Development of exhaled breath assay devices using Functionalized Quartz sensors

A.I. Palaniappan, T. Melissa, S. Moochhala, F. Tay, S. Mhaisalkar
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引用次数: 1

Abstract

This paper emphasizes on development of a sensitive and low cost exhaled breath assay device for clinical applications. Functionalized Quartz Crystal Microbalance (QCM) is used as the sensing platform to identify and quantify various bio-markers in the exhaled breath. Heme-based receptors, organic receptors, etc., will be functionalized on the quartz crystal electrodes to obtain the finger print of the various bio-markers in the exhaled breath. Animal model studies (e.g. urban smoke inhalation injury) have been carried out to validate the developed sensor system. Subsequently, a prototype for portable exhaled breath devices is illustrated using the developed sensor system.
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功能化石英传感器呼气检测装置的研制
本文着重于研制一种灵敏、低成本的临床呼气检测装置。利用功能化石英晶体微天平(QCM)作为传感平台,对呼出气体中的各种生物标志物进行识别和定量。血红素受体、有机受体等将在石英晶体电极上功能化,获取呼出气体中各种生物标记物的指纹。动物模型研究(如城市烟雾吸入性损伤)已经进行,以验证开发的传感器系统。随后,使用所开发的传感器系统说明了便携式呼气装置的原型。
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