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The anatomy of the thoracic spinal canal investigated with magnetic resonance imaging in children aged 0 to 13 years old 用磁共振成像研究0 ~ 13岁儿童胸椎椎管的解剖结构
Pub Date : 2023-02-15 DOI: 10.15406/jcpcr.2023.14.00512
Luiz Eduardo Imbelloni, Bruno Basilio Cardoso, Claudia Carrada Torres, Geraldo Borges de Morais Filho, Sylvio Valença de Lemos Neto, Ana Cristina Pinho
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引用次数: 0
Multifocal low-grade astrocytoma successfully treated with volumetric modulated arc therapy and concurrent temozolomide 多灶性低度星形细胞瘤经体积调节弧线疗法联合替莫唑胺治疗成功
Pub Date : 2021-12-27 DOI: 10.15406/jcpcr.2021.12.00475
E. Kamperis, D. Dionysopoulos, K. Efthymiadis, C. Kodona, T. Zarampoukas, K. Hatziioannou, V. Giannouzakos
Multifocal gliomas comprise an uncommon clinical entity with challenging diagnostic and therapeutic ramifications. In this article, we present the case of a young man with progressive memory loss that was found to have numerous space-occupying lesions masquerading as secondary metastases in his brain MRI. Histopathological examination revealed a diffuse low-grade astrocytoma. The patient was successfully treated with radical chemoradiotherapy and adjuvant temozolomide and has been recurrence-free during three years of regular follow-up. While we review the contemporary diagnostic and therapeutic options, we emphasize the necessity of stereotactic biopsy to 1. exclude brain metastases, 2. provide tissue for further molecular characterization, which is helpful for prognostication, and 3. guide an individualized treatment plan. We also contend against using whole-brain radiotherapy based on its well-recognized detrimental neurocognitive effects and its inability to allow dose escalation. Instead, targeted radiotherapy with IMRT/VMAT should be the preferred irradiation technique. As our imaging technology advances, so does our ability to diagnose multifocal lesions that would have been classified as unifocal in the past. Hence, we expect that we will, more often, be finding ourselves confronted with this clinical scenario in the future.
多灶性胶质瘤是一种罕见的临床实体,具有挑战性的诊断和治疗结果。在这篇文章中,我们报告了一个患有进行性记忆丧失的年轻男性的病例,在他的大脑MRI中发现有许多占位性病变伪装为继发性转移。组织病理学检查显示为弥漫性低度星形细胞瘤。患者成功接受了根治性放化疗和辅助替莫唑胺治疗,在三年的定期随访期间无复发。当我们回顾当代诊断和治疗的选择,我们强调立体定向活检的必要性1。排除脑转移,2。2 .为进一步的分子表征提供组织,这有助于预测;指导个体化治疗计划。我们也反对使用全脑放疗,因为它具有公认的有害神经认知效应,并且不能允许剂量增加。相反,IMRT/VMAT靶向放疗应该是首选的放疗技术。随着成像技术的进步,我们诊断多灶性病变的能力也在不断提高,而在过去,多灶性病变只能被归类为单灶性病变。因此,我们预计,我们将更经常地发现自己在未来面临这种临床情况。
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引用次数: 0
Diffuse hepatocellular carcinoma with extension into the right atrium 弥漫性肝细胞癌向右心房扩散
Pub Date : 2021-12-06 DOI: 10.15406/jcpcr.2021.12.00474
Jennifer Richardson, S. Serrano, Marco Luan
Hepatocellular carcinoma is one of the diagnoses that we most frequently see in our clinical practice, accustomed to seeing it as a single lesion, many do not know the diffuse subtype whose involvement and extension are rare. In this article, we present a case of diffuse hepatocarcinoma with cardiac extension and we discuss the importance of recognizing it because its management and prognosis depend on it.
