{"title":"Pharmacological investigation of an Ayurvedic formulation on testosterone propionate-induced benign prostatic hyperplasia rats","authors":"Soni Hardik, M. Hardik, Jani Deepti, Patel Ghanashyam","doi":"10.5455/JEIM.280314.OR.099","DOIUrl":null,"url":null,"abstract":"Objective: This study aimed to investigate the potenital effect of an Ayurvedic herbo-mineral formulation in a rat model of testosterone propionate-induced benign prostatic hyperplasia (BPH). Methods: Male Wistar rats weighing 180-250 g were used. The selected animals were divided into six groups where each group consisted of six animals. Experimentally BPH was developed by subcutaneous administration of testosterone propionate (3 mg/kg) dissolved in corn oil for 28 days. The tested herbo-mineral formulation was administered orally for 28 consecutive days at 90 mg/kg, once or twice daily in different groups. On 29 th day, Blood samples were collected to evaluate different parameters like blood urea nitrogen (BUN), serum creatinine, serum total protein, serum total cholesterol, serum albumin, serum globulin and serum A/G ratio. Prostate glands were dissected out for different prostatic parameters and histopathological examination. Results: The herbo-mineral formulation showed significant effect on urine output and different prostatic parameters. Significant changes in urine volume, prostate weight, prostate weight index, prostate length and prostate width were observed. In addition, positive effects on different biochemical parameters like BUN, serum creatinine, serum total protein, etc were recorded. The used formulation, at both dose levels, also showed significant reversal in histology of prostate glands when compared with disease control group. On the other hand, no side effects were observed according to the administered herbo-mineral formulation. Conclusion: The findings of this study concludes that Herbo-mineral formulation has promising effect on testosterone propionate-induced BPH in male wistar rats. © 2014 GESDAV","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"105 1","pages":"131-136"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental and Integrative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/JEIM.280314.OR.099","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
阿育吠陀配方对丙酸睾酮诱导的大鼠良性前列腺增生的药理学研究
目的:探讨阿育吠陀草药矿物制剂对丙酸睾酮诱导的良性前列腺增生(BPH)大鼠模型的潜在作用。方法:选用雄性Wistar大鼠,体重180 ~ 250 g。选择的动物被分成六组,每组由六只动物组成。实验通过皮下注射溶解于玉米油中的丙酸睾酮(3mg /kg) 28天来发展BPH。将所测试的草药矿物制剂以90 mg/kg的剂量连续口服28天,每天1次或2次。第29天采血,测定血清尿素氮(BUN)、血清肌酐、血清总蛋白、血清总胆固醇、血清白蛋白、血清球蛋白和血清A/G比等指标。切除前列腺,进行不同参数的前列腺病理检查。结果:中药矿物制剂对尿量及不同前列腺参数均有显著影响。尿量、前列腺重量、前列腺重量指数、前列腺长度和前列腺宽度均有显著变化。此外,还记录了对BUN、血清肌酐、血清总蛋白等不同生化指标的积极影响。与疾病对照组相比,在两种剂量水平下,所使用的制剂也显示出前列腺组织学的显著逆转。另一方面,根据给药的草药-矿物质配方,没有观察到副作用。结论:中药矿物制剂对丙酸睾酮诱导的雄性wistar大鼠BPH有良好的治疗作用。©2014 gesdav
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