Studies on local anesthetics. XXV. (Physicochemical properties of drugs. V.)

Abstract

The authors have studied the anesthetic activity of thirty diethylaminoethyl esters of substituted carbamic acids by surface and infiltration techniques and have attempted to correlate this activity with certain physicochemical properties, namely: surface tension activity, adsorbability, liposolubility, ability to coagulate colloids, and basicity of these compounds. The results obtained have been evaluated tabularly, graphically, and statistically. At the same time a summary has been given of the earlier results and they have been included in the discussion.