A Case of Lung Abscesses Secondary to Mucormycosis in a Diabetic Female Patient

Rabia Seher Alvi, K. Khan, Nausheen Saifullah, Sadhna Priya, Saifullah Rabia, Javed
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Abstract

Mucormycosis is a rapidly advancing and hazardous form of opportunistic infection usually starts in nose and/or paranasal sinuses after inhaling fungal spores. This infection is caused by Mucorales fungi which belong to the Zygomycetes class. The incidence of Mucormycosis is approximately 1.7 cases in 1 million. They more frequently exist in rhinomaxillary area and is a rare pulmonary disease of an opportunistic fungi, which is difficult to diagnose with an unpredictable response to treatment. They usually appear in individuals with immunocompromised states such as diabetes, long term use of corticosteroids, immunosuppressive therapy for solid organ and hematopoietic cell transplantation, and disorders like neutropenia are notably common risk factors. As a potential for relatively life-threatening condition, the disorders warrant an anticipatory approach.  We report here a case of pulmonary mucormycosis in uncontrolled diabetes presented with bilateral cavitary lesions in lungs that was first misdiagnosed as case of Pulmonary TB, later diagnosis was made on the basis of results of bronchoscopic biopsy, and was started on amphotericin and followed up with improvement of her symptoms.
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女性糖尿病患者继发毛霉菌病肺脓肿1例
毛霉菌病是一种进展迅速和危险的机会性感染形式,通常在吸入真菌孢子后开始于鼻子和/或鼻窦。这种感染是由粘毛菌引起的,它属于接合菌纲。毛霉病的发病率约为百万分之1.7。它们多见于鼻上颌区,是一种罕见的机会性真菌肺部疾病,诊断困难,治疗反应难以预测。它们通常出现在免疫功能低下的个体中,如糖尿病、长期使用皮质类固醇、实体器官和造血细胞移植的免疫抑制治疗以及中性粒细胞减少症等疾病是常见的危险因素。作为一种潜在的相对危及生命的疾病,这些疾病需要预先处理。我们在此报告一例未控制的糖尿病合并肺毛霉菌病,表现为双侧肺腔病变,最初被误诊为肺结核,后来根据支气管镜活检结果诊断,开始使用两性霉素,并随访症状改善。
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