Novel Resonance-Like Impedance Spectroscopy for Life Science Applications

Giancarlo Ayala-Charca, S. Magierowski, E. Ghafar-Zadeh
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引用次数: 1

Abstract

This paper presents a novel real-time resonance-like impedance spectroscopy method using ITO electrodes. These electrodes can exhibit N-Shape Nonlinear Negative Differential Resistance (NDR) under specific conditions. In these conditions, the impedance of the electrode becomes pure capacitive, resulting in a resonance-shape spectrum. The resonance frequency is related to electrochemical changes at the interface between electrode and sample. We validated this method using microfabricated ITO electrodes exposed to two chemical solutions, including DMEM culture medium and 0.9% NaCl Solution. Based on these results, the proposed method can offer great advantages of rapid impedance spectroscopy for high throughput screening of chemical and biological materials suitable for a variety of life sciences applications.
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生命科学应用的新型类共振阻抗谱
本文提出了一种利用ITO电极的实时类共振阻抗谱方法。这些电极在特定条件下可以表现出n形非线性负差分电阻(NDR)。在这些条件下,电极的阻抗变成纯电容性,导致共振形状的频谱。谐振频率与电极与样品界面处的电化学变化有关。我们将微型ITO电极暴露在两种化学溶液中,包括DMEM培养基和0.9% NaCl溶液中,验证了该方法。基于这些结果,该方法具有快速阻抗谱高通量筛选适合多种生命科学应用的化学和生物材料的巨大优势。
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