RNA as a Drug Target and its Tools and Databases

Nikita Chordia, Anil Kumar
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Abstract

Earlier, during 19th century, there was a concept that RNA is a passive carrier of genetic information. However, with advancement, now it is well established that RNA performs a number of vital roles in the cell, and its malfunction may lead to a disease. The recent advancement in the knowledge about diversity, structural and functional information related to RNAs has put them in the lime light as a drug target. Here, in this mini-review, discussion has been done that coding as well as non-coding RNA regions have potential as a drug target. Besides, a few databases and tools used for the RNA target prediction have also been discussed.
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RNA作为药物靶标及其工具和数据库
早在19世纪,就有一种观点认为RNA是遗传信息的被动载体。然而,随着研究的进展,现在已经确定RNA在细胞中起着许多至关重要的作用,它的功能障碍可能导致疾病。近年来,有关rna的多样性、结构和功能信息方面的知识的进步,使它们作为一种药物靶点受到关注。在这篇综述中,我们讨论了编码和非编码RNA区域作为药物靶点的潜力。此外,还讨论了一些用于RNA靶标预测的数据库和工具。
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