Pub Date : 2019-04-15DOI: 10.22037/JPS.V10I2.16082
F. Abdi, Z. Moghadam, M. Yazdkhasti, Tayebeh Darooneh, S. Rostami
Context: Thrombophilia is an inherited or acquired predisposition in developing thrombosis. The two common thrombophilia polymorphisms are factor V Leiden (FVL) and factor II/ prothrombin G20210A (PT) gene mutations which can contribute to negative pregnancy outcomes such as miscarriage, in-vitro fertilization (IVF) failure, preeclampsia, intrauterine growth restriction (IUGR), placental abruption, stillbirth, and pregnancy-associated venous thromboembolism. This review study sought to describe the effects of FVL and PT mutations on pregnancy complications. Evidence Acquisition: In this review study, a comprehensive search was performed on Iranian and international databases including MEDLINE, PubMed, Scopus, Web of Sciences, Proquest and Google Scholar for articles published during 1996-2018. Out of 220 reviewed articles, 80 papers were ultimately selected. Results: According to these 80 selected papers, the possible relations of PT and FVL with recurrent pregnancy loss (RPL) have been widely evaluated. Several studies indicated higher risk of recurrent early miscarriages, implantation failure and fetal loss after IVF among women with FVL and PT mutations. Conclusion: Observational studies have suggested the benefits of screening patients for thrombophilic polymorphisms in identification of women with higher risk of developing thromboembolic events and other related pregnancy complications. Based on such screening programs, prophylactic therapy can be limited to a selected group of women who truly need it.
背景:血栓形成是一种遗传或获得性的血栓形成倾向。两种常见的血栓形成多态性是因子V Leiden (FVL)和因子II/凝血酶原G20210A (PT)基因突变,可导致不良妊娠结局,如流产、体外受精(IVF)失败、先兆子痫、宫内生长受限(IUGR)、胎盘早拆、死胎和妊娠相关静脉血栓栓塞。本综述旨在描述FVL和PT突变对妊娠并发症的影响。证据获取:在本综述研究中,对伊朗和国际数据库进行了全面搜索,包括MEDLINE、PubMed、Scopus、Web of Sciences、Proquest和Google Scholar,检索1996-2018年期间发表的文章。在220篇被审查的文章中,有80篇最终被选中。结果:通过这80篇入选的论文,广泛评价了PT和FVL与复发性妊娠丢失(RPL)的可能关系。一些研究表明,在FVL和PT突变的妇女中,IVF后复发性早期流产、植入失败和胎儿丢失的风险更高。结论:观察性研究表明,筛查患者的血栓性多态性在鉴别发生血栓栓塞事件和其他相关妊娠并发症的高风险妇女方面是有益的。基于这样的筛查项目,预防性治疗可以局限于一组真正需要的妇女。
{"title":"The Putative Role of Factor V Leiden and Prothrombin Mutations in Pregnancy Complications","authors":"F. Abdi, Z. Moghadam, M. Yazdkhasti, Tayebeh Darooneh, S. Rostami","doi":"10.22037/JPS.V10I2.16082","DOIUrl":"https://doi.org/10.22037/JPS.V10I2.16082","url":null,"abstract":"Context: Thrombophilia is an inherited or acquired predisposition in developing thrombosis. The two common thrombophilia polymorphisms are factor V Leiden (FVL) and factor II/ prothrombin G20210A (PT) gene mutations which can contribute to negative pregnancy outcomes such as miscarriage, in-vitro fertilization (IVF) failure, preeclampsia, intrauterine growth restriction (IUGR), placental abruption, stillbirth, and pregnancy-associated venous thromboembolism. This review study sought to describe the effects of FVL and PT mutations on pregnancy complications. Evidence Acquisition: In this review study, a comprehensive search was performed on Iranian and international databases including MEDLINE, PubMed, Scopus, Web of Sciences, Proquest and Google Scholar for articles published during 1996-2018. Out of 220 reviewed articles, 80 papers were ultimately selected. Results: According to these 80 selected papers, the possible relations of PT and FVL with recurrent pregnancy loss (RPL) have been widely evaluated. Several studies indicated higher risk of recurrent early miscarriages, implantation failure and fetal loss after IVF among women with FVL and PT mutations. Conclusion: Observational studies have suggested the benefits of screening patients for thrombophilic polymorphisms in identification of women with higher risk of developing thromboembolic events and other related pregnancy complications. Based on such screening programs, prophylactic therapy can be limited to a selected group of women who truly need it.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"41 1","pages":"63-77"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83656717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-18DOI: 10.22037/JPS.V10I1.22821
Shirin Tarahomjoo, S. Tabatabaei, A. Karimi, M. Rahbar
Introduction: Capsular polysaccharides of pneumococci are principle antigenic constituents of vaccines against pneumococci. Enhancing the yield of capsule production decreases costs of these vaccines and increases the vaccine coverage in developing countries. In this study therefore, we aim to optimize the capsule production from serotype 19F pneumococcus in terms of the applied pneumococcal strain and environmental culture conditions. Materials and Methods: Thirteen serotype 19F Streptococcus pneumoniae strains were screened for the capsule production in modified Hoeprich culture medium using the stains all assay. The optimal ranges of environmental culture conditions for the selected strain were determined using single factor at a time (SFAT) strategy and utilized for the design of experiments based on the response surface methodology (RSM). Results: S. pneumoniae 82218 showed the highest capsule production, and thus used for further studies. The maximum capsule production (1.364 mg/ml) was attained under optimal conditions (pH 7.26, 35.5 oC, 30 rpm) predicted by the RSM derived quadratic model. The capsule production under the optimal conditions increased to 1.9 mg/ml using the buffered culture medium. Conclusion : These results are much higher than those reported for pneumococcal capsule production in published studies [ 1 , 2 ] and thus can be used to design suitable systems for the serotype 19F capsule production in the vaccine manufacturing process. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;}
