Associations of Leptin and Adiponectin in Irritable Bowel Syndrome Patients with Overweight and Obesity

M. M. Fedorin, M. Livzan, O. Gaus
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Abstract

Irritable bowel syndrome (IBS) in overweight and obese individuals is characterized by a more severe course than in patients with normal weight. The purpose. To assess the level of adipokines (leptin and adiponectin) in blood serum, the correlation of these laboratory markers with the clinical manifestations of IBS, quality of life, eating habits, and signs of anxiety and depression based on the results of using a special questionnaire in patients with IBS. Material and methods. An open cohort cross-sectional study was conducted with the inclusion of 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 obese or overweight IBS patients aged 18 to 44 years (mean age 30.63 ± 6.37 years, BMI 25.88 ± 6.28 kg/m2). In group 1, subgroup 1A included 50 people with IBS associated with overweight or obesity. In subgroup 1B – 50 people suffering from IBS, with normal weight. Group 2 included 75 people without IBS, aged 19 to 43 years (mean age 29.31 ± 5.81 years, BMI 27.80 ± 6.20 kg/m2). Subgroup 2A included 50 non-IBS participants who were overweight or obese. Subgroup 2B included 25 apparently healthy participants. IBS symptoms were assessed using a 10-point scale. Using verified questionnaires, the severity of gastrointestinal symptoms, the presence of anxiety and depression, the level of specific anxiety, quality of life and eating habits were assessed. Results. IBS patients with overweight and obesity are characterized by higher levels of leptin and low levels of adiponectin than patients with normal weight (Mann – Whitney test, p < 0.05). Adipokine levels correlate with high cravings for sweet, fatty, starchy, and salty foods. A higher concentration of leptin is characteristic of patients suffering from IBS with a predominance of constipation (Mann – Whitney test, p < 0.05). High levels of leptin and low levels of adiponectin in overweight and obese IBS patients correlate with more severe symptoms of abdominal pain, flatulence, poor quality of life, and more frequent signs of anxiety and depression (Spirmen test p < 0.05, Mann – Whitney test, p < 0.05). Conclusion. The results obtained suggest a significant role of adipokines in the formation of more severe symptoms in IBS patients with overweight and obesity compared to patients with normal weight
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瘦素和脂联素与肠易激综合征超重和肥胖患者的关系
肠易激综合征(IBS)在超重和肥胖个体的特点是更严重的病程比正常体重的患者。的目的。为了评估血清中脂肪因子(瘦素和脂联素)的水平,以及这些实验室标记物与肠易激综合征临床表现、生活质量、饮食习惯、焦虑和抑郁症状的相关性,基于对肠易激综合征患者的特殊问卷调查结果。材料和方法。一项开放队列横断面研究纳入175名年龄在18至44岁(平均年龄30.06±6.15岁)的参与者。组1纳入100例18 ~ 44岁的肥胖或超重IBS患者(平均年龄30.63±6.37岁,BMI 25.88±6.28 kg/m2)。在第一组中,1A亚组包括50名伴有超重或肥胖的肠易激综合征患者。在1B亚组中,50人患有肠易激综合征,体重正常。2组无IBS患者75例,年龄19 ~ 43岁(平均年龄29.31±5.81岁,BMI 27.80±6.20 kg/m2)。亚组2A包括50名超重或肥胖的非肠易激综合征参与者。2B亚组包括25名表面健康的参与者。IBS症状采用10分制进行评估。通过验证问卷,对胃肠道症状的严重程度、焦虑和抑郁的存在、特定焦虑的水平、生活质量和饮食习惯进行了评估。结果。IBS合并超重和肥胖患者瘦素水平高于正常体重患者,脂联素水平较低(Mann - Whitney检验,p < 0.05)。脂肪因子水平与对甜食、高脂肪食物、淀粉类食物和咸味食物的强烈渴望有关。高瘦素浓度是肠易激综合征患者以便秘为主的特征(Mann - Whitney检验,p < 0.05)。超重和肥胖IBS患者的高水平瘦素和低水平脂联素与更严重的腹痛、胀气、生活质量差以及更频繁的焦虑和抑郁症状相关(Spirmen检验p < 0.05, Mann - Whitney检验p < 0.05)。结论。所获得的结果表明,与正常体重的患者相比,脂肪因子在超重和肥胖的IBS患者中形成更严重症状方面发挥了重要作用
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