Biosynthesis of Iron Oxide Nanoparticles using Aqueous Extract of Convolvulus Pluricaulis Plant, its Characterization and Acute Oral Toxicity Studies

Abstract

The synthesis of nanoparticles by green approach has been of great interest because of its ecofriendly and non-toxic potential in biomedical applications. The present study was aimed to synthesize Convolvulus pluricaulis iron oxide nanoparticles (CPIO) using its aqueous extract. The phytochemicals available in the aqueous extract acted as effective reducing agent and capping agent. The CPIO nanoparticles synthesized were characterized by PSA, XRD, FTIR, SEM and TEM. FTIR measurements showed the CPIO nanoparticles having a coating of phytochemical compounds indicating a possible role of biomolecules from Convolvulus pluricaulis for capping and efficient stabilization of the CPIO nanoparticles. The XRD spectrum confirmed the crystalline structure of CPIO nanoparticles with an average particle size of 32.8nm .The synthesized CPIO nanoparticles are found to be agglomerated porous nanoparticles from the SEM and TEM images. Acute oral toxicity studies were carried out for a period of 14 days and no mortality was observed during this treatment period. As no synthetic reagents were used in this method, the synthesized CPIO nanoparticles are non-toxic, biocompatible so have potential biomedical applications.