{"title":"Strain Selection and Statistical Optimization of Culture Conditions for 19F Polysaccharide Production from Pneumococcus","authors":"Shirin Tarahomjoo, S. Tabatabaei, A. Karimi, M. Rahbar","doi":"10.22037/JPS.V10I1.22821","DOIUrl":"https://doi.org/10.22037/JPS.V10I1.22821","url":null,"abstract":"Introduction: Capsular polysaccharides of pneumococci are principle antigenic constituents of vaccines against pneumococci. Enhancing the yield of capsule production decreases costs of these vaccines and increases the vaccine coverage in developing countries. In this study therefore, we aim to optimize the capsule production from serotype 19F pneumococcus in terms of the applied pneumococcal strain and environmental culture conditions. Materials and Methods: Thirteen serotype 19F Streptococcus pneumoniae strains were screened for the capsule production in modified Hoeprich culture medium using the stains all assay. The optimal ranges of environmental culture conditions for the selected strain were determined using single factor at a time (SFAT) strategy and utilized for the design of experiments based on the response surface methodology (RSM). Results: S. pneumoniae 82218 showed the highest capsule production, and thus used for further studies. The maximum capsule production (1.364 mg/ml) was attained under optimal conditions (pH 7.26, 35.5 oC, 30 rpm) predicted by the RSM derived quadratic model. The capsule production under the optimal conditions increased to 1.9 mg/ml using the buffered culture medium. Conclusion : These results are much higher than those reported for pneumococcal capsule production in published studies [ 1 , 2 ] and thus can be used to design suitable systems for the serotype 19F capsule production in the vaccine manufacturing process. /* Style Definitions */ \u0000 table.MsoNormalTable \u0000 {mso-style-name:\"Table Normal\"; \u0000 mso-tstyle-rowband-size:0; \u0000 mso-tstyle-colband-size:0; \u0000 mso-style-noshow:yes; \u0000 mso-style-priority:99; \u0000 mso-style-qformat:yes; \u0000 mso-style-parent:\"\"; \u0000 mso-padding-alt:0in 5.4pt 0in 5.4pt; \u0000 mso-para-margin:0in; \u0000 mso-para-margin-bottom:.0001pt; \u0000 mso-pagination:widow-orphan; \u0000 font-size:11.0pt; \u0000 font-family:\"Calibri\",\"sans-serif\"; \u0000 mso-ascii-font-family:Calibri; \u0000 mso-ascii-theme-font:minor-latin; \u0000 mso-fareast-font-family:\"Times New Roman\"; \u0000 mso-fareast-theme-font:minor-fareast; \u0000 mso-hansi-font-family:Calibri; \u0000 mso-hansi-theme-font:minor-latin; \u0000 mso-bidi-font-family:Arial; \u0000 mso-bidi-theme-font:minor-bidi;}","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"12 1","pages":"34-46"},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76162891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-18DOI: 10.22037/JPS.V10I1.23593
V. Alipour, R. Shabani, M. Zarrindast, F. Rahmani-nia, M. Nasehi
Introduction: Recent researchers have showed that regular exercise induces positive effects on cognitive functions. Exercise intensity and timing of cognitive assessment may have an interactive effect on cognitive changes. Previous researches suggest that moderate intensity treadmill running has the most consistent benefit to cognitive function. In contrast, studies find positive, negative, or null effects to cognitive function after high intensity treadmill running. The primary objective of the present study was to compare the cognitive effects of intensity treadmill running protocol 1 (Low intensity), protocol 2 (Moderate intensity) and protocol 1 plus 2 (High intensity). Materials and Methods: Male Wistar rats were divided into four groups (n=7 in each group) including: sedentary (Non-exercise), protocol 1, protocol 2, and combination of protocol 1 and 2. Step-through passive avoidance and elevated-plus maze apparatus have been used to test parameters of passive avoidance learning and anxiety-like behaviors. Results: These findings showed that combination of both protocols (Protocol 1 with protocol 2) decreased step-through latency in the passive avoidance apparatus indicating memory impairment [P 0.05] and locomotor activity %OAT [P<0.05] compared to control group but not others. Conclusion: High intensity exercise not only induced beneficial effect but also impaired memory formation.
