{"title":"Trientine increases fecal copper excretion in Wilson's disease: A case report","authors":"Shozo Ishikawa, Shozo Nomoto, Kunihiro Yoshida, Takahiko Tokuda, Shu-ichi Ikeda","doi":"10.1002/jtra.1051","DOIUrl":null,"url":null,"abstract":"<p>A copper balance study was performed during the successive 7 days when a patient with Wilson's disease went on a low-copper diet and was taking 1500 mg of trientine daily. The average copper intake was 944 μg/day, urine copper excretion was 503 μg/day, fecal copper excretion was 922 μg/day; therefore, trientine reduced body copper about 500 μg per day. We provide direct evidence that trientine maintains copper balance probably by enhancing both the urinary and fecal excretion, with a larger amount decoppered in the feces. J. Trace Elem. Exp. Med. 14:405–407, 2001. © 2001 Wiley-Liss, Inc.</p>","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"14 4","pages":"405-407"},"PeriodicalIF":0.0000,"publicationDate":"2001-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.1051","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Trace Elements in Experimental Medicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jtra.1051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A copper balance study was performed during the successive 7 days when a patient with Wilson's disease went on a low-copper diet and was taking 1500 mg of trientine daily. The average copper intake was 944 μg/day, urine copper excretion was 503 μg/day, fecal copper excretion was 922 μg/day; therefore, trientine reduced body copper about 500 μg per day. We provide direct evidence that trientine maintains copper balance probably by enhancing both the urinary and fecal excretion, with a larger amount decoppered in the feces. J. Trace Elem. Exp. Med. 14:405–407, 2001. © 2001 Wiley-Liss, Inc.
曲恩汀增加威尔逊氏病患者粪铜排泄1例报告
在连续7天内进行了一项铜平衡研究，当一名威尔逊病患者进行低铜饮食，每天服用1500毫克的曲安汀。平均铜摄入量为944 μg/d，尿铜排泄量为503 μg/d，粪铜排泄量为922 μg/d;因此，曲恩汀每天可减少体内铜约500 μg。我们提供的直接证据表明，曲恩汀可能通过促进尿液和粪便的排泄来维持铜平衡，粪便中有大量的脱铜。J. Trace Elem。中华医学杂志，2001,14(4):555 - 557。©2001 Wiley-Liss, Inc。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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