Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-301-308
A. Evgeny
One of the fields of modern dentistry is prevention and treatment of dental diseases in groups of people at higher risk, one of which is pregnant women. Pregnancy results in various types of complex adaptive and protective changes in the endocrine, cardiovascular, nervous and other systems of the body, that leads to deterioration in dental and periodontal health. These changes are further aggravated and become more aggressive in case of pregnancy affected by any pre-existing systemic disease. Disorders occurring in dia betes mellitus result in abnormal pregnancy, substantial deterioration of enamel condition, fast developing and complicated caries. At the moment, the high prevalence and multiple complications related to dental caries in diabetic pregnancy remain an open problem in dentistry and necessitate development and intro duction of new and effective methods of diagnosis, treatment and prevention of this pathology into clini cal practice of dental practitioners. A study has been carried by the author to improve diagnostic methods and treatment and preventive measures upon faults in structural and functional acid endurance of enamel and dental caries in diabetic pregnant women. The study revealed deterioration of tooth health, the high prevalence of caries and decay of calcium and phosphorus content in saliva of diabetic pregnant women in comparison with non-diabetics pregnant women. Sufficient efficacy of the drug on the basis of mineral complex (Calcide Magnesium) has been confirmed.
{"title":"DIAGNOSTICS AND TREATMENT AND PREVENTION MEASURES UPON FAULTS IN STRUCTURAL AND FUNCTIONAL ACID ENDURANCE OF ENAMEL AND DENTAL CARIES IN PREGNANT WOMEN WITH ENDOCRINE PATHOLOGIES (DIABETES MELLITUCE)","authors":"A. Evgeny","doi":"10.18413/2075-4728-2019-42-3-301-308","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-301-308","url":null,"abstract":"One of the fields of modern dentistry is prevention and treatment of dental diseases in groups of people at higher risk, one of which is pregnant women. Pregnancy results in various types of complex adaptive and protective changes in the endocrine, cardiovascular, nervous and other systems of the body, that leads to deterioration in dental and periodontal health. These changes are further aggravated and become more aggressive in case of pregnancy affected by any pre-existing systemic disease. Disorders occurring in dia betes mellitus result in abnormal pregnancy, substantial deterioration of enamel condition, fast developing and complicated caries. At the moment, the high prevalence and multiple complications related to dental caries in diabetic pregnancy remain an open problem in dentistry and necessitate development and intro duction of new and effective methods of diagnosis, treatment and prevention of this pathology into clini cal practice of dental practitioners. A study has been carried by the author to improve diagnostic methods and treatment and preventive measures upon faults in structural and functional acid endurance of enamel and dental caries in diabetic pregnant women. The study revealed deterioration of tooth health, the high prevalence of caries and decay of calcium and phosphorus content in saliva of diabetic pregnant women in comparison with non-diabetics pregnant women. Sufficient efficacy of the drug on the basis of mineral complex (Calcide Magnesium) has been confirmed.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81313179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-327-335
А. А. Ворожко, А. Клемин, Э. А. Майлян, A. A. Vorozhko, V. A. Klyomin
In 72 % of cases, acrylic plastics are used for the manufacture of dentures, despite the fact that it can cause the denture stomatitis, among which the inflammatory reactions of allergic genesis are most relevant. The results of various studies indicate that allergic intolerance to denture materials is growing every year, and now the prevalence of denture stomatitis reaches 40 %. In order to create a mathematical model for calculating the risk of developing stomatitis on removable acrylic dentures, 54 patients aged 42 to 88 years were examined. The symptoms of stomatitis were recorded 1 month after the installation of the denture. Immediately prior the denture treatment, an anamnesis was studied and laboratory testing was performed. Oral fluid (IL-4, TNF-a and sIgA) and blood serum (IL-4, TNF-a, sIgA, total IgE, total IgG4) were studied. Allergological diagnostics included the determination of IgE and IgG classes specific for acrylic antibodies, as well as the performance of RTML with methyl methacrylate monomer. For statistical data processing, the methods of rank correlation of Kendall and binary logistic regression were used. 1 month after prosthetics, the symptoms of stomatitis were identified in 29.6% of cases. The development of denture stomatitis depended (p <0.05) on the presence of an allergic disease in patients (t = 0.32), thyroid pathology ( t = 0.20), chemical adverse factors in the workplace (t = 0.20), and on the initial concentrations of IL-4 (t = 0.31) and total IgE ( t = 0.24) in blood serum. The mathematical model for calculating the risk of denture stomatitis, created using the method of binary logistic regression, includes the use of allergy history and IL-4 concentrations in blood serum as predictors. The total share of correctly predicted results using the developed model is 78.4 %. The obtained data should be used in practical public health to predict the development of denture stomatitis. Ключевые Variables in the binary logistic regression equation to describe the likelihood prosthetic stomatitis
