A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review

Abhijita Talukder, C. Kalita, Nayanika Neog, Chayanika Goswami, Mrinal Kashyap Sarma, Iswar Hazarika
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引用次数: 7

Abstract

Abstract Since the identification of the genomic sequence of SARS-CoV-2, an unprecedented effort is being made until this date for the development of a safe and effective vaccine by pharma companies and laboratories worldwide. To attain herd immunity and quite possibly recover from this pandemic, which has claimed the life of about 4.23 million people, an exceptional effort has been made by the scientific community for the development of a vaccine. Various vaccines have been developed based on different platforms and each of them seems to possess its own merits and demerits based on its safety, immunogenicity, the durability of immunity, dosing schedule, technological platform, and ease of manufacture and transport. Based on these parameters this review aims to critically assess the efficacy of Covaxin and compare it with other vaccines in the WHO EUL list and perform a comparative analysis of COVID-19 vaccines which are in phase 3 and phase 4 of clinical trials. This will help us determine where COVAXIN stands against other vaccines and vaccine candidates based on these parameters which will ultimately help us determine the best vaccine that could potentially eradicate the COVID-19 pandemic.
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Covaxin与其他疫苗抗COVID-19安全性和有效性的比较分析
自SARS-CoV-2基因组序列被确定以来,全球制药公司和实验室正在以前所未有的努力开发安全有效的疫苗。为了获得群体免疫,并很可能从这场已夺去约423万人生命的大流行病中恢复过来,科学界为研制疫苗作出了非凡的努力。基于不同平台开发了各种疫苗,根据其安全性、免疫原性、免疫持久性、给药时间表、技术平台以及制造和运输的便利性,每种疫苗似乎都有自己的优缺点。根据这些参数,本综述旨在严格评估Covaxin的疗效,并将其与世卫组织EUL清单中的其他疫苗进行比较,并对处于3期和4期临床试验的COVID-19疫苗进行比较分析。这将有助于我们根据这些参数确定COVAXIN与其他疫苗和候选疫苗的区别,最终帮助我们确定可能根除COVID-19大流行的最佳疫苗。
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