E. Kryukova, A. S. Potapenko, T. Andreeva, I. Ivanov, V. V. Ryabinin, R. Ziganshin, V. Starkov, N. Ayvazyan, V. Tsetlin, Y. Utkin
{"title":"Dimeric disintegrins from the Vipera ursinii steppe viper venom","authors":"E. Kryukova, A. S. Potapenko, T. Andreeva, I. Ivanov, V. V. Ryabinin, R. Ziganshin, V. Starkov, N. Ayvazyan, V. Tsetlin, Y. Utkin","doi":"10.31857/s0869-56524885567-570","DOIUrl":null,"url":null,"abstract":"Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the V1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":"38 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Доклады Академии наук","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31857/s0869-56524885567-570","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the V1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa.
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