Manigundan Kaari, Jerrine Joseph, Sivarajan Anbalman, V. Angamuthu, A. Sreenivasan, G. Venugopal, R. Manikkam, Balagurunathan Ramasamy, WilsonAruni
{"title":"A multifunctional Streptomyces maritimus SACC-152 isolated from Andaman and Nicobar Islands, India.","authors":"Manigundan Kaari, Jerrine Joseph, Sivarajan Anbalman, V. Angamuthu, A. Sreenivasan, G. Venugopal, R. Manikkam, Balagurunathan Ramasamy, WilsonAruni","doi":"10.35841/2249-622X.71.15986","DOIUrl":null,"url":null,"abstract":"A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was investigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological and molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus. Bioactive metabolites from the strain SACC-152 were produced by submerged fermentation and extracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum of antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage (LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug sensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed promising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1 1","pages":"10-19"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Biomedical and Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35841/2249-622X.71.15986","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was investigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological and molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus. Bioactive metabolites from the strain SACC-152 were produced by submerged fermentation and extracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum of antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage (LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug sensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed promising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68
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