Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions

Pascal Gisenya, Bati Daddy, P. Lutgen
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引用次数: 4

Abstract

Objective: The objective is to study in vivo the effect of the administration of Artemisia infusions as supplement in combination with the prescribed WHO treatment. Promising in vitro results needed to be confirmed in vivo before proceeding to larger scale clinical trials. Methods: A first pilot study was run with 5 patients using Artemisia afra infusions and a second one on 10 patients with Artemisia annua infusions. Over 15 days their fever, diurnal and nocturnal coughing, asthenia, Ziehl-Neelsen assay were monitored. Results: Artemisia afra infusions give faster symptoms resolution and healing. After 5 days all TB symptoms had disappeared whilst for Artemisia annua it took 10 days. The Ziehl-Neelsen assay was negative after 10 days for the Artemisia afra treatment and after 15 days for Artemisia annua. Conclusion: These observations on the administration of Artemisia infusions in combination with the conventional WHO treatment gave an astonishingly faster relief of the symptoms than conventional treatment alone. This could be a base to provide a potential natural and inexpensive therapy for TB treatment failure and resistance. More in vivo studies with a larger cohort are required to confirm our findings.
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结核病防治突破:青蒿注射液疗效高
目的:目的是研究青蒿注射液与WHO规定的治疗方法联合使用的体内效果。在进行更大规模的临床试验之前,有希望的体外结果需要在体内得到证实。方法:第一项中试研究采用青蒿注射液5例,第二项中试研究采用黄花蒿注射液10例。在15天内监测患者发热、昼夜咳嗽、虚弱、Ziehl-Neelsen测定。结果:黄花蒿注射液能加快症状缓解和愈合。5天后,所有结核症状消失,而青蒿则需要10天。青蒿治疗10天后Ziehl-Neelsen试验为阴性,青蒿治疗15天后Ziehl-Neelsen试验为阴性。结论:这些观察结果表明,青蒿注射液与世卫组织常规治疗相结合,比单独使用常规治疗更快地缓解了症状。这可能是为结核病治疗失败和耐药性提供一种潜在的自然和廉价疗法的基础。需要更多的体内研究和更大的队列来证实我们的发现。
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