肝细胞癌是我们在临床实践中最常见的诊断之一,习惯于将其视为单一病变,许多人不知道其累及和扩展罕见的弥漫性亚型。在本文中,我们报告一例弥漫性肝癌伴心脏扩展,并讨论认识它的重要性,因为它的治疗和预后取决于它。
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引用次数: 1
Towards better treatment outcomes for Australians with skin keratinocyte cancers - time for the patient voice? 为澳大利亚人的皮肤角质细胞癌提供更好的治疗结果-为患者发声的时间?
Pub Date : 2021-11-25 DOI: 10.15406/jcpcr.2021.12.00472
G. Fogarty, E. Paton, J. Allen, Julie Calvert, Tamara Dawson, Author Group of the Australian Keratinocyte Cancer Clinical Guidelines
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引用次数: 0
A fatal complication of colonoscopy due to a stenotic colon cancer: an alert to colleagues 狭窄性结肠癌致结肠镜检查的致命并发症:对同事的警告
Pub Date : 2021-10-22 DOI: 10.15406/jcpcr.2021.12.00471
Pedro G. Buiar, Marcela de Rezende Karnikowski
Colonoscopy is the most commonly performed method for Colon Cancer diagnosis and screening. And a successful exam requires bowel preparation. One of the main contraindications of the use of bowel cleansing agents is intestinal mechanical obstruction. But in many scenarios, as in public health services, there is a delay between the medical exam request and the data of the procedure. In some countries, this delay could be of many months. This interval is enough for nonobstructive colon cancer to turn into an obstructive lesion. The intake of bowel cleansing agents in an impending obstructive bowel syndrome could be a catastrophe. This is illustrated by this case report.
结肠镜检查是结肠癌诊断和筛查中最常用的方法。一个成功的检查需要肠道准备。使用肠道清洁剂的主要禁忌症之一是肠道机械性梗阻。但在许多情况下,如在公共卫生服务中,在医疗检查请求和程序数据之间存在延迟。在一些国家,这种延迟可能长达数月之久。这段时间足以使非梗阻性结肠癌转变为梗阻性病变。在即将发生的肠阻塞综合征中摄入肠道清洁剂可能是一场灾难。这个病例报告说明了这一点。
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引用次数: 0
Induction of tumor cell apoptosis in human glioblastoma cell lines by cationic peptides 阳离子多肽诱导人胶质母细胞瘤细胞系肿瘤细胞凋亡的研究
Pub Date : 2021-10-20 DOI: 10.15406/jcpcr.2021.12.00470
A. Lushnikova, A. V. Onyan, A. V. Kostarev, Ekaterina Yu. Rybalkina, Ksenia V Kohzikhova, S. Andreev
Background: Glioblastoma is very aggressive polymorphic brain tumor that is often chemo- and radio-resistant. This feature is related with glioma stem-like cells as well as with non-stem changeable cells from glioblastoma’s cell population. Search for molecular targets to overcome such resistance and to improve the effectiveness of therapy is one of the major challenges in applied molecular oncology. Objective: The aim of this study is to analyze a selective cytotoxicity of two cationic peptides (CPs) detected on two stable primary glioblastoma cell lines Glb0Sh and Glb-17. Induction of apoptosis in the cultures of recurrent glioblastoma cells and lack of cytotoxicity in normal cells was revealed by MTT assay, immunocytochemistry visualization of tumor cells after incubation with fluorescently labeled CP, RT PCR and western blotting. Results: We firstly confirm that chaperone proteins nucleolin/NCL and nucleophosmin/ NPM serve as cell molecular targets for CPs under study which has shown high selective cytotoxicity in two stable glioblastoma cell lines. These CPs are of interest for in vivo experiments as a promising anticancer agents.