{"title":"Influence of Moderate and Severe Exercise on Memory Formation and Anxiety-like Behaviors in Male Wistar Rat","authors":"V. Alipour, R. Shabani, M. Zarrindast, F. Rahmani-nia, M. Nasehi","doi":"10.22037/JPS.V10I1.23593","DOIUrl":"https://doi.org/10.22037/JPS.V10I1.23593","url":null,"abstract":"Introduction: Recent researchers have showed that regular exercise induces positive effects on cognitive functions. Exercise intensity and timing of cognitive assessment may have an interactive effect on cognitive changes. Previous researches suggest that moderate intensity treadmill running has the most consistent benefit to cognitive function. In contrast, studies find positive, negative, or null effects to cognitive function after high intensity treadmill running. The primary objective of the present study was to compare the cognitive effects of intensity treadmill running protocol 1 (Low intensity), protocol 2 (Moderate intensity) and protocol 1 plus 2 (High intensity). Materials and Methods: Male Wistar rats were divided into four groups (n=7 in each group) including: sedentary (Non-exercise), protocol 1, protocol 2, and combination of protocol 1 and 2. Step-through passive avoidance and elevated-plus maze apparatus have been used to test parameters of passive avoidance learning and anxiety-like behaviors. Results: These findings showed that combination of both protocols (Protocol 1 with protocol 2) decreased step-through latency in the passive avoidance apparatus indicating memory impairment [P 0.05] and locomotor activity %OAT [P<0.05] compared to control group but not others. Conclusion: High intensity exercise not only induced beneficial effect but also impaired memory formation.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"51 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82744853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-18DOI: 10.22037/JPS.V10I1.23597
F. Asadi, F. Rouzbahani, R. Rabiei, H. Moghaddasi, H. Emami
Context: The healthcare in different countries faces challenges in enhancing the quality of services and reducing the costs. Information governance provides a tool for effective and efficient management of information, the use of which contributes to improved productivity, and effectiveness of services and reduced costs. Identifying the applications and benefits of using this tool paves the way for its accurate and effective deployment in a variety of healthcare organizations. This study was conducted to identify and classify the applications of information governance program within healthcare systems. Evidence Acquisition: The study reviewed English studies related to the information governance applications in healthcare published during 2000 and 2017. The publications were identified by searching the Pub Med, Google Scholar, ProQuest, Scopus and Science Direct databases. The key words included, but not restricted to, information governance, health information governance, information governance program and impacts of information governance in health care. Having completed the search, 128 studies were retrieved, of which 23 were reviewed. Results: The Information Governance program applications were categorized into five general groups, including improving healthcare and patient safety, reducing the costs, enhancing the quality of data and information healthcare, enhancing the security and confidentiality of patient information, improving the management of information and healthcare organizations. Conclusion: Through developing and implementing of Health Information Governance programs, updating information and upgrading information technologies, healthcare organizations could improve the quality of healthcare services and reduce the subsequent costs to achieve competitive advantages.
{"title":"Information Governance Program: A Review of Applications in Healthcare","authors":"F. Asadi, F. Rouzbahani, R. Rabiei, H. Moghaddasi, H. Emami","doi":"10.22037/JPS.V10I1.23597","DOIUrl":"https://doi.org/10.22037/JPS.V10I1.23597","url":null,"abstract":"Context: The healthcare in different countries faces challenges in enhancing the quality of services and reducing the costs. Information governance provides a tool for effective and efficient management of information, the use of which contributes to improved productivity, and effectiveness of services and reduced costs. Identifying the applications and benefits of using this tool paves the way for its accurate and effective deployment in a variety of healthcare organizations. This study was conducted to identify and classify the applications of information governance program within healthcare systems. Evidence Acquisition: The study reviewed English studies related to the information governance applications in healthcare published during 2000 and 2017. The publications were identified by searching the Pub Med, Google Scholar, ProQuest, Scopus and Science Direct databases. The key words included, but not restricted to, information governance, health information governance, information governance program and impacts of information governance in health care. Having completed the search, 128 studies were retrieved, of which 23 were reviewed. Results: The Information Governance program applications were categorized into five general groups, including improving healthcare and patient safety, reducing the costs, enhancing the quality of data and information healthcare, enhancing the security and confidentiality of patient information, improving the management of information and healthcare organizations. Conclusion: Through developing and implementing of Health Information Governance programs, updating information and upgrading information technologies, healthcare organizations could improve the quality of healthcare services and reduce the subsequent costs to achieve competitive advantages.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"136 1","pages":"47-55"},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75778463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-12DOI: 10.22037/JPS.V10I1.24111
M. Heydarpour, Mojgan Rashtchi, A. Mohseni
Introduction: The current study sought to investigate the impact of text modifications (lexically and grammatically modified) on reading comprehension ability of medical students with high and low levels of anxiety. Materials and Methods: To pursue the purpose of this study, 150 male and female medical students from Shahid Beheshti University of Medical Sciences participated in the study. The participants did not take a language proficiency test to ensure homogeneity, as pretesting might affect the internal and external validity of the study due to the interaction effect of pretesting [1]. The framework proposed by [2]. Moreover, a questionnaire developed by [3] entitled “Foreign Language Reading Anxiety Scale (FLRAS)” on a five-point Likert scale with 20 items served as an instrument. MANOVA was run to analyze the data. Results: The findings revealed that there was a significant difference between the reading comprehension ability of medical students with high and low levels of anxiety exposed to lexically modified (p<0.01), grammatically modified (p<0.01), lexically and grammatically modified (p<0.01), and unmodified passages (p<0.01). Conclusion: It is hoped that the findings from this study will guide researchers into new directions so that they may go on to discover profound insights about text simplification for medical students in Iran and all over the world.
