SPECTROPHOTOMETRIC DETERMINATION OF TRIFLUOPERAZINE HYDROCHLORIDE USING DIAMMONIUM CERIUM NITRATE IN ITS PURE AND PHARMACEUTICAL FORM

Abstract

: Trifluoperazine hydrochloride (TFPH) is widely used in the treatment of some diseases such as hysteria, vomiting and schizophrenia. This study aims to develop a fast, easy, sensitive, accurate and economical spectrophotometric method for the determination of TFPH. This method included the reaction of TFPH with Diammonium Cerium Nitrate (CAN) in a medium with a pH value of 1 to form a complex. Parameters influencing the stability of the resulting complex (i.e. time; and temperature) were also investigated. The method depended on the UV spectrum at the wavelength of (499 nm) and the correlation coefficient of (R 2 = 0.9826). The results showed that the method has a good accuracy as (Rec% = 98.925), detection limit (0.408) and quantitative limit (1.361). The linearity range was 2-80 µg/mL. Moreover, this method has been successfully applied for the determination of the drug in its pure form and in its pharmaceutical preparation.