A. P. Lemberger, T. Higuchi, L. W. Busse, D. Wurster
Abstract The influence of thermal aging at room and elevated temperatures on submicron cholesterol particles prepared by the freeze‐drying technique has been investigated. It is shown that the rate of decrease in the specific surface area as a result of thermal aging is dependent upon the aging temperature and adheres closely to the relationship described by the Arrhenius equation. The theoretical aspects of a possible mechanism operative in the reduction of the specific surface area are discussed.
{"title":"Influence of temperature on the rate of growth of microcrystalline cholesterol. II.","authors":"A. P. Lemberger, T. Higuchi, L. W. Busse, D. Wurster","doi":"10.1002/JPS.3030430607","DOIUrl":"https://doi.org/10.1002/JPS.3030430607","url":null,"abstract":"Abstract The influence of thermal aging at room and elevated temperatures on submicron cholesterol particles prepared by the freeze‐drying technique has been investigated. It is shown that the rate of decrease in the specific surface area as a result of thermal aging is dependent upon the aging temperature and adheres closely to the relationship described by the Arrhenius equation. The theoretical aspects of a possible mechanism operative in the reduction of the specific surface area are discussed.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88244903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A note on the crystallography of alstonidine.","authors":"A. Van Camp, H. A. Rose","doi":"10.1002/JPS.3030460816","DOIUrl":"https://doi.org/10.1002/JPS.3030460816","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83019069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alstonia alkaloids. VII. The structure of alstonidine.","authors":"Harold Boaz, R. C. Elderfield, Erhard Schenker","doi":"10.1002/JPS.3030460817","DOIUrl":"https://doi.org/10.1002/JPS.3030460817","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73748653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. A. Lawrence, C. M. Carpenter, A. W. NAYLOR-FOOTE
Comparative tests were made of the bactericidal and fungicidal activities of an iodophor (Wescodyne®), Roccal®, Amphyl®, and phenol. Roccal was the only germicide in the group that was adversely affected by a synthetic hard water solution. With the exception of phenol, the remaining germicides showed some loss in bactericidal activity when examined in the presence of serum. Wescodyne was found to be highly fungicidal and distinctly lethal for tubercle bacilli. The same compound was also effective in moderate concentrations against spores of B. subtilis
{"title":"Iodophors as disinfectants.","authors":"C. A. Lawrence, C. M. Carpenter, A. W. NAYLOR-FOOTE","doi":"10.1002/JPS.3030460813","DOIUrl":"https://doi.org/10.1002/JPS.3030460813","url":null,"abstract":"Comparative tests were made of the bactericidal and fungicidal activities of an iodophor (Wescodyne®), Roccal®, Amphyl®, and phenol. Roccal was the only germicide in the group that was adversely affected by a synthetic hard water solution. With the exception of phenol, the remaining germicides showed some loss in bactericidal activity when examined in the presence of serum. Wescodyne was found to be highly fungicidal and distinctly lethal for tubercle bacilli. The same compound was also effective in moderate concentrations against spores of B. subtilis","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80476398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The roots and vines of Cissampelos pareira Linn. from Madras yielded l -curine, d -iso-chondrodendrine, and hayatin. Preliminary pharmacological study of the methanol-extractable alkaloids, of the methiodide prepared from the latter mixture, and of the quaternary alkaloids, showed that all had curare-like activity. The relationship of the composition and pharmacological activity of the alkaloidal mixture to the problem of the botanical source of the drug radix pareirae bravae is discussed.
西葫芦的根和藤蔓。从马德拉斯提取了l -curine, d -异软骨鞘碱和hayatin。对甲醇萃取生物碱、后一混合物制得的甲氧化物和四元生物碱的初步药理学研究表明，它们都具有类似弧度的活性。讨论了生物碱合剂的组成和药理活性与药物的植物来源问题的关系。
{"title":"Menispermaceae alkaloids. I. The alkaloids of Cissampelos pareira Linn. and the origin of radix pareirae brave.","authors":"S. M. Kupchan, N. Yokoyama, J. Beal","doi":"10.1002/JPS.3030491112","DOIUrl":"https://doi.org/10.1002/JPS.3030491112","url":null,"abstract":"The roots and vines of Cissampelos pareira Linn. from Madras yielded l -curine, d -iso-chondrodendrine, and hayatin. Preliminary pharmacological study of the methanol-extractable alkaloids, of the methiodide prepared from the latter mixture, and of the quaternary alkaloids, showed that all had curare-like activity. The relationship of the composition and pharmacological activity of the alkaloidal mixture to the problem of the botanical source of the drug radix pareirae bravae is discussed.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81572045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Menispermaceae alkaloids. I. The alkaloids of Cissampelos pareira Linn. and the origin of radix pareirae brave.","authors":"S M KUPCHAN, N YOKOYAMA, J L BEAL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23421727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ratbioassay of combinations of diuretics.","authors":"M D ACETO, C T ICHNIOWSKI","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23966245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infrared analysis of pharmaceuticals. 1. Application of the potassium bromide disk technique to some steroids, alkaloids, barbiturates, and other drugs.","authors":"A L HAYDEN, O R SAMMUL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23443694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and metabolic studies of C14-labeled hemicholinium Number three.","authors":"F R DOMER, F W SCHUELER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23439988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The quantitative potassium bromide disk technique has been investigated and methods have been adopted for its application to some pharmaceuticals. Average deviations from linearity within ±4.0 per cent were obtained with some crystalline compounds. Analyses of pharmaceutical preparations, by hand-grinding or vibrator-grinding methods, resulted in average agreement within ±3 to ±4.5 per cent with ultraviolet spectrophotometric or gravimetric determinations.
{"title":"Infrared analysis of pharmaceuticals. 1. Application of the potassium bromide disk technique to some steroids, alkaloids, barbiturates, and other drugs.","authors":"A. L. Hayden, O. R. Sammul","doi":"10.1002/JPS.3030490802","DOIUrl":"https://doi.org/10.1002/JPS.3030490802","url":null,"abstract":"The quantitative potassium bromide disk technique has been investigated and methods have been adopted for its application to some pharmaceuticals. Average deviations from linearity within ±4.0 per cent were obtained with some crystalline compounds. Analyses of pharmaceutical preparations, by hand-grinding or vibrator-grinding methods, resulted in average agreement within ±3 to ±4.5 per cent with ultraviolet spectrophotometric or gravimetric determinations.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79769676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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