{"title":"PREDICTION OF STOMATITIS DEVELOPMENT IN PATIENTS AFTER ACRYLIC DENTURE TREATMENT","authors":"А. А. Ворожко, А. Клемин, Э. А. Майлян, A. A. Vorozhko, V. A. Klyomin","doi":"10.18413/2075-4728-2019-42-3-327-335","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-327-335","url":null,"abstract":"In 72 % of cases, acrylic plastics are used for the manufacture of dentures, despite the fact that it can cause the denture stomatitis, among which the inflammatory reactions of allergic genesis are most relevant. The results of various studies indicate that allergic intolerance to denture materials is growing every year, and now the prevalence of denture stomatitis reaches 40 %. In order to create a mathematical model for calculating the risk of developing stomatitis on removable acrylic dentures, 54 patients aged 42 to 88 years were examined. The symptoms of stomatitis were recorded 1 month after the installation of the denture. Immediately prior the denture treatment, an anamnesis was studied and laboratory testing was performed. Oral fluid (IL-4, TNF-a and sIgA) and blood serum (IL-4, TNF-a, sIgA, total IgE, total IgG4) were studied. Allergological diagnostics included the determination of IgE and IgG classes specific for acrylic antibodies, as well as the performance of RTML with methyl methacrylate monomer. For statistical data processing, the methods of rank correlation of Kendall and binary logistic regression were used. 1 month after prosthetics, the symptoms of stomatitis were identified in 29.6% of cases. The development of denture stomatitis depended (p <0.05) on the presence of an allergic disease in patients (t = 0.32), thyroid pathology ( t = 0.20), chemical adverse factors in the workplace (t = 0.20), and on the initial concentrations of IL-4 (t = 0.31) and total IgE ( t = 0.24) in blood serum. The mathematical model for calculating the risk of denture stomatitis, created using the method of binary logistic regression, includes the use of allergy history and IL-4 concentrations in blood serum as predictors. The total share of correctly predicted results using the developed model is 78.4 %. The obtained data should be used in practical public health to predict the development of denture stomatitis. Ключевые Variables in the binary logistic regression equation to describe the likelihood prosthetic stomatitis","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88916009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-263-272
Людмила Валентиновна Васильева, В. Г остева, А.В. Никитин, S. V. Zhemchuzhikov, L. Vasilieva, E. Gosteva
Currently, the increasing social importance of studying the quality of life of persons with obesity, in accordance with the national clinical guidelines for the diagnosis, treatment, prevention of obesity and associated diseases, the social importance of studying the quality of life. The aim of the work is to increase the effectiveness of treatment of patients with obesity and coronary heart disease (CHD) by including perindopril in therapy. Material. An open randomized study to improve the effectiveness of treatment of 84 patients with coronary heart disease in combination with obesity I-II art., of which 45 women and 39 men, the average age was (56,2 ± 4,8) years. Results. The patients were randomized into groups: the first 42 patients received perindopril in the complex therapy at a dose of 10 mg per day for 6 months, the second standard drug therapy. We used the Russian version of the SF-36 questionnaire. As a result of complex therapy in group 1, there was a significant (p < 0,05) increase in НАУЧНЫЕ ВЕДОМОСТИ | | Серия: Медицина. Фармация. 2019. Том 42, No 3 263 264 НАУЧНЫЕ ВЕДОМОСТИ М Н Серия: Медицина. Фармация. 2019. Том 42, No 3 quality of life on five studied scales of the SF-36 questionnaire (General Health -by 16 points, 40 %; Vitality by 15,9 points, 48 %; Physical Functioning by 29,5 points, 85 %; Sosial Functioning 10,2 points, 20 %; Role-Physical 17,8 points, 45 %), the indicator of the pain intensity scale significantly decreased (Body Pain by 24 score, 48 %). In group 2, there was also an improvement in all indicators of quality of life, which did not reach the degree of reliability, a significant (p < 0,05) decrease by 35 % of the pain intensity index (17,4 points). Conclusion. An effective method of treatment of patients with CHD and obesity is the inclusion of perindopril 10 mg/day in this cohort of patients. Ключевые слова: ишемическая болезнь сердца, ожирение, качество жизни, периндоприл.
