Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy Under Synchrotorn Radiation

Abstract

Olympiadane nanomolecules are a mechanically-interlocked molecule composed of five interlocking macrocycles that resembles the olympic rings. The nanomolecule is a linear pentacatenane or a catenane [1,2]. It was synthesized and named by Fraser Stoddart and co-workers in 1994 [1,2]. The molecule was designed without any practical use in mind, although other catenanes may have possible application to the construction of a molecular computer in Nano scale (Figures 1 and 2) [1,2]. Furthermore, Olympiadane nanomolecules are an important class of ring fused heterocyclic Nano compounds exhibit a wide spectrum of biological, medical, medicinal, pharmaceutical, chemical and clinical activities as agent for cancer enzymotherapy, immunotherapy, chemotherapy, radiotherapy, hormone therapy and targeted therapy under synchrotorn radiation [3–34]. Therefore, development of new and efficient synthetic method for the preparation of these Nano compounds is of importance in both synthetic organic chemistry and also medicinal and pharmaceutical chemistry. The classical synthesis, pharmacokinetics, pharmacodynamics, dosing, stability, safety and efficacy of Olympiadane nanomolecules mainly involve the use of acylchlordie and 2–pyridylalkylamine, followed by subsequent functionalization to anchor various electrophilic reagents. Other approaches include the use of imine derivatives, 2– cyanopyridine, and recently, benzotriazoles. During the course of our studies towards the development of new routes to the synthesis, pharmacokinetics, pharmacodynamics, dosing, stability, safety and efficacy of fused Nitrogen heterocyclic Nano compounds, we wish to introduce a valid and an efficient procedure for the synthesis, pharmacokinetics, pharmacodynamics, dosing, stability, safety and efficacy of Olympiadane nanomolecules via one–pot condensation of pyridyl ketone with aldehyde and NH4OAc in the presence of Lithium Chloride as an inexpensive neutral Lewis acid using microwave irradiation.