{"title":"Anxiety Effect: A Case of Text Modification and the Effect of High and Low Anxiety Levels on Medical Students’ Comprehension Performance","authors":"M. Heydarpour, Mojgan Rashtchi, A. Mohseni","doi":"10.22037/JPS.V10I1.24111","DOIUrl":"https://doi.org/10.22037/JPS.V10I1.24111","url":null,"abstract":"Introduction: The current study sought to investigate the impact of text modifications (lexically and grammatically modified) on reading comprehension ability of medical students with high and low levels of anxiety. Materials and Methods: To pursue the purpose of this study, 150 male and female medical students from Shahid Beheshti University of Medical Sciences participated in the study. The participants did not take a language proficiency test to ensure homogeneity, as pretesting might affect the internal and external validity of the study due to the interaction effect of pretesting [1]. The framework proposed by [2]. Moreover, a questionnaire developed by [3] entitled “Foreign Language Reading Anxiety Scale (FLRAS)” on a five-point Likert scale with 20 items served as an instrument. MANOVA was run to analyze the data. Results: The findings revealed that there was a significant difference between the reading comprehension ability of medical students with high and low levels of anxiety exposed to lexically modified (p<0.01), grammatically modified (p<0.01), lexically and grammatically modified (p<0.01), and unmodified passages (p<0.01). Conclusion: It is hoped that the findings from this study will guide researchers into new directions so that they may go on to discover profound insights about text simplification for medical students in Iran and all over the world.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"6 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2019-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74659914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-12DOI: 10.22037/jps.v10i1.16352
S. Momenyan, H. Majd
Introduction : Crossover designs have applications in a wide range of sciences. The simplest and most common of such designs are the two-period, two-treatment (2×2) crossover. As a consequence, each subject provides a 4×1 vector of responses for data analysis in the following chronological order: baseline (period 1), post-baseline (period 1), baseline (period 2), and post-baseline (period 2). Methods : We considered three types of analytic approaches for handling the baselines:1) analysis of variance (ANOVA) method which ignores the first or both period baselines or use a change from baseline analysis 2) analysis of covariance (ANCOVA) method which uses an analysis of covariance where linear functions of one or both baselines are employed as either period-specific or period-invariant covariates 3) Joint modeling method that conducts joint modeling of a linear function of the baseline and post-baseline responses with certain mean constraints for the baseline responses. The crossover clinical trial data was analyzed, using the proposed models. Results : Based on the results on real data among all mentioned models, the first model (direct comparison of post-treatment values) and the second model (post-treatment measurement subtracts corresponding baseline) had the lowest and the highest standard errors, respectively. With respect to Akaike Information Criterion (AIC), the fifth model (comparison of post-treatment values adjusted by all available baseline data) and the eighth model (comparison of post-treatment values adjusted by difference and sum of all available baseline data) had the lowest magnitude, and the ninth model (modeling period baseline jointly with post-treatment values) had the highest AIC for both variables which the values of AIC were 518.1, 520.9 and 1137.8, respectively. Conclusion: To sum up, it is found that baseline data of crossover trial may be used to improve the efficiency of treatment effect estimation when applied appropriately.