{"title":"EFFECT OF PERINDOPRIL ON THE QUALITY OF LIFE WITH COMORBIDITY OF OBESITY AND CORONARY HEART DISEASE","authors":"Людмила Валентиновна Васильева, В. Г остева, А.В. Никитин, S. V. Zhemchuzhikov, L. Vasilieva, E. Gosteva","doi":"10.18413/2075-4728-2019-42-3-263-272","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-263-272","url":null,"abstract":"Currently, the increasing social importance of studying the quality of life of persons with obesity, in accordance with the national clinical guidelines for the diagnosis, treatment, prevention of obesity and associated diseases, the social importance of studying the quality of life. The aim of the work is to increase the effectiveness of treatment of patients with obesity and coronary heart disease (CHD) by including perindopril in therapy. Material. An open randomized study to improve the effectiveness of treatment of 84 patients with coronary heart disease in combination with obesity I-II art., of which 45 women and 39 men, the average age was (56,2 ± 4,8) years. Results. The patients were randomized into groups: the first 42 patients received perindopril in the complex therapy at a dose of 10 mg per day for 6 months, the second standard drug therapy. We used the Russian version of the SF-36 questionnaire. As a result of complex therapy in group 1, there was a significant (p < 0,05) increase in НАУЧНЫЕ ВЕДОМОСТИ | | Серия: Медицина. Фармация. 2019. Том 42, No 3 263 264 НАУЧНЫЕ ВЕДОМОСТИ М Н Серия: Медицина. Фармация. 2019. Том 42, No 3 quality of life on five studied scales of the SF-36 questionnaire (General Health -by 16 points, 40 %; Vitality by 15,9 points, 48 %; Physical Functioning by 29,5 points, 85 %; Sosial Functioning 10,2 points, 20 %; Role-Physical 17,8 points, 45 %), the indicator of the pain intensity scale significantly decreased (Body Pain by 24 score, 48 %). In group 2, there was also an improvement in all indicators of quality of life, which did not reach the degree of reliability, a significant (p < 0,05) decrease by 35 % of the pain intensity index (17,4 points). Conclusion. An effective method of treatment of patients with CHD and obesity is the inclusion of perindopril 10 mg/day in this cohort of patients. Ключевые слова: ишемическая болезнь сердца, ожирение, качество жизни, периндоприл.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85406215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-273-278
. А. Викторова, В В Голошубина, Ирина Александровна Гришечкина, С. Бунова, I. Viktorova, V. Goloshubina, I. Grishechkina, S. Bunova
A clinical case of fever of unknown origin in a 80-year-old patient who was treated in the hospital (thoracic, surgical, therapeutic department) for 4 months with a diagnosis of fever of unknown genesis. Chronic obstructive pulmonary disease Stage 3, exacerbation. Bullous emphysema. Chronic pulmonary heart decompensation. Respiratory failure II. Coronary heart disease. Postinfarction cardiosclerosis without further elaboration. Arterial hypertension, stage III, risk 4 (very high). Aortic heart disease: stenosis and insufficiency. Chronic heart failure IIA FC III. Cholelithiasis. Chronic calculous cholecystitis. Benign prostatic hyperplasia. Chronic cystitis. Chronic pyelonephritis. Chronic kidney disease. Stage Glomerular filtration 25 ml/min/1,73 m2. Anemia is severe, and died with symptoms of increasing multiorgan failure is considered. The errors of the lifetime diagnosis of systemic vasculitis, in particular Wegener's granulomatosis, are analyzed. The importance of an expanded definition of antineutrophilic cytoplasmic antibodies (ANCA) is emphasized, in particular, to proteinase-3. It was noted that a biopsy in a patient with a fever of unknown genesis and multiorgan lesions, as well as an extended study of the spectrum of the ANCA, could be a decisive factor in the lifetime diagnosis of Wegener’s granulomatosis. It is concluded that a negative result on ANCA to myeloperoxidase should not stop further diagnostic search.
