The Use of Abemaciclib in Combination with Aromatase Iinhibitors in Metastatic HR+ HER2/Neu-Negative Breast Cancer

D. Yukalchuk, D. M. Ponomarenko, T.N. Yukalchuk, S. S. Sidorova, A.V. Shevchuk, A. Novopashin, S. Prokopchuk, G.N. Tepikina
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Abstract

The article presents a clinical case illustrating the effectiveness of abemaciclib in combination with anastrozole in metastatic estrogen receptor-positive HER2/neu-negative breast cancer (BC). CDK4/6 inhibitors have changed the paradigm of treatment of patients with hormone-positive HER2 metastatic BC. Thanks to the ability of palbociclib, ribociclib and abemaciclib to delay and overcome resistance to endocrine therapy, the effectiveness of treatment of patients not only with newly diagnosed disease, but also with endocrine – resistant, and taking into account the independent effectiveness of abemaciclib and chemorefractor BC has increased. The combination of aromatase inhibitors and abemaciclib is associated with an increase in the effectiveness of treatment in the most prognostically unfavorable contingent of patients.
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Abemaciclib联合芳香化酶i抑制剂治疗转移性HR+ HER2/ new阴性乳腺癌
本文报道了一个临床病例,说明阿贝马昔利联合阿那曲唑治疗转移性雌激素受体阳性HER2/新阴性乳腺癌(BC)的有效性。CDK4/6抑制剂已经改变了激素阳性HER2转移性BC患者的治疗模式。由于palbociclib、ribociclib和abemaciclib延缓和克服内分泌治疗耐药的能力,不仅对新诊断的疾病,而且对内分泌耐药的患者,考虑到abemaciclib和化疗抗癌药BC的独立有效性,治疗的有效性有所提高。芳香化酶抑制剂和abemaciclib联合使用可提高预后最不利的患者的治疗效果。
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