简介:交叉设计在许多科学领域都有广泛的应用。这种设计中最简单和最常见的是两周期,两处理(2×2)交叉。因此,每个受试者按照以下时间顺序为数据分析提供了4×1响应向量:基线(第1期)、基线后(第1期)、基线后(第2期)和基线后(第2期)。我们考虑了三种处理基线的分析方法:1)方差分析(ANOVA)方法,它忽略了第一个或两个时期的基线,或使用基线变化分析;2)协方差分析(ANCOVA)方法,它使用协方差分析,其中一个或两个基线的线性函数被用作特定时期或周期不变的协变量;3)联合建模方法,对基线的线性函数进行联合建模基线后反应,对基线反应有一定的平均约束。使用提出的模型对交叉临床试验数据进行分析。结果:从实际数据的结果来看,第一种模型(直接比较处理后的值)和第二种模型(处理后的测量减去相应的基线)的标准误差最小,最高。在赤池信息准则(Akaike Information Criterion, AIC)方面,第5个模型(经所有可用基线数据调整后的处理后值的比较)和第8个模型(经所有可用基线数据的差值和调整后值的比较)的幅度最小,第9个模型(建模期基线与处理后值联合)的AIC值最高,分别为518.1、520.9和1137.8。结论:综上所述,交叉试验的基线数据如果应用得当,可以提高治疗效果估计的效率。
{"title":"Management of Baseline Measurements in Statistical Analysis of 2×2 Crossover Trials","authors":"S. Momenyan, H. Majd","doi":"10.22037/jps.v10i1.16352","DOIUrl":"https://doi.org/10.22037/jps.v10i1.16352","url":null,"abstract":"Introduction : Crossover designs have applications in a wide range of sciences. The simplest and most common of such designs are the two-period, two-treatment (2×2) crossover. As a consequence, each subject provides a 4×1 vector of responses for data analysis in the following chronological order: baseline (period 1), post-baseline (period 1), baseline (period 2), and post-baseline (period 2). Methods : We considered three types of analytic approaches for handling the baselines:1) analysis of variance (ANOVA) method which ignores the first or both period baselines or use a change from baseline analysis 2) analysis of covariance (ANCOVA) method which uses an analysis of covariance where linear functions of one or both baselines are employed as either period-specific or period-invariant covariates 3) Joint modeling method that conducts joint modeling of a linear function of the baseline and post-baseline responses with certain mean constraints for the baseline responses. The crossover clinical trial data was analyzed, using the proposed models. Results : Based on the results on real data among all mentioned models, the first model (direct comparison of post-treatment values) and the second model (post-treatment measurement subtracts corresponding baseline) had the lowest and the highest standard errors, respectively. With respect to Akaike Information Criterion (AIC), the fifth model (comparison of post-treatment values adjusted by all available baseline data) and the eighth model (comparison of post-treatment values adjusted by difference and sum of all available baseline data) had the lowest magnitude, and the ninth model (modeling period baseline jointly with post-treatment values) had the highest AIC for both variables which the values of AIC were 518.1, 520.9 and 1137.8, respectively. Conclusion: To sum up, it is found that baseline data of crossover trial may be used to improve the efficiency of treatment effect estimation when applied appropriately.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"33 1","pages":"13-19"},"PeriodicalIF":0.0,"publicationDate":"2019-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73493349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-30DOI: 10.22037/jps.v10i1.19886
A. Heidari, E. Kalantar, M. Dehghan, P. Fallah
Introduction: One of the most common causes of encephalitis is due to viral infections, such as herpes simplex. Traditionally, brain biopsy was required for the diagnosis of HSV encephalitis; however, here CSF PCR detection for herpes simplex encephalitis is reported which was successfully treated with Acyclovir. Case presentation: A 52 year old female patient was brought to emergency department with fever (40 0 C), constipation, abdominal pain, fatigue, disorientation and agitation for the last two days. DNA extraction and Real Time PCR was performed on CSF sample for HSV-1/2 and HSV-1 was positive. Moreover, the brain MRI report showed left and basal temporal oppression, together with left and basal frontal pus. The patient was discharged after 20 days of hospitalization and treatment with acyclovir and normal physiological indexes and had a good clinical and neurologic outcome with resolution of all the symptoms. Conclusion: It is worthy to emphasize that despite the normal biochemical CSF, imaging results and PCR are proved evidence of HSV encephalitis.
脑炎最常见的原因之一是由于病毒感染,如单纯疱疹。传统上,诊断HSV脑炎需要脑活检;然而,这里的脑脊液PCR检测单纯性疱疹脑炎是成功地用阿昔洛韦治疗。病例介绍:一名52岁女性患者因发热(40℃)、便秘、腹痛、疲劳、定向障碍和躁动2天被送至急诊科。对脑脊液样本进行DNA提取和Real Time PCR检测,HSV-1阳性。此外,脑MRI报告显示左侧和基底颞压迫,以及左侧和基底额脓液。患者住院20天后,经阿昔洛韦治疗,各项生理指标正常,临床及神经系统预后良好,症状全部缓解,出院。结论:值得强调的是,尽管脑脊液生化正常,但影像学和PCR结果均为HSV脑炎的证据。
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Recently, Abbasiyan et al . published an interesting paper entitled “Do the Editors-in-Chief of Iranian Medical Journals have a Good Knowledge, Attitude and Practice of Plagiarism?” , addressing the ethical disputes occurred in last years in the Iranian research atmosphere [1]. In this study, authors nicely discussed the recent reports and flagged a critical suggestion for research decision-makers in Iran. Enjoo published a letter indicating on urgent need to have a new organization for having better situation [2]. Meantime, I think that newer policy help this idea before it can be widely referred. At first glance, there is an agreement that the current ethical administrative structure conducted by health ministry is basically well-structured. However, we expect this committee would possibly reduce the chance of the act of scientific misconducts. Though, I do not believe that current designed structure can be resulted in preventing the act of ethical misbehavior. From scientific point of view, it is long that everyone acknowledged that the scientific journals retract papers due to the various types of flaws include falsification, duplication, data manipulation and fabrication. The journal publishes a notice indicating a report of retraction, but it clearly sends a message that editors/reviewers (as a main scientific judge) are not efficiently involved in the review process [3, 4]. This is a neglected part of scientific publishing which always is far from the intense attention. Given new structure of ethical organization as termed ‘’ National Organization