{"title":"DIFFICULTIES AND MISTAKES IN THE DIAGNOSIS OF THE ROOT CAUSES OF FEVER OF UNKNOWN GENESIS (CLINICAL CASE)","authors":". А. Викторова, В В Голошубина, Ирина Александровна Гришечкина, С. Бунова, I. Viktorova, V. Goloshubina, I. Grishechkina, S. Bunova","doi":"10.18413/2075-4728-2019-42-3-273-278","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-273-278","url":null,"abstract":"A clinical case of fever of unknown origin in a 80-year-old patient who was treated in the hospital (thoracic, surgical, therapeutic department) for 4 months with a diagnosis of fever of unknown genesis. Chronic obstructive pulmonary disease Stage 3, exacerbation. Bullous emphysema. Chronic pulmonary heart decompensation. Respiratory failure II. Coronary heart disease. Postinfarction cardiosclerosis without further elaboration. Arterial hypertension, stage III, risk 4 (very high). Aortic heart disease: stenosis and insufficiency. Chronic heart failure IIA FC III. Cholelithiasis. Chronic calculous cholecystitis. Benign prostatic hyperplasia. Chronic cystitis. Chronic pyelonephritis. Chronic kidney disease. Stage Glomerular filtration 25 ml/min/1,73 m2. Anemia is severe, and died with symptoms of increasing multiorgan failure is considered. The errors of the lifetime diagnosis of systemic vasculitis, in particular Wegener's granulomatosis, are analyzed. The importance of an expanded definition of antineutrophilic cytoplasmic antibodies (ANCA) is emphasized, in particular, to proteinase-3. It was noted that a biopsy in a patient with a fever of unknown genesis and multiorgan lesions, as well as an extended study of the spectrum of the ANCA, could be a decisive factor in the lifetime diagnosis of Wegener’s granulomatosis. It is concluded that a negative result on ANCA to myeloperoxidase should not stop further diagnostic search.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91415864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-349-355
Н. М. Агарков, С. Гонтарева, N. Agarkov, I. Gontareva
у детей AbstractChronic periodontitis in children is a common pathology that causes various complications. In the development of this disease, an important role is played by immunological reactions that are insufficiently studied. Immunological disorders were studied in 127 children in saliva aged 4-15 years, suffering from chronic periodontitis of moderate and severe degree. The control group consisted of 108 healthy children of the same age. Determination of interleukins in saliva was carried out by immuno-enzyme analyzer, and further calculation of their informativeness was performed. It was found that informative interleukins are IA-1, IL-2, IL-10. Based on informative interleukins, a discriminant model was developed that allows diagnosing chronic periodontitis in children with the required level for medical purposes. Arobaze created a discriminant model on the control sample showed good results. Erroneous diagnosis of chronic periodontitis in children in 9.6-9.8% of cases. The application of this model allows to diagnose chronic periodontitis in childhood at an early stage of the disease, since changes in the content of interleukins in saliva are detected in the first days of development of chronic periodontitis will prevent the occurrence of various complications.
