{"title":"An option for painful diabetic neuropathy with simultaneous 'antioxidative' and 'anesthetic' properties: topical Citrullus colocynthis","authors":"M. Heydari, M. Shams, K. Homayouni, A. Borhani-Haghighi, A. Salehi, M. H. Hashempur","doi":"10.5455/JEIM.031113.HP.009","DOIUrl":null,"url":null,"abstract":"Diabetic neuropathy is probably the most common complication of diabetes mellitus. Secondary preventive measures for diabetic neuropathy with delaying, stopping or even reversing progressive course of neuropathy, pain control and prevention of ulceration can play important role in diabetic patients care. Oxidative stress plays an important role in pathogenesis of diabetic neuropathy. Treatments for diabetic neuropathy have been mainly focused on two purposes, pain control and repair of nerve injury. Therapeutic options for nerve injuries may not improve or even exacerbate painful symptoms. On the other hand most of treatments for pain control have little or no effect on nerve function. As a result of mentioned discrepancy between ‘nerve protection’ and ‘pain control’ in the treatment of painful diabetic neuropathy, it is hypothesized that Citrullus colocynthis as a therapeutic agent with simultaneous antioxidative and anesthetic effects can play an important role in treatment of painful diabetic neuropathy. Previous in vitro and animal studies of C.colocynthis demonstrated its ‘antioxidative’, ‘anesthetic’ and ‘antiulcerogenic’ effects. A randomized controlled double-blind clinical trial is needed to evaluate this hypothesis. © 2014 GESDAV","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"223 1","pages":"9-12"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental and Integrative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/JEIM.031113.HP.009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
同时具有“抗氧化”和“麻醉”特性的疼痛性糖尿病神经病变的一种选择:外用香瓜多糖
糖尿病性神经病变可能是糖尿病最常见的并发症。糖尿病神经病变的二级预防措施,延缓、停止甚至逆转神经病变的进展过程,控制疼痛和预防溃疡,在糖尿病患者的护理中发挥重要作用。氧化应激在糖尿病神经病变的发病机制中起重要作用。糖尿病神经病变的治疗主要集中在疼痛控制和神经损伤修复两个方面。神经损伤的治疗方案可能不会改善甚至加重疼痛症状。另一方面,大多数控制疼痛的治疗对神经功能的影响很小或没有影响。鉴于上述“神经保护”与“疼痛控制”在疼痛性糖尿病神经病变治疗中的差异,我们假设瓜蒌多糖作为一种同时具有抗氧化和麻醉作用的治疗剂可能在疼痛性糖尿病神经病变的治疗中发挥重要作用。先前的体外和动物研究表明,colocynthis具有“抗氧化”、“麻醉”和“抗溃疡”作用。需要一项随机对照双盲临床试验来评估这一假设。©2014 gesdav
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