Anti-bacterial activity for trimethoprim and its complexes

Abstract

Background: The biological assessment of trimethoprim organotin complexes is the subject of the work discussed in this publication. Objective: The purpose of this project is to investigate the properties of trimethoprim tin complexes and via characterizing their IR and NMR elemental analysis sensitivity. Material and methods: These complexes combine octahedral ML6 and pyramidal ML5 tin complexes by allowing amino groups present in the medicinal ingredients to react with organotin (IV). Results: The complex conductivity was also determined for the prepared complexes and displayed low values. Discussions: Two concentrations of these complexes were screened for antibacterial activity against Gram+ve (Bacillus Pumilus) and (Candida albicans) by the Agar diffusion disc technique and showed a significant activity. In conclusion: the synthesized compounds proven to be more effective in inhibiting bacteria such as a) Bacillus Pumilus and b) Candida albicans at two concentrations (1×10-2, 1×10-4M).