{"title":"CHANGES IN INTERLEUKINS IN CHILDREN WITH CHRONIC PERIODONTITIS","authors":"Н. М. Агарков, С. Гонтарева, N. Agarkov, I. Gontareva","doi":"10.18413/2075-4728-2019-42-3-349-355","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-349-355","url":null,"abstract":"у детей AbstractChronic periodontitis in children is a common pathology that causes various complications. In the development of this disease, an important role is played by immunological reactions that are insufficiently studied. Immunological disorders were studied in 127 children in saliva aged 4-15 years, suffering from chronic periodontitis of moderate and severe degree. The control group consisted of 108 healthy children of the same age. Determination of interleukins in saliva was carried out by immuno-enzyme analyzer, and further calculation of their informativeness was performed. It was found that informative interleukins are IA-1, IL-2, IL-10. Based on informative interleukins, a discriminant model was developed that allows diagnosing chronic periodontitis in children with the required level for medical purposes. Arobaze created a discriminant model on the control sample showed good results. Erroneous diagnosis of chronic periodontitis in children in 9.6-9.8% of cases. The application of this model allows to diagnose chronic periodontitis in childhood at an early stage of the disease, since changes in the content of interleukins in saliva are detected in the first days of development of chronic periodontitis will prevent the occurrence of various complications.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77762379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-356-363
. В. Чуев, Т. Джанашия, П. Рыжова, В. С. Штана, В Ю Денисова, V. Chuev, V. T. Janashia, I. Ryzhova, V. S. Shtana, V. Denisova
new requirements of the legislation the domestic manufacturer developed the new basic material "Belakril-E GO". Having passed the first clinical tests, specialists noted a specific smell of monomer, and as a result, long adaptation of patients to removable designs of dentures. This fact motivated on search of new ways of obtaining the best quality of an artificial limb, and need of improvement of manufacturing techniques. The purpose of this work was to improve manufacturing techniques of removable designs of dentures from besprekursorny basic polymer "Belakril-E GO" and to carry out comparison with the manufacturing techniques recommended by the producer. Samples were for this purpose made of new domestic besprekursorny basic polymer "Belakril-E GO" by different technologies: compression pressing, according to the instruction of the producer; molding formation; free casting; and the developed method. The received samples were studied regarding the content of residual monomer of methylmethacrylate in comparative aspect. The received results showed, the advanced manufacturing techniques of removable designs of dentures allow to improve their quality significantly. Ключевые слова: базисная пластмасса, метилметакрилат, этилметакрилат, съемные протезы, прекурсоры, наркотизм, технология.
{"title":"TECHNOLOGICAL ASPECTS OF WORK WITH NON-PRECURITY DENTAL POLYMERS","authors":". В. Чуев, Т. Джанашия, П. Рыжова, В. С. Штана, В Ю Денисова, V. Chuev, V. T. Janashia, I. Ryzhova, V. S. Shtana, V. Denisova","doi":"10.18413/2075-4728-2019-42-3-356-363","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-356-363","url":null,"abstract":"new requirements of the legislation the domestic manufacturer developed the new basic material \"Belakril-E GO\". Having passed the first clinical tests, specialists noted a specific smell of monomer, and as a result, long adaptation of patients to removable designs of dentures. This fact motivated on search of new ways of obtaining the best quality of an artificial limb, and need of improvement of manufacturing techniques. The purpose of this work was to improve manufacturing techniques of removable designs of dentures from besprekursorny basic polymer \"Belakril-E GO\" and to carry out comparison with the manufacturing techniques recommended by the producer. Samples were for this purpose made of new domestic besprekursorny basic polymer \"Belakril-E GO\" by different technologies: compression pressing, according to the instruction of the producer; molding formation; free casting; and the developed method. The received samples were studied regarding the content of residual monomer of methylmethacrylate in comparative aspect. The received results showed, the advanced manufacturing techniques of removable designs of dentures allow to improve their quality significantly. Ключевые слова: базисная пластмасса, метилметакрилат, этилметакрилат, съемные протезы, прекурсоры, наркотизм, технология.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77789775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-279-289
Ольга Александровна Осипова, Е. В. Добромирова, А. И. Головин, О.Н. Белоусова, O. Osipova, E. V. Dobromirovа, A. Golovin
This literature review presents current data on 3-hydroxy-3-methylglutaryl-CoAreductase inhibitors statins, as anti-inflammatory agents during atherogenesis. Molecular mechanisms responsible for the anti-inflammatory effects of statins are described, as well as clinical data on the non-lipid-lowering effect of statins on cardiovascular outcomes. Analyzed the results of a number of randomized clinical trials, including GREACE, ALLIANCE, TNT, PLANET I, PLANET II and meta-analyzes. Since, cardiovascular events and renal dysfunction are associated with increased morbidity, reduced quality of life and higher mortality rates. The prospects for further research are discussed to compare the clinical efficacy of statins (atorvastatin and rosuvastatin) in patients with acute coronary syndrome with ST elevation. The possible role of statins on endothelial cell function is discussed. The pleiotropic effects of the new generation of statins are actively explained. The possibility of the active use of statins in groups of patients of middle and senile age was also discussed. 280 НАУЧНЫЕ ВЕДОМОСТИ М Н Серия: Медицина. Фармация. 2019. Том 42, No 3 Ключевые слова: острый коронарный синдром, статины, хроническая болезнь почек.
