A review: Determination of Diclofenac Sodium in Certain Pharmaceutical Preparations by Spectrophotometric and Chromatographic Methods

Abstract

Diclofenac is act as analgesic and antipyretic drug, known as voltarol, voltarine, dicloflex, and many other known brand names, formulated mainly as capsules and tablets, or as gel and suppositories. Spectrophotometric methods for determination of diclofenac were based on oxidation-reduction reaction or on complex -formation reactions, as well as determination based on UV - derivatives detection, first or second order. Many HPLC-methods for determination of DFC have been published, these methods use different dimensions C 18 columns and different compositions of mobile phases, acetonitrile is one of the major components of mobile phase because it offers a suitable polarity and viscosity, few procedures use the internal standard, while many of the selected review articles involve detection by UV-detector. Many other determination methods have been published, this review concern on the spectrophotometric and chromatographic methods. The aim of the review is to offer these reported methods to analysts to be in use for quality control of the dosage forms, and to use the selected procedures for new work to determine other related compounds.