{"title":"Stop smoking, keep walking, . . . and other stories","authors":"","doi":"10.1136/bmj.p1993","DOIUrl":null,"url":null,"abstract":"The human genome encodes approximately 20 000 proteins. Understandably enough, investigations have concentrated on genes and proteins whose function is known.However, thehuman “unknome,” the one fifth of humangeneswhosepurpose remains mysterious, shouldn’t be ignored. Many of these genes are conserved across species. In experiments with fruit flies, removing one of these mystery genes caused the insects to die. The compilers of a new database of genes with unknown functions hope it will widen the focus of genetic research (PLoS Biol doi:10.1371/journal.pbio.3002222).","PeriodicalId":72433,"journal":{"name":"BMJ medicine","volume":"25 1","pages":""},"PeriodicalIF":10.0000,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/bmj.p1993","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The human genome encodes approximately 20 000 proteins. Understandably enough, investigations have concentrated on genes and proteins whose function is known.However, thehuman “unknome,” the one fifth of humangeneswhosepurpose remains mysterious, shouldn’t be ignored. Many of these genes are conserved across species. In experiments with fruit flies, removing one of these mystery genes caused the insects to die. The compilers of a new database of genes with unknown functions hope it will widen the focus of genetic research (PLoS Biol doi:10.1371/journal.pbio.3002222).
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