Commentary on Covalent Tethering of Photo-responsive Superficial Layers on Hydrogel Surfaces

Lie Chen, Mingjie Liu
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Abstract

Volume 5 • Issue 3 • 1000229 Adv Tech Biol Med, an open access journal ISSN: 2379-1764 Hydrogels are widely used in the field related to biological medicine, such as drug carrier and drug delivery vehicle due to their excellent biocompatibility [1]. In the last two decades, hydrogels with diverse stimuli responsiveness were developed and utilized to construct the controlled release systems. However, conventionally strategies that are reported to prepare stimuli-responsive hydrogels usually suffer from complex preparation procedures [2-4] and the using of sol-gel transition process of the hydrogel to realize the controlled release would inevitably lead to the burst release [5-7]. Overcoming these limitations, we report a post-modified hydrogel with photo-controlled release property by covalent tethering of photo-responsive superficial layers on hydrogel surfaces in Chemical Science [8].
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水凝胶表面光响应浅层共价系缚研究进展
《Adv Tech Biol Med》,开放获取期刊,ISSN: 2379-1764水凝胶由于其优异的生物相容性,被广泛应用于药物载体、药物传递载体等生物医学相关领域。在过去的二十年中,具有不同刺激响应性的水凝胶被开发并用于构建控释系统。然而,传统的制备刺激响应型水凝胶的策略通常具有复杂的制备过程[2-4],并且利用水凝胶的溶胶-凝胶过渡过程来实现控制释放不可避免地会导致爆裂释放[5-7]。为了克服这些限制,我们在《化学科学》杂志上报道了一种具有光控释放特性的后修饰水凝胶,其方法是在水凝胶表面的光响应表面层上进行共价系缚。
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