Pituitary adenoma with gangliocytoma: A rare mixed tumor in the sellar region

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Journal of Clinical Sciences Pub Date : 2022-04-01 DOI:10.4103/jcls.jcls_26_22
A. Buch, N. Agarwal, Tushar Kambale, C. Gore
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Abstract

Sellar gangliocytomas are exceedingly rare, well-differentiated, low-grade neoplasms that frequently occur in the presence of a pituitary adenoma (PA). We report a case of a sellar gangliocytoma coexisting with growth hormone (GH) secreting PA. A 43-year-old man was brought to our hospital with right-eye visual disturbances for 2 months, along with headaches, acromegaly, temporal hemianopia in the right eye, and recent onset of Type 2 diabetes mellitus. Endocrinological studies found elevated serum level of GH. A computed tomographic scan showed a mass in the sellar region with suprasellar extension and thus a diagnosis of an expanding pituitary macroadenoma was established. It was removed by transnasal transsphenoidal surgery. On histopathological examination of the resected specimen, diagnosis of mixed gangliocytoma-PA was confirmed as it showed two distinct morphological components of the tumor comprising neoplastic ganglionic cells and adenomatous cells.
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垂体腺瘤合并神经节细胞瘤:一种罕见的鞍区混合性肿瘤
鞍区神经节细胞瘤是一种罕见的、分化良好的低级别肿瘤,常与垂体腺瘤合并发生。我们报告一个病例鞍状神经节细胞瘤共存生长激素(GH)分泌PA。患者43岁,男,右眼视力障碍2个月,伴有头痛、肢端肥大症、右眼颞部偏盲,近期发病2型糖尿病。内分泌学研究发现血清生长激素水平升高。计算机断层扫描显示鞍区肿块伴鞍上延伸,因此诊断为扩大的垂体大腺瘤。经鼻蝶窦手术切除。在切除标本的组织病理学检查中,证实了混合性神经节细胞瘤- pa的诊断,因为它显示了肿瘤的两种不同的形态成分,包括肿瘤神经节细胞和腺瘤细胞。
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来源期刊
Journal of Clinical Sciences
Journal of Clinical Sciences MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
15
审稿时长
45 weeks
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