Apoptosis’ activation associated to BH3 only domain and BCL-2 homology domain proteins: new way to design anti-cancer drugs

Abstract

Apoptosis or programmed cell dead is a genetically controlled mechanism that plays a crucial role in regulation and maintaining tissue homeostasis leading the elimination of old or damaged cells. Cancer is a disease that appears when a group of malignant or abnormal cells growth out of control dividing too quickly invading and destroying adjacent tissues forgetting how to die in the body. For these reasons, control the pathway of apoptosis could help to find or improve treatments for a lot of diseases, especially cancer. Decrease or increase in apoptosis, plays a key role in a great many diseases because unhealthy cells become immortal or on the contrary, healthy cells are indiscriminate killed, respectively.