背景:胶质母细胞瘤是一种侵袭性很强的多形性脑肿瘤,通常具有化疗和放射抵抗性。这一特征与胶质瘤干细胞样细胞以及来自胶质瘤细胞群的非干细胞变性细胞有关。寻找分子靶点来克服这种耐药性并提高治疗的有效性是应用分子肿瘤学的主要挑战之一。目的:分析两种阳离子肽(CPs)对两种稳定的原发性胶质母细胞瘤细胞系Glb0Sh和Glb-17的选择性细胞毒性。MTT法、荧光标记CP、RT - PCR和western blotting培养后肿瘤细胞的免疫细胞化学可视化显示,发现复发性胶质母细胞瘤细胞诱导凋亡,正常细胞无细胞毒性。结果:我们首次证实了伴侣蛋白nucleolin/NCL和nucleophosmin/ NPM是正在研究的CPs的细胞分子靶点,在两种稳定的胶质母细胞瘤细胞系中显示出高选择性的细胞毒性。这些CPs作为一种有前景的抗癌药物,在体内实验中具有重要意义。
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引用次数: 0
Non-mucinous adenocarcinoma: a unique case with a deceptive presentation 非黏液性腺癌:一个具有欺骗性表现的独特病例
Pub Date : 2021-09-28 DOI: 10.15406/jcpcr.2021.12.00469
Jason Pannozzo, S. Vyas, G. Letterio, Harold A Matos-Casano, U. Bhatt, W. Cruz-Vetrano
Non-mucinous lepidic adenocarcinoma with pneumonic presentation is a rare form of lung cancer. Its ability to mimic infectious and inflammatory diseases in both patient presentation and diagnostic imaging can result in a delayed diagnosis. This case follows the workup of a 60-year-old non-smoker female who immigrated from Ecuador twenty years prior and worked at a shore repair shop for the past two years who presented with worsening shortness of breath and 15lbs weight loss over a two-month period. A unique aspect of this patient’s presentation was that the typical imaging and bronchoscopy findings often seen to distinguish this type of lung adenocarcinoma from other disease processes were absent. No nodular masses were observed on Computed Tomography (CT), and no lesions or airway abnormalities were seen on bronchoscopy. It was not until biopsy and bronchoalveolar lavage (BAL) that the diagnosis of adenocarcinoma was recognized. Our case aims to increase awareness among clinicians of the unpredictable presentation of nonmucinous lepidic adenocarcinoma. Furthermore, we want to highlight the relevance of including adenocarcinoma of the lung in the differential diagnosis even when infectious or occupational etiologies appear more likely.
以肺为表现的非黏液性肺腺癌是一种罕见的肺癌。它在患者表现和诊断成像方面模仿感染性和炎症性疾病的能力可能导致诊断延迟。本病例是在对一名60岁的非吸烟女性进行检查后发现的,她20年前从厄瓜多尔移民过来,过去两年在一家海岸维修店工作,她出现呼吸急促加重,体重在两个月内减轻了15磅。该患者表现的一个独特方面是,通常用来区分这种类型的肺腺癌与其他疾病过程的典型影像学和支气管镜检查结果缺失。CT检查未见结节性肿块,支气管镜检查未见病变或气道异常。直到活检和支气管肺泡灌洗(BAL)才确认腺癌的诊断。我们的病例旨在提高临床医生对不可预测的非粘液性卵泡腺癌的认识。此外,我们想强调在鉴别诊断中包括肺腺癌的相关性,即使感染性或职业性病因出现的可能性更大。
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引用次数: 0
Mucormycosis: An ignorance that cannot be ignored 毛霉病:不能忽视的无知
Pub Date : 2021-08-30 DOI: 10.15406/jcpcr.2021.12.00468
Anuhya Reddy M
Mucormycosis (formerly known as zygomycosis) is a severe but uncommon fungal disease characterized by a clan of moulds known as mucormycetes. These moulds may be found all over the place. Mucormycosis primarily affects those who have chronic illnesses or who use medications that decrease the body’s potential to exacerbate infections and infirmity. When individuals inhale fungal spores from the air, it most frequently affects the sinuses or lungs. Steroid usage, diabetes, and improper use of oxygen administration are all risk factors. This infection is characterized by headache, facial pain, nasal congestion, loss of vision or pain in the eyes, swelling in cheeks and eyes, black crests in the nose, coughing, and bloody vomits. Death occurs as a consequence of a lack of awareness of symptoms of Mucormycosis, high cost of therapy and the scarcity of medications, ignoring check-ups, and self-medication. Treatment of this devastating disease includes surgical excision of the involved part followed by antifungal therapy. While the rise of Mucormycosis in Covid instances is concerning, it is time for experts to work together to stop the spread of Mucormycosis. A solid referral and communication system among health professionals (e.g., pulmonologist, ENT surgeon, general physician, and maxillofacial dental surgeon) is the most important step in combating the disease in the current situation.
