Association of deletion polymorphisms of GSTM1 and GSTT1 genes with the degree of lung damage in elderly people after COVID-19

IF 0.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Yakut Medical Journal Pub Date : 2023-01-01 DOI:10.25789/ymj.2023.81.18
V. Nikolaev, E. Rumyantsev, S. Sofronova, S. Efremova, A. Romanova
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Abstract

To analyze the association of polymorphisms of the GSTM1 and GSTT1 genes with the degree of lung damage in elderly people in Yakutia who suffered from COVID-19, a survey of volunteers who had a coronavirus infection aged 60 to 75 years (average age 64.470 +/- 0.602 years) was conducted. The results of our study find out that the combination of zero deletion genotypes GSTM1 and GSTT1 is a risk factor for the development of severe lung lesions in the elderly.
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GSTM1和GSTT1基因缺失多态性与新冠肺炎后老年人肺损伤程度的关系
为了分析GSTM1和GSTT1基因多态性与雅库特老年人COVID-19肺损伤程度的关系,对60 ~ 75岁(平均年龄64.470 +/- 0.602岁)的冠状病毒感染志愿者进行了调查。我们的研究结果发现零缺失基因型GSTM1和GSTT1的组合是老年人发生严重肺部病变的危险因素。
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Yakut Medical Journal
Yakut Medical Journal MEDICINE, RESEARCH & EXPERIMENTAL-
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