituents in it. Aims and Objectives: This study aims to investigate the antidiabetic and ameliorative efficacy of two varieties of Psidium guajava L. (PG), namely, Lalit (LA) and Allahabad safeda (AS) in preventing complications in type 2 diabetes in albino rats. Materials and Methods: Matured male albino rats were randomly divided into four groups of six animals (n = 6) each. The first group of rats was served as control. The second group of rats was injected with 45 mg/kg/bw of streptozotocin (STZ) intraperitoneally for the induction of diabetes. The third and fourth groups of STZ-induced rats were supplemented with 200 mg/kg/bw of fruit extract of LA and 400 mg/ kg/bw fruit extract of AS through oral gavage for 8 weeks, respectively. Results: Significant elevation in lipid peroxidation (LPO) levels, reduced activities of superoxide dismutase, catalase, reduced glutathione (GSH), and GSH peroxides (GPx) in pancreas of diabetic-induced albino rats in contrast to controls. However, except the activity of GPx, treatment of 200 mg/kg/bw of LA significantly prevented the above changes. In comparison, the fruit extract of AS (400 mg/kg/bw) could not prevent diabetes-induced alterations in antioxidant enzymes and LPO levels. Conclusion: Our findings clearly indicate, fruit extract of LA of PG is potent enough to prevent oxidative stress in diabetic rats compared to AS. Thus, LA fruit extract could be used as natural antidiabetic in DM.
{"title":"Antidiabetic and ameliorative efficacy of two varieties of Psidium guajava L. fruit extracts in type 2 diabetes and indices of complications in diabetic albino rats","authors":"Sowmya Bh, U. D.","doi":"10.5455/IJMSPH.2020.12180202008012021","DOIUrl":"https://doi.org/10.5455/IJMSPH.2020.12180202008012021","url":null,"abstract":"Background: Diabetes mellitus (DM) is a chronic metabolic disease which leads to dysfunction in the insulin production/insulin action or both. Hyperglycemia condition in DM results in oxidative stress with decreased antioxidants which leads to various diabetes-related complications. Natural antioxidants are considered to be very effective in preventing hyperglycemia due to the presence of chemical constituents in it. Aims and Objectives: This study aims to investigate the antidiabetic and ameliorative efficacy of two varieties of Psidium guajava L. (PG), namely, Lalit (LA) and Allahabad safeda (AS) in preventing complications in type 2 diabetes in albino rats. Materials and Methods: Matured male albino rats were randomly divided into four groups of six animals (n = 6) each. The first group of rats was served as control. The second group of rats was injected with 45 mg/kg/bw of streptozotocin (STZ) intraperitoneally for the induction of diabetes. The third and fourth groups of STZ-induced rats were supplemented with 200 mg/kg/bw of fruit extract of LA and 400 mg/ kg/bw fruit extract of AS through oral gavage for 8 weeks, respectively. Results: Significant elevation in lipid peroxidation (LPO) levels, reduced activities of superoxide dismutase, catalase, reduced glutathione (GSH), and GSH peroxides (GPx) in pancreas of diabetic-induced albino rats in contrast to controls. However, except the activity of GPx, treatment of 200 mg/kg/bw of LA significantly prevented the above changes. In comparison, the fruit extract of AS (400 mg/kg/bw) could not prevent diabetes-induced alterations in antioxidant enzymes and LPO levels. Conclusion: Our findings clearly indicate, fruit extract of LA of PG is potent enough to prevent oxidative stress in diabetic rats compared to AS. Thus, LA fruit extract could be used as natural antidiabetic in DM.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"42 1","pages":"599-603"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77978558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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