OBTAINING A HYDROGEL BASED ON CHITOSAN, STUDY ITS STRUCTURE AND SORBTION ABILITY WITH LEVOFLOXACIN ANTIBIOTICS

Abstract

Network polymer hydrogels with high swelling effect were synthesized by using of ultraviolet crosslinking, with crosslinking agent N,N'-methylene-bis-acrylamide with chitosan an average molecular weight of 100-300 kDa t. The amount of crosslinking agent made up 10% of chitosan weight. The gel structure was studied using FTIR and the mechanism of the cross-linking process identified. The sorption of levofloxacin on the obtained hydrogel was studied at different pH and the degree of sorption and the dependence of the sorption capacity of the hydrogel on the pH of the medium was studied. It found that the degree of sorption of hydrogel by levofloxacin is 90.4 % while the sorption capacity of gel increases as pH of the medium rises and at pH=8 it has the highest value equal to 8.9 mg/g.