Research Progress on Angiogenesis Imbalance and Pathogenesis of Preeclampsia and Predictive Treatment

Abstract

Preeclampsia, one of the unique diseases of pregnancy, is a systemic vascular disease induced by various factors. Its main feature is that new-onset hypertension and proteinuria will appear after 20 weeks of pregnancy. Preeclampsia is the main cause of morbidity and mortality in pregnant women and perinatal babies. Many clinical and experimental studies have shownthat the pathological basis of preeclampsia is maternal endothelial dysfunction caused by placental factors. Moreover, it has been determined that the increase in placental anti-angiogenic factors is the main cause of vascular endothelial dysfunction and systemic vascular dysfunction in pregnant women. This review summarizes the latest advancesin the molecular mechanisms of endothelial dysfunction caused by placental anti-angiogenic factors and new clinical strategies based on these findings.