of Ethics in Research ‘’, training the editors and reviewers should be in the first priority. To now, researchers never got the credit or scores for their reviewing activities. Being ranked in the top list of the best accredited reviewers is a suggestion for science stakeholders to choose the best reviewers for national journals at least being a permanent member of editorial board. With this regard, Publons suggests the potential candidates to the senior editors in order to primary check the reviewers to be a member of editorial boards or blind reviewer process [5, 6]. The dark side of ethical issue is that we may not face with a real scientific researcher who commit such submissions or actually fraud! Indeed, it can raise another message that no specific education had been obliged for young researchers before they achieve the further promotions. Altogether, it can be concluded that asking independent advisors in design and develop this structure ‘’ National Organization of Ethics in Research ‘’ (NOER)is the most crucial step to have a new organization with scientific structure arranging and directing the such educations and ethical surveys for even senior professors in the national scale. Given the independency of NOER and independent advisors with proper background can help both ii) Ministry of Science, Research, and Technology to effectively prevent such bad news published in Nature and Scienc
最近,Abbasiyan等人。发表了一篇有趣的论文,题为“伊朗医学期刊的主编对抄袭有良好的认识、态度和做法吗?”,解决了近年来在伊朗研究氛围中发生的伦理争议[1]。在这项研究中,作者很好地讨论了最近的报告,并为伊朗的研究决策者提出了一个关键建议。Enjoo发表了一封信,表明迫切需要有一个新的组织有更好的情况[2]。与此同时,我认为在这一理念得到广泛推广之前,新的政策会对其有所帮助。乍一看,人们一致认为,目前卫生部实施的伦理行政结构基本上是结构良好的。然而,我们期望这个委员会可能会减少科学不端行为的机会。尽管如此,我不相信目前设计的结构可以防止不道德行为的行为。从科学的角度来看,很长一段时间以来,每个人都承认科学期刊撤回论文是由于各种类型的缺陷,包括伪造、复制、数据操纵和捏造。期刊发布了一份通知,指出了一份撤稿报告,但它清楚地传达了一个信息,即编辑/审稿人(作为主要的科学判断者)没有有效地参与审稿过程[3,4]。这是科学出版中一个被忽视的部分,总是远离高度关注。鉴于新的伦理组织结构被称为“国家研究伦理组织”,对编辑和审稿人的培训应放在首位。到目前为止,研究人员从来没有因为他们的评论活动而得到信用或分数。进入最佳审稿人名单是对科学利益相关者的建议,建议他们为国家期刊选择最好的审稿人,至少是编辑委员会的常任成员。在这方面,Publons向高级编辑推荐潜在的候选人,以便初步检查审稿人是否成为编委会成员或盲审过程[5,6]。伦理问题的阴暗面是,我们可能不会面对一个真正的科学研究人员,他提交了这样的论文,或者实际上是欺诈!事实上,它可以提出另一个信息,即年轻的研究人员在获得进一步的晋升之前没有义务接受特殊的教育。综上所述,请独立的顾问来设计和发展这种结构“国家研究伦理组织”(National Organization of Ethics in Research, NOER)是建立一个具有科学结构的新组织来安排和指导国家范围内甚至是高级教授的这种教育和伦理调查的最关键的一步。鉴于NOER的独立性和具有适当背景的独立顾问可以帮助科学研究和技术部有效防止此类坏消息发表在《自然》和《科学》上[7,8]。
{"title":"Letter to Editor: Requirement of National Organization of Ethics in Research","authors":"A. Abadi","doi":"10.22037/JPS.V9I4.23930","DOIUrl":"https://doi.org/10.22037/JPS.V9I4.23930","url":null,"abstract":"Recently, Abbasiyan et al . published an interesting paper entitled “Do the Editors-in-Chief of Iranian Medical Journals have a Good Knowledge, Attitude and Practice of Plagiarism?” , addressing the ethical disputes occurred in last years in the Iranian research atmosphere [1]. In this study, authors nicely discussed the recent reports and flagged a critical suggestion for research decision-makers in Iran. Enjoo published a letter indicating on urgent need to have a new organization for having better situation [2]. Meantime, I think that newer policy help this idea before it can be widely referred. At first glance, there is an agreement that the current ethical administrative structure conducted by health ministry is basically well-structured. However, we expect this committee would possibly reduce the chance of the act of scientific misconducts. Though, I do not believe that current designed structure can be resulted in preventing the act of ethical misbehavior. From scientific point of view, it is long that everyone acknowledged that the scientific journals retract papers due to the various types of flaws include falsification, duplication, data manipulation and fabrication. The journal publishes a notice indicating a report of retraction, but it clearly sends a message that editors/reviewers (as a main scientific judge) are not efficiently involved in the review process [3, 4]. This is a neglected part of scientific publishing which always is far from the intense attention. Given new structure of ethical organization as termed ‘’ National Organization of Ethics in Research ‘’, training the editors and reviewers should be in the first priority. To now, researchers never got the credit or scores for their reviewing activities. Being ranked in the top list of the best accredited reviewers is a suggestion for science stakeholders to choose the best reviewers for national journals at least being a permanent member of editorial board. With this regard, Publons suggests the potential candidates to the senior editors in order to primary check the reviewers to be a member of editorial boards or blind reviewer process [5, 6]. The dark side of ethical issue is that we may not face with a real scientific researcher who commit such submissions or actually fraud! Indeed, it can raise another message that no specific education had been obliged for young researchers before they achieve the further promotions. Altogether, it can be concluded that asking independent advisors in design and develop this structure ‘’ National Organization of Ethics in Research ‘’ (NOER)is the most crucial step to have a new organization with scientific structure arranging and directing the such educations and ethical surveys for even senior professors in the national scale. Given the independency of NOER and independent advisors with proper background can help both ii) Ministry of Science, Research, and Technology to effectively prevent such bad news published in Nature and Scienc","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"22 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82589937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-12DOI: 10.22037/JPS.V10I1.18370
Y. Mehrabi, M. Mahdavi, D. Khalili, A. Baghestani, Farideh Bagherzadeh-Khiabani
