The Stability Comparison of Whitening Containing Kojic Acid and Glycolid Acid with The Same Cream Base

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-03-18 DOI:10.31869/IJPR.V1I1.2429

Siska Ferilda

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Abstract

This study is an experimental study of stability of creams containing kojic acid and glycolic at 2% using the same cream base. Cream containing kojic acid and glycolic acid are often used as skin whitening. The cream made is observing changes in organoleptic properties, pH, viscosity and homogeneity in storage for 6 weeks. Observations of organoleptic properties including discoloration and cream odor, pH examination using pH meter, viscosity examination using viscometer Brookfield with a spindle speed of 20 rpm while for homogeneity examination using a metallograph with a magnification of 200x. The results showed that base creams and cream containing kojic acid showed better stability on organoleptic observations compared to cream containing glycolic acid. The pH of the cream containing kojic acid is less stable than the cream containing glycolic acid. Viscosity of cream containing kojic acid is more stable than cream containing glycolic acid. On homogeneity testing each cream looks homogeneous. In this study it can be concluded that cream containing kojic acid has better stability than cream containing glycolic acid.

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同一乳膏碱下含曲酸和乙醇酸的美白稳定性比较

本研究是使用相同的乳膏碱，对含有2%曲酸和乙醇酸的乳膏的稳定性进行实验研究。含有曲酸和乙醇酸的面霜常被用来美白皮肤。制作的乳膏在贮存6周后，观察其感官特性、pH值、粘度和均匀性的变化。观察包括变色和奶油气味在内的感官特性，使用pH计检查pH值，使用粘度计检查粘度，主轴转速为20 rpm，使用金相显微镜检查均匀性，放大倍数为200倍。结果表明，与含乙醇酸的乳膏相比，基础乳膏和含曲酸乳膏在感官观察上表现出更好的稳定性。含曲酸乳膏的pH值比含乙醇酸乳膏的pH值更不稳定。含有曲酸的乳膏粘度比含有乙醇酸的乳膏更稳定。在均匀性测试中，每个面霜看起来都是均匀的。本研究表明，含曲酸乳膏的稳定性优于含乙醇酸乳膏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Indonesian Journal of Pharmaceutical and Clinical Research

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