Factors leading to the development of osteoporosis in patients with ischemic heart disease in combination with rheumatoid arthritis

Abstract

Rheumatoid arthritis is a systemic disease of unclear etiology with autoimmune pathogenesis, which is characterized by chronic erosive polyarthritis. In some patients with rheumatoid arthritis, there is a dis-crepancy between the processes of bone resorption and bone formation, which is the cause of secondary metabolic osteopathy. A complication of rheumatoid arthritis with a change in bone quality is osteoporosis. Reduced bone density and an increased risk of fractures in osteoporosis determine the adverse course and significantly worsen the prognosis of the disease. IHD in combination with rheumatoid arthritis ag-gravates risk factors, leading to a decrease in bone density and an increased risk of fractures in osteoporosis, which determines the unfavorable course and significantly worsens the prognosis of the disease. At the present time, a number of studies the association of an increased risk of osteoporosis with the pres-ence of the following factors in patients with IHD in combination with rheumatoid arthritis has been re-vealed: low bone mineral density, female sex, age 65 years, early menopause, weight less than 57 kg, family history of osteoporosis, previous fractures, prolonged the course of rheumatoid arthritis and irra-tional therapy with glucocorticosteroids. This article presents the results of an analysis of the factors that lead to the development of osteoporosis in patients with ischemic heart disease in combination with rheumatoid arthritis who are inpatient treatment in the rheumatological department. сердечно-сосудистые