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引用次数: 0
Spirituality in addressing death in oncological patients in palliative care 在姑息治疗中解决肿瘤患者死亡的灵性问题
Pub Date : 2021-08-19 DOI: 10.15406/jcpcr.2021.12.00467
Manoel Pereira da Silva Junior, Michelly de Oliveira Leopoldino, Fernanda Silva Monteiro, Ana Paula Miyazawa
For the oncology patient in palliative care, talking about the process of death and dying can cause discomfort, because, in addition to insecurity about their future, it can awaken a negative feeling that influences the way the patient and his family deal with the situation imposed by illness. The aim of this study was to discuss the role of spirituality in coping with death in patients under palliative care. This is a descriptive, exploratory study with a qualitative approach carried out through a literature review. A search was carried out in the sources of concepts and principles: National Palliative Care Agency-ANCP and the National Cancer Institute-INCA, as well as research in Scientifc Eletronic Library Online (Scielo), in the databases, in the virtual health library (VHL) ) and Latin American in Health Sciences (LILACS) in the period from July to November 2019. One can experience spirituality even though conceptualizing it as atheism, as the search for spirituality does not necessarily mean a search for God. This demonstrates how spirituality has a particular and subjective character, without having to follow absolute truths imposed by religions. Ignoring the spiritual dimension makes the patient’s approach incomplete because it puts the focus of care centered on the disease. It is concluded that the humanization of palliative care for cancer patients must go further, contemplating the patient’s spiritual issues, since the concern and questions about death take on a greater proportion when physical symptoms are no longer a challenge to be addressed. overcome, but rather, the fear of the unknown before the prospect of death.
对于接受姑息治疗的肿瘤患者来说,谈论死亡和临终的过程可能会引起不适,因为除了对他们未来的不安全感之外,它还会唤醒一种消极的感觉,影响患者及其家人处理疾病所带来的情况的方式。本研究的目的是讨论精神在姑息治疗患者应对死亡中的作用。这是一项描述性的探索性研究,通过文献综述采用定性方法进行。对概念和原则的来源进行了检索:国家姑息治疗机构(ancp)和国家癌症研究所(inca),以及科学电子图书馆在线(Scielo)、数据库、虚拟健康图书馆(VHL)和拉丁美洲健康科学(LILACS)在2019年7月至11月期间的研究。即使将其概念化为无神论,一个人也可以体验到灵性,因为寻求灵性并不一定意味着寻找上帝。这证明了灵性是如何具有特定的和主观的特征,而不必遵循宗教强加的绝对真理。忽视精神层面使病人的治疗方法不完整,因为它把护理的重点放在疾病上。结论是,癌症患者姑息治疗的人性化必须更进一步,考虑患者的精神问题,因为当身体症状不再是需要解决的挑战时,对死亡的关注和问题所占的比例更大。而是在面对死亡之前克服对未知的恐惧。
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引用次数: 0
Case of inherited epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC) in a 37-year-old male  37岁男性非小细胞肺癌(NSCLC)中遗传性表皮生长因子受体(EGFR) 1例
Pub Date : 2021-08-13 DOI: 10.15406/jcpcr.2021.12.00466
Joseph R. Malhis, S. O'Brien, R. Vasanwala, Kerry J Williams-Wuch
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引用次数: 0
期刊
Journal of Cancer Prevention & Current Research
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