Impact of Antioxidant-rich Diet on Decreasing Oxidized Low-density Lipoproteins, 8-hydroxy-2´-deoxyguanosine and HbA1c in Saudi Men

Abstract

Objectives: Oxidative stress is a major cause of many disorders. However, the benefits of antioxidant-rich diet on the situation of oxidative stress and overall health remains under continuous investigations. Saudi Dietary Guidelines (The Healthy Food Palm) recommend the highest servings of fruits and vegetables for the middle-aged Saudi men (19-50 Years). We investigated the association between antioxidant-rich diet and levels of oxidized low-density lipoprotein, 8-OH-dG, lipid profile and HbA1c in Saudi men. Method: One hundred and fourteen healthy Saudi men were enrolled. The study group was categorized into Normal diet and Antioxidant-rich diet groups. Oxidized LDL, 8-OH dG, Lipid profile, and HbA1c were measured, and statistical methods were used for correlations and comparison between the two groups. Results: Decreased levels of 8-OH-dG was observed in the antioxidant rich diet group compared to the other group; p= 0.001. Similarly, the levels of Ox-LDL were lower in the antioxidant rich diet group compared to normal group; p=0.004. Total cholesterol, Triglycerides, and LDL were found to be significantly elevated in normal group compared to antioxidant rich diet group; p>0.001. HbA1c was higher in the normal group; p>0.001. Conclusion: In conclusion, the present study suggests that antioxidant rich diet may have a positive impact on decreasing oxidized low-density lipoproteins and 8-OH-dG. Additionally, using an antioxidant rich diet may enhance the lipid profile and decrease HbA1c. Larger studies to validate these findings and explore the benefits of healthy diet are recommended.