本文综述了3-羟基-3-甲基戊二酰coreductase抑制剂他汀类药物在动脉粥样硬化过程中的抗炎作用。本文描述了他汀类药物抗炎作用的分子机制，以及他汀类药物对心血管结果的非降脂作用的临床数据。分析多项随机临床试验的结果，包括GREACE、ALLIANCE、TNT、PLANET I、PLANET II和meta分析。因此，心血管事件和肾功能障碍与发病率增加、生活质量下降和死亡率升高有关。进一步探讨他汀类药物(阿托伐他汀与瑞舒伐他汀)对急性冠状动脉综合征ST段抬高患者临床疗效的比较研究前景。讨论了他汀类药物对内皮细胞功能的可能作用。新一代他汀类药物的多效性得到了积极的解释。讨论了他汀类药物在中老年患者群体中积极应用的可能性。280 НАУЧНЫЕ ВЕДОМОСТИ М Н Серия: Медицина。Фармация。2019. Том42岁,3号Ключевыеслова:острыйкоронарныйсиндром,статины,хроническаяболезньпочек。
{"title":"NEPHROPROTECTIVE EFFECT OF BLOCKERS 3 GMCo-REDUCTASE IN PATIENTS WITH ACUTE CORONARY SYNDROME AFTER MYOCARDIAL REVASCULARIZATION BY THE METHOD OF THE TRANSGULAR CORONARY INTERVENTION","authors":"Ольга Александровна Осипова, Е. В. Добромирова, А. И. Головин, О.Н. Белоусова, O. Osipova, E. V. Dobromirovа, A. Golovin","doi":"10.18413/2075-4728-2019-42-3-279-289","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-279-289","url":null,"abstract":"This literature review presents current data on 3-hydroxy-3-methylglutaryl-CoAreductase inhibitors statins, as anti-inflammatory agents during atherogenesis. Molecular mechanisms responsible for the anti-inflammatory effects of statins are described, as well as clinical data on the non-lipid-lowering effect of statins on cardiovascular outcomes. Analyzed the results of a number of randomized clinical trials, including GREACE, ALLIANCE, TNT, PLANET I, PLANET II and meta-analyzes. Since, cardiovascular events and renal dysfunction are associated with increased morbidity, reduced quality of life and higher mortality rates. The prospects for further research are discussed to compare the clinical efficacy of statins (atorvastatin and rosuvastatin) in patients with acute coronary syndrome with ST elevation. The possible role of statins on endothelial cell function is discussed. The pleiotropic effects of the new generation of statins are actively explained. The possibility of the active use of statins in groups of patients of middle and senile age was also discussed. 280 НАУЧНЫЕ ВЕДОМОСТИ М Н Серия: Медицина. Фармация. 2019. Том 42, No 3 Ключевые слова: острый коронарный синдром, статины, хроническая болезнь почек.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90052317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-342-348
К. Леонтьев, А.В. Цимбалистов, А. Борозенцева, С. Мишина, В. Ю. Борозенцев, V. K. Leontiev, A. Tsymbalistov, V. A. Borozentseva, N. Mishina, V. Y. Borozentsev
The main factor in the destruction of fillings at the border with tooth enamel and the development of car ies is a violation of edge permeability. Using the electrometric method to study the state of the teeth, im portant, new information was obtained on the maturation of tooth enamel, on the diagnosis of tooth decay of enamel and dentin, damage to tooth pulp and periodontitis. Based on the materials of 297 clinical ob servations the change of electrical conductivity of hard tissues of teeth correlating with the depth of lesion was established. The use of electrometry of hard tissues of teeth can improve the efficiency of diagnosis of hidden forms of caries and its complications. The development of a new, accurate, reliable method for determining the edge permeability of fillings is a very important task in dentistry.
