Associated clinical factors of diabetic complications in Chinese patients with Type 2 diabetes

Xiaojing Wang, Wenying Zhao, Meihua Ji, D. Zhao
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Abstract

Background: The prevalence of the metabolic syndrome (MetS) is high among Chinese patients with type 2 diabetes. There is limited evidence in understanding the relationships between individual-level clinical indicators of MetS and diabetes complications among Chinese patients with Type 2 diabetes. Aims and Objectives: This study described the characteristics of patients with Type 2 diabetes in terms of the prevalence of MetS and clinical factors related to the common diabetes complications. Materials and Methods: Patients (n = 402) with Type 2 diabetes admitted to a tertiary hospital in Beijing were included in the study. Using patients' retrospective data, logistic regression was applied to determine the associated clinical factors of common diabetic complications. Results: In this sample, the prevalence of MetS was 84.3%, with the prevalence of diabetic peripheral neuropathy, microvascular, and macrovascular complications being 59.7%, 63.4%, and 61.7%, respectively. Our results showed that the diastolic blood pressure was significantly associated with diabetic retinopathy, while the levels of C peptide and fasting glucose were significantly related to diabetic nephropathy. Meanwhile, the regression also showed that the waist to hip ratio (WHR) is a significant indicator for the development of macrovascular complications. A 0.1 increase in the WHR will increase the chances of having carotid artery disease by 1.29 folds. Conclusion: The current study demonstrates that the prevalence of MetS and the common diabetic complications are relevantly high in this sample. Our findings suggest that reducing the WHR, controlling blood pressure, and improving glycemic control following clinical guidelines are essential to prevent or slow the progression of diabetes complications among patients with Type 2 diabetes.
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中国2型糖尿病患者糖尿病并发症的相关临床因素
背景:代谢综合征(MetS)在中国2型糖尿病患者中的患病率很高。在了解中国2型糖尿病患者个体水平的MetS临床指标与糖尿病并发症之间的关系方面,证据有限。目的和目的:本研究描述了2型糖尿病患者在MetS患病率和与常见糖尿病并发症相关的临床因素方面的特征。材料与方法:选取北京市某三级医院住院的2型糖尿病患者402例。利用患者回顾性资料,采用logistic回归分析确定糖尿病常见并发症的相关临床因素。结果:本组患者met患病率为84.3%,糖尿病周围神经病变患病率为59.7%,微血管患病率为63.4%,大血管并发症患病率为61.7%。我们的研究结果显示,舒张压与糖尿病视网膜病变显著相关,而C肽和空腹血糖水平与糖尿病肾病显著相关。同时,回归还显示腰臀比(WHR)是大血管并发症发生的重要指标。腰宽比每增加0.1,颈动脉疾病的可能性就会增加1.29倍。结论:目前的研究表明,该样本中MetS和常见糖尿病并发症的患病率较高。我们的研究结果表明,根据临床指南降低腰宽比、控制血压和改善血糖控制对于预防或减缓2型糖尿病患者糖尿病并发症的进展至关重要。
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