S. Pol, V. Kadam, S. Jagtap, Sampada Bhosale, Nita Pawar, R. Gaikwad
{"title":"Identification of Potential Flavonoids against the Spleen Tyrosine Kinase to Treat Psoriasis: In Silico approach","authors":"S. Pol, V. Kadam, S. Jagtap, Sampada Bhosale, Nita Pawar, R. Gaikwad","doi":"10.52711/2231-5713.2023.00016","DOIUrl":null,"url":null,"abstract":"Now a day, phytochemicals are widely consideration for structure optimization programs which focuses on making more active and less toxic drug products. Psoriasis is an inflammatory, chronic, remitting and relapsing, genetically influenced skin disease. Variety of flavonoid structureswere used to find the potential molecules against the psoriasis. In this current study molecular docking studies were carried out to identify the flavonoids having good binding ability with the target protein of psoriasis. Docked ligands were subjected to identify the drug like properties using drug-likeness prediction. Findings suggested that 23 flavonoid structures may act against the psoriasis.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmacy and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52711/2231-5713.2023.00016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Now a day, phytochemicals are widely consideration for structure optimization programs which focuses on making more active and less toxic drug products. Psoriasis is an inflammatory, chronic, remitting and relapsing, genetically influenced skin disease. Variety of flavonoid structureswere used to find the potential molecules against the psoriasis. In this current study molecular docking studies were carried out to identify the flavonoids having good binding ability with the target protein of psoriasis. Docked ligands were subjected to identify the drug like properties using drug-likeness prediction. Findings suggested that 23 flavonoid structures may act against the psoriasis.