Stress Protein Expression in Bladder Tumors Tissues

Abstract

This study was designed to compare between the stress protein HSP70immunoexpression in the urinary bladder cancer (UBC) and bladder benign tumor(BT) , and to show the association between its immunoexpression and the clinicalgrades in bladder cancer . Paraffin Sections tissues from 50- bladder cancer tissuesand 15-bladder benign tumor tissues included in this study, Immunohistochemicaltechnique was done to detect the immunostaining of stress protein HSP-70 . Theresults indicated that (HSP70) proteins were significantly high expressed in BCcompared with BT patients HSP70 (74 % versus 33.3 % ; p≤ 0.01) , and thepatients with high grades cancer assume elevated positive IHC results compare topatients with low grades cancer with significant difference (p≤ 0.01) .Accordingly,HSP70 can be investigated as an omen biomarker in bladder cancer .Key Words: HSP70, IHC, Bladder Tumors.