Local mutations: on the tentative beginnings of molecular oncology in Britain 1980–2000

IF 1.3 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY New Genetics and Society Pub Date : 2021-01-02 DOI:10.1080/14636778.2021.1880887
S. Sturdy
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Abstract

Popular and scientific accounts of the molecularisation of cancer typically attribute it to advances in laboratory science, particularly molecular geneticists. However, historical research has indicated that clinical expertise input was often vital for advancing such work. The present paper reinforces that view. Looking in detail at British research into the molecular genetics of familial cancers during the 1980s and 1990s, it shows that that research, too, depended on crucial input from family cancer clinics. Moreover, the development of clinical services for familial cancers was in turn shaped by the demands of contributing to molecular genetic research. The paper concludes that accounts of the molecularisation of cancer that suppose a one-way transfer of knowledge and practice from laboratory to clinic misrepresent the complex interactions that were involved in molecularising familial cancers, and that were informed by the particular local and national circumstances in which they took shape.
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局部突变:1980-2000年英国分子肿瘤学的初步研究
大众和科学对癌症分子化的解释通常将其归因于实验室科学的进步,尤其是分子遗传学家。然而,历史研究表明,临床专业知识的投入往往是至关重要的推进这一工作。本文强化了这一观点。仔细观察上世纪80年代和90年代英国对家族性癌症分子遗传学的研究,结果表明,这些研究同样依赖于家族癌症诊所的关键投入。此外,家族性癌症临床服务的发展反过来又受到分子遗传学研究需求的影响。这篇论文的结论是,假设知识和实践从实验室到临床的单向转移,对癌症分子化的描述歪曲了家族性癌症分子化过程中涉及的复杂相互作用,这种相互作用是由特定的地方和国家环境形成的。
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来源期刊
New Genetics and Society
New Genetics and Society 生物-生物工程与应用微生物
CiteScore
4.30
自引率
16.70%
发文量
19
审稿时长
>12 weeks
期刊介绍: New Genetics and Society: Critical Studies of Contemporary Biosciences is a world-leading journal which: -Provides a focus for interdisciplinary and multi-disciplinary, leading-edge social science research on the new genetics and related biosciences; -Publishes theoretical and empirical contributions reflecting its multi-faceted development; -Provides an international platform for critical reflection and debate; -Is an invaluable research resource for the many related professions, including health, medicine and the law, wishing to keep abreast of fast changing developments in contemporary biosciences. New Genetics and Society publishes papers on the social aspects of the new genetics (widely defined), including gene editing, genomics, proteomics, epigenetics and systems biology; and the rapidly developing biosciences such as biomedical and reproductive therapies and technologies, xenotransplantation, stem cell research and neuroscience. Our focus is on developing a better understanding of the social, legal, ethical and policy aspects, including their local and global management and organisation.
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