Deposition of Disodiun Cromoglycate and Salbutamol from a multiple-dose dry powder inhaler device

Abstract

Inhalation of drugs offers the opportunity to treat diseases of the respiratory tract. The use of dry powder inhalers is preferred to metered dose inhalers and nebulizers in this mode of drug delivery delivery. A multi-dose dry powder inhaler device, KCHALER TM  device, which delivers drugs passively into the respiratory tract, was developed in our laboratories. In this study, we report the deposition pattern of disodium cromoglycate and salbutamol obtained with the device in the Twin Impinger BP. The effect of type of mouthpiece attached to the KCHALER TM device, on respirable  fraction obtained with the Twin Impinger BP was also evaluated. The surface texture of carrier particles used in the formulation of the inhalation mixes and type of mouthpiece, affected the respirable fraction obtained in mixtures containing salbutamol and disodium cromoglycate. Keywords: Dry powder inhalers, multiple-dose dry powder inhaler device, salbutamol deposition, Twin impinger BP Journal of Pharmaceutical and Allied Sciences , Vol. 7 No. 1 (2010)