{"title":"Synthesis and Anti Convulsant Activity of Novel Oxadiazole Substituted Phenothiazine Derivatives","authors":"Dighe Ns, Bankar Aa, DS Musmade, S. Nirmal","doi":"10.9734/BPI/CACB/V4/1783F","DOIUrl":null,"url":null,"abstract":"The research is directed towards the synthesis and evaluation of novel agents for the treatment of various neurological disorders. The phenothiazine nucleus has been well explored for the various biological activities in past. The oxadiazole substituted phenothiazine have been of keen interest as a drug candidate for the treatment of various neurological disorders. In view of these an attempt has been made to synthesize substituted phenothiazine and explore them for promising anti convulsant activity. The anti-convulsant activity of synthesized compounds had been done by using Strychnine induced and 4-amino pyridine induced models.","PeriodicalId":19541,"journal":{"name":"Organic Chemistry: An Indian Journal","volume":"140 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry: An Indian Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/BPI/CACB/V4/1783F","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The research is directed towards the synthesis and evaluation of novel agents for the treatment of various neurological disorders. The phenothiazine nucleus has been well explored for the various biological activities in past. The oxadiazole substituted phenothiazine have been of keen interest as a drug candidate for the treatment of various neurological disorders. In view of these an attempt has been made to synthesize substituted phenothiazine and explore them for promising anti convulsant activity. The anti-convulsant activity of synthesized compounds had been done by using Strychnine induced and 4-amino pyridine induced models.
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