The clinical importance of emerging ESKAPE pathogens in nosocomial infections

Abstract

In the last decade, along with the problem of nosocomial infections, multidrug-resistant bacteria in community and hospitals have soared. High frequencies of multidrug-resistant bacteria have been grouped under the acronym ESKAPE: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. The ESKAPE pathogens are responsible for the majority of nosocomial infections and capable of 'escaping' the biocidal action of antimicrobial agents. The objective of this review is to consider the clinical importance of emerging of ESKAPE pathogens in nosocomial infections to prepare feasible data about tracing and treatment of infection related to ESKAPE pathogens that may be beneficial to clinicians at the bedhead. It can be said that healthcare-associated, community-acquired, and nosocomial infections should be clearly considered annually. The awareness of residential antimicrobial resistance can support selecting a convenient empirical therapeutic diet in diseases due to ESKAPE pathogens.