Anti-cancer properties of Microalgae (T1) Extract in Breast Cancer Cell Lines

Noor Al-Atieh, Salma E. Ahmad, Hanan Nazar, A. Ouhtit
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Abstract

Breast cancer (BC), a worldwide health issue, is the most common malignant cancer in women in Gulf region, including the State of Qatar. Unfortunately, malignant tumors has the capability to metastasis, which involves both migration and invasion of cancer cells which are the most threatening aspects of cancer (McSherry et al., 2007). Consequently, researchers have concentrated on Complementary and Alternative medicine (CAM) modalities, as conventional medicine has been facing various challenges such as; poor understanding of the mechanisms with BC proliferation and invasion within various groups of patients, drug resistance, and the failure of current therapies to completely cure the disease. A significant CAM method have been raised which is the treatment with herbs and extracts derived from seeds, leaves, fruits and roots of plants; each of these invariably represents a combination of several bioactive compounds. Our biofuel has provided us with a crude extract of a microalgae coded as T1 that consist of carotenoids, chlorophyll a, and chlorophyll b. Carotenoids is a bioactive molecule that inhibits the proliferation, migration, invasion and induce apoptosis to tumor cells.
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微藻(T1)提取物对乳腺癌细胞株的抗癌作用
乳腺癌是一个全球性的健康问题,是海湾地区(包括卡塔尔国)妇女最常见的恶性癌症。不幸的是,恶性肿瘤具有转移能力,包括癌细胞的迁移和侵袭,这是癌症最具威胁性的方面(McSherry et al., 2007)。因此,研究人员将重点放在补充和替代医学(CAM)模式上,因为传统医学面临着各种挑战,例如;对不同患者群体中BC增殖和侵袭的机制了解不足,耐药,以及目前治疗方法无法完全治愈该疾病。提出了一种重要的CAM方法,即用植物种子、叶、果和根提取的草药和提取物进行处理;每一种都是几种生物活性化合物的组合。我们的生物燃料为我们提供了一种编码为T1的微藻的粗提取物,它由类胡萝卜素、叶绿素a和叶绿素b组成。类胡萝卜素是一种生物活性分子,可以抑制肿瘤细胞的增殖、迁移、侵袭和诱导凋亡。
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