Introduction: The world prevalence of type 2 diabetes and its related increment mortality rate which needs high controls cost has attracted high scientific attention. Early detection of individuals who face this disease more than the others can prevent getting sick or at least reduce the disease consequences on public health. Regarding the costs and limitations of diagnostic tests, a statistical model is presented that helps predict the time of diabetes incidence and determines its risk factors. Furthermore, this model determines the significant predictor variables on response and considers them as model equation parameters. Materials and Methods : In this study, 803 pre-diabetic women in the age range of more than 20 years were selected from Tehran lipid and glucose study (TLGS) to examine the predictor variables on time of diabetes incidence. They were entered into the study in the phases 1 and 2 and were followed up to the phase 4. The predictor variables selection was performed using the Stepwise Model (SM) and the Bayesian Model Averaging (BMA). Then, the predictive discrimination was used to compare the results of both models. The Log-rank test was performed and the Kaplan-Meier Curve was plotted. The statistical analyses were performed using R software (version 3.1.3). Results : The Backward Stepwise Model (BSM), the Forward Stepwise Model (FSM) and the BMA have used 9, 10 and 6 variables, respectively. Although the BMA selected predictor variables number is much lower than the SM, the prediction ability remains nearly constant. Conclusions : The BMA has averaged on the supported models using dataset. This model has shown nearly constant accuracy despite the selection of lower predictor variables number in comparison to the SM.
{"title":"Superiority of Bayesian Model Averaging to Stepwise Model in Selection of Factors Related to the Incidence of Type II diabetes in Pre-diabetic Women","authors":"Y. Mehrabi, M. Mahdavi, D. Khalili, A. Baghestani, Farideh Bagherzadeh-Khiabani","doi":"10.22037/JPS.V10I1.18370","DOIUrl":"https://doi.org/10.22037/JPS.V10I1.18370","url":null,"abstract":"Introduction: The world prevalence of type 2 diabetes and its related increment mortality rate which needs high controls cost has attracted high scientific attention. Early detection of individuals who face this disease more than the others can prevent getting sick or at least reduce the disease consequences on public health. Regarding the costs and limitations of diagnostic tests, a statistical model is presented that helps predict the time of diabetes incidence and determines its risk factors. Furthermore, this model determines the significant predictor variables on response and considers them as model equation parameters. Materials and Methods : In this study, 803 pre-diabetic women in the age range of more than 20 years were selected from Tehran lipid and glucose study (TLGS) to examine the predictor variables on time of diabetes incidence. They were entered into the study in the phases 1 and 2 and were followed up to the phase 4. The predictor variables selection was performed using the Stepwise Model (SM) and the Bayesian Model Averaging (BMA). Then, the predictive discrimination was used to compare the results of both models. The Log-rank test was performed and the Kaplan-Meier Curve was plotted. The statistical analyses were performed using R software (version 3.1.3). Results : The Backward Stepwise Model (BSM), the Forward Stepwise Model (FSM) and the BMA have used 9, 10 and 6 variables, respectively. Although the BMA selected predictor variables number is much lower than the SM, the prediction ability remains nearly constant. Conclusions : The BMA has averaged on the supported models using dataset. This model has shown nearly constant accuracy despite the selection of lower predictor variables number in comparison to the SM.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"42 2 1","pages":"3-12"},"PeriodicalIF":0.0,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78340129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the last issue of the Journal of Paramedical Sciences, Abbasiyan, et al in their Original Article “Do the editors-in-chief of Iranian medical journals have a good knowledge, attitude and practice of plagiarism” showed that the knowledge, attitude, and the practice (KAP) of the chief editors of scholarly journals in Iranian Medical Universities located in the capital city is in high and favorable level (1.58 out of 2) [1]. I would like to discuss the probable false messages of such articles for science ethical managers in the country. For some years, every several-months or several-years a scholarly paper or news has been published to show the ethics situation of academic researches or publication ethics in Iran periodically [2-5]. Some Iranian scientists think these reports are unfair [6], and some non-Iranian reporters named it a scandal [7] ; and yet, facts demonstrate little improvements with regards to ethical situation compared with the past. I believe that accepting the already existing problems is the first step for resolving them. Although I agree with Ataie-Ashtiani [8] and others who think that some magnifications have been made on the special case of IR Iran, as Farrokhi stated, unfortunately there are some problems including the presence of misconduct and also unawareness about how to explain and excuse when a mistake is discovered [9]. As I mentioned before, although there are some defects in our laws regarding managing academic dishonesty [10], there are also other regulations and newly approved rules [11] for such issues. Such hopeful studies [1] and laws [11] shows some attainments, while I still think it is essential to create a national organization to evaluate and disclose all cases of scientific misconduct and frauds and declare their punishments publicly. If such an organization to monitor and evaluate the integrity of researches exists, it should have clear equitable strategy to approach similar cases with different scientific degrees or other types of official power or position. As stated previously, although there are some defects in our laws to manage academic dishonesty [10], there are also other regulations and newly approved rules [11] to accomplish.
