Biochemical and Serological Tests for People Recovering from COVID-19

Enass Waad Al-Hadidi, Mahmoud Abduljabbar Al-Tobji
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Abstract

Aims: The purpose of this study was to detect some biological and serological factors in COVID-19 recovery patients, as well as their relationships with antibody levels 8 months after infection. Materials and Methods: 92 blood samples were obtained; 67 of them had COVID-19 infections 4 months prior, and 25 blood samples served as control samples. The participants' ages ranged from 17-75 year. Determination levels of immunoglobulin IgG and IgM antibodies was carried out on (188) samples of infection over for ages ranging from 15-75 years by using enzyme linked immunosorbant assay  (ELISA). Results: The people under research have 94.03% IgG and 55.22% IgM. Furthermore, the maximum concentration of IgG was seen after 6 months of infection. Aberrant lactate dehydrogenase (LDH) levels were found in 20 people at 41.6% after 4 months, in 25 people at 52.08% after 6 months, and in 8 people at 8.33% after 8 months. In contrast, aberrant C- reactive protein (CRP) levels were found in 10.4% of the participants after 4 to 8 months of infection and 12.5% after 6 months, with no significant association between them. Conclusion: The maximum IgG level was reported 6 months after infection, and the LDH and CRP tests were abnormal 6 months later. On the other hand, 4 months after the infection, both urea and creatinine levels were abnormal, as was the IgG concentration.
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COVID-19恢复者的生化和血清学检测
目的:本研究的目的是检测COVID-19康复患者的一些生物学和血清学因素,以及它们与感染后8个月抗体水平的关系。材料与方法:采集92份血样;其中67人在4个月前感染COVID-19, 25份血样作为对照样本。参与者的年龄在17-75岁之间。采用酶联免疫吸附试验(ELISA)对188例年龄在15 ~ 75岁的患者进行了免疫球蛋白IgG和IgM抗体的检测。结果:研究对象IgG阳性率为94.03%,IgM阳性率为55.22%。IgG在感染后6个月达到最高值。乳酸脱氢酶(LDH)异常20例,4个月后为41.6%;25例,6个月后为52.08%;8例,8个月后为8.33%。相比之下,10.4%的参与者在感染4至8个月后发现异常的C反应蛋白(CRP)水平,12.5%的参与者在感染6个月后发现异常,两者之间没有显著关联。结论:IgG在感染后6个月达到最高值,LDH和CRP在感染后6个月出现异常。另一方面,感染后4个月,尿素和肌酐水平异常,IgG浓度异常。
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