{"title":"ELECTRICAL CONDUCTIVITY OF ENAMEL OF INTACT TEETH AND EDGE PERMEABILITY OF FILLINGS IN THE TREATMENT OF CARIES","authors":"К. Леонтьев, А.В. Цимбалистов, А. Борозенцева, С. Мишина, В. Ю. Борозенцев, V. K. Leontiev, A. Tsymbalistov, V. A. Borozentseva, N. Mishina, V. Y. Borozentsev","doi":"10.18413/2075-4728-2019-42-3-342-348","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-342-348","url":null,"abstract":"The main factor in the destruction of fillings at the border with tooth enamel and the development of car ies is a violation of edge permeability. Using the electrometric method to study the state of the teeth, im portant, new information was obtained on the maturation of tooth enamel, on the diagnosis of tooth decay of enamel and dentin, damage to tooth pulp and periodontitis. Based on the materials of 297 clinical ob servations the change of electrical conductivity of hard tissues of teeth correlating with the depth of lesion was established. The use of electrometry of hard tissues of teeth can improve the efficiency of diagnosis of hidden forms of caries and its complications. The development of a new, accurate, reliable method for determining the edge permeability of fillings is a very important task in dentistry.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78417192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-290-300
{"title":"FEATURE THE EMPLOYMENT RATE AS ONE OF THE RISK FACTORS OF SEVERE FORMS OF CHRONIC ISCHEMIC HEART DISEASE","authors":"","doi":"10.18413/2075-4728-2019-42-3-290-300","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-290-300","url":null,"abstract":"","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91532243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.18413/2075-4728-2019-42-3-319-326
Н.А. Авхачева, N. A. Avkhacheva
In order for the provision of dental care was high quality, it needs to be tailored to a variety of systemic and chronic diseases from which the patients suffer. This feature of dental care is due to the fact that dif ferent approaches and methods of providing such assistance contributes, first of all, to improve the health of patients, improve their quality of life. The article describes the features of dental care for patients with chronic non-communicable diseases. According to the author, the Feedback of the dentist, endocrinologist and therapist also plays an important role in improving the quality of care for patients with diabetes, as the dentist taking into account the recommendations of the endocrinologist (the use of certain drugs) and timely referral to the dentist of such patients by the therapist and endocrinologist will allow regular moni toring of the state of the teeth and oral cavity of patients. The author comes to the conclusion that patients suffering from diabetes mellitus are included in a special group of dental patients who should be under special control of the dentist and receive his help in a timely manner to prevent the development of com plications of the underlying disease and dental pathologies. Ключевые слова: стоматологическая помощь, хронические неинфекционные заболевания, сахар ный диабет.
{"title":"FEATURES OF PROVIDING DENTAL CARE TO PATIENTS WITH CHRONIC NONCOMMUNICABLE DISEASES (FOR EXAMPLE DIABETES)","authors":"Н.А. Авхачева, N. A. Avkhacheva","doi":"10.18413/2075-4728-2019-42-3-319-326","DOIUrl":"https://doi.org/10.18413/2075-4728-2019-42-3-319-326","url":null,"abstract":"In order for the provision of dental care was high quality, it needs to be tailored to a variety of systemic and chronic diseases from which the patients suffer. This feature of dental care is due to the fact that dif ferent approaches and methods of providing such assistance contributes, first of all, to improve the health of patients, improve their quality of life. The article describes the features of dental care for patients with chronic non-communicable diseases. According to the author, the Feedback of the dentist, endocrinologist and therapist also plays an important role in improving the quality of care for patients with diabetes, as the dentist taking into account the recommendations of the endocrinologist (the use of certain drugs) and timely referral to the dentist of such patients by the therapist and endocrinologist will allow regular moni toring of the state of the teeth and oral cavity of patients. The author comes to the conclusion that patients suffering from diabetes mellitus are included in a special group of dental patients who should be under special control of the dentist and receive his help in a timely manner to prevent the development of com plications of the underlying disease and dental pathologies. Ключевые слова: стоматологическая помощь, хронические неинфекционные заболевания, сахар ный диабет.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87540551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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