在最近一期的Journal of parammedical Sciences中,Abbasiyan等人在其原创文章《伊朗医学期刊主编是否对抄袭有良好的认识、态度和实践》中显示,位于首都的伊朗医科大学学术期刊主编的知识、态度和实践(KAP)处于较高的有利水平(1.58 / 2)[1]。我想讨论这类文章可能给我国科学伦理管理人员带来的错误信息。几年来,每隔几个月或几年就会有一篇学术论文或新闻定期发表,展示伊朗学术研究或出版伦理的伦理状况[2-5]。一些伊朗科学家认为这些报道不公平[6],一些非伊朗记者称其为丑闻[7];然而,事实表明,与过去相比,道德状况几乎没有改善。我认为,接受已经存在的问题是解决问题的第一步。虽然我同意Ataie-Ashtiani[8]等人的观点,他们认为伊朗国际关系的特殊情况被夸大了,但正如Farrokhi所说,不幸的是,存在一些问题,包括存在不当行为,以及在发现错误时不知道如何解释和原谅[9]。正如我之前提到的,虽然我国在管理学术不诚实方面的法律存在一些缺陷[10],但也有其他的法规和新批准的规章[11]。这些充满希望的研究[1]和法律[11]显示了一些成就,但我仍然认为有必要建立一个全国性的组织来评估和披露所有的科学不端行为和欺诈案件,并公开宣布对它们的惩罚。如果存在这样一个监督和评估研究完整性的组织,它应该有明确的公平策略来处理不同科学学位或其他类型的官方权力或职位的类似案例。如前所述,虽然我国在管理学术不诚信方面的法律存在一些缺陷[10],但也有其他法规和新批准的规章[11]可以完成。
{"title":"Letter to Editor: Do Iranian Medical Journal Editors Have a Good Knowledge, Attitude and Practice of Plagiarism?","authors":"Seyed Ali Enjoo","doi":"10.22037/JPS.V9I4.22118","DOIUrl":"https://doi.org/10.22037/JPS.V9I4.22118","url":null,"abstract":"In the last issue of the Journal of Paramedical Sciences, Abbasiyan, et al in their Original Article “Do the editors-in-chief of Iranian medical journals have a good knowledge, attitude and practice of plagiarism” showed that the knowledge, attitude, and the practice (KAP) of the chief editors of scholarly journals in Iranian Medical Universities located in the capital city is in high and favorable level (1.58 out of 2) [1]. I would like to discuss the probable false messages of such articles for science ethical managers in the country. For some years, every several-months or several-years a scholarly paper or news has been published to show the ethics situation of academic researches or publication ethics in Iran periodically [2-5]. Some Iranian scientists think these reports are unfair [6], and some non-Iranian reporters named it a scandal [7] ; and yet, facts demonstrate little improvements with regards to ethical situation compared with the past. I believe that accepting the already existing problems is the first step for resolving them. Although I agree with Ataie-Ashtiani [8] and others who think that some magnifications have been made on the special case of IR Iran, as Farrokhi stated, unfortunately there are some problems including the presence of misconduct and also unawareness about how to explain and excuse when a mistake is discovered [9]. As I mentioned before, although there are some defects in our laws regarding managing academic dishonesty [10], there are also other regulations and newly approved rules [11] for such issues. Such hopeful studies [1] and laws [11] shows some attainments, while I still think it is essential to create a national organization to evaluate and disclose all cases of scientific misconduct and frauds and declare their punishments publicly. If such an organization to monitor and evaluate the integrity of researches exists, it should have clear equitable strategy to approach similar cases with different scientific degrees or other types of official power or position. As stated previously, although there are some defects in our laws to manage academic dishonesty [10], there are also other regulations and newly approved rules [11] to accomplish.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"31 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89292238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}