Exploration of treatments for subarachnoid hemorrhage

M. R. Hosseini Siyanaki, B. Lucke-Wold, Majid Khan
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引用次数: 1

Abstract

Subarachnoid hemorrhage (SAH) continues to be a leading cause of morbidity and mortality, with cerebral vasospasm as a common etiology of worse clinical progression. The purpose of this study was to evaluate and review the current literature concerning the effective treatment of SAH. The treatment options for SAH are expanding as new therapeutic targets are identified. Nimodipine is the primary medication prescribed due to its neuroprotective properties. In addition, certain drugs can enhance lymphatic flow and influence the recovery process, such as Dexmedetomidine, SSRIs, and DL-3-n-butylphthalide. Vasospastic and ischemic patients commonly undergo transluminal balloon angioplasty. Clinical trials have not yet provided conclusive evidence to support the use of magnesium or statins. Moreover, other agents such as calcium channel blockers, milrinone, hydrogen sulfide, exosomes, erythropoietin, cilostazol, fasudil, albumin, Eicosapentaenoic acid, corticosteroids, minocycline, and stellate ganglion blockade should be investigated further.
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蛛网膜下腔出血的治疗探讨
蛛网膜下腔出血(SAH)仍然是发病率和死亡率的主要原因,脑血管痉挛是临床恶化的常见病因。本研究的目的是评估和回顾目前关于SAH有效治疗的文献。随着新的治疗靶点的确定,SAH的治疗选择正在扩大。尼莫地平是由于其神经保护特性而开的主要药物。此外,某些药物可以增强淋巴流动,影响恢复过程,如右美托咪定、SSRIs、dl -3-n-丁苯酞。血管痉挛和缺血性患者通常接受腔内球囊血管成形术。临床试验尚未提供确凿的证据来支持镁或他汀类药物的使用。此外,其他药物如钙通道阻滞剂、米立酮、硫化氢、外泌体、促红细胞生成素、西洛他唑、法舒地尔、白蛋白、二十碳五烯酸、皮质类固醇、米诺环素和星状神经节阻